SUMMARY OF KEY OUTCOMES

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OnabotulinumtoxinA for Injection (Botox): For the Prophylaxis of Headaches in Adults With Chronic Migraine (≥ 15 Days per Month With Headache Lasting 4 Hours a Day or Longer) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jul.

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OnabotulinumtoxinA for Injection (Botox): For the Prophylaxis of Headaches in Adults With Chronic Migraine (≥ 15 Days per Month With Headache Lasting 4 Hours a Day or Longer) [Internet].

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APPENDIX 2SUMMARY OF KEY OUTCOMES

Table 16When Considering Only Costs, Outcomes, and Quality of Life, How Attractive is OnabotulinumtoxinA Relative to Best Supportive Care?

Ona A Versus BSC	Attractive	Slightly Attractive	Slightly Unattractive	Unattractive
Costs (total)			X
Drug treatment costs alone				X
Clinical Outcomes		X
Quality of Life		X
Incremental CE Ratio or Net Benefit Calculation	$25,470 per QALY (restricted population) $28,940 per QALY (full population)

: BSC = best supportive care; CE = cost-effectiveness; NA = not applicable; Ona A = onabotulinumtoxinA.
: Note: Table 16 is based on both results from the manufacturer.

CADTH Common Drug Review (CDR) reanalyses could not provide an accurate estimate of the incremental cost-utility ratio (ICUR), given the issues around the model assumptions and uncertainties in the clinical data.

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OnabotulinumtoxinA for Injection (Botox): For the Prophylaxis of Headaches in Adults With Chronic Migraine (≥ 15 Days per Month With Headache Lasting 4 Hours a Day or Longer) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jul. APPENDIX 2, SUMMARY OF KEY OUTCOMES.