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OnabotulinumtoxinA for Injection (Botox): For the Prophylaxis of Headaches in Adults With Chronic Migraine (≥ 15 Days per Month With Headache Lasting 4 Hours a Day or Longer) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jul.

Cover of OnabotulinumtoxinA for Injection (Botox)

OnabotulinumtoxinA for Injection (Botox): For the Prophylaxis of Headaches in Adults With Chronic Migraine (≥ 15 Days per Month With Headache Lasting 4 Hours a Day or Longer) [Internet].

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APPENDIX 2LITERATURE SEARCH STRATEGY

OVERVIEW
Interface:Ovid
Databases:Embase 1974 to present
MEDLINE Daily and MEDLINE 1946 to present
MEDLINE In-Process & Other Non-Indexed Citations
Note: Subject headings have been customized for each database. Duplicates between databases were removed in Ovid.
Date of Search:October 16, 2013
Alerts:Weekly search updates until (date of CDEC meeting)
Study Types:randomized controlled trials
Limits:No date or language limits were used
Human filter was applied
Conference abstracts were excluded
SYNTAX GUIDE
/At the end of a phrase, searches the phrase as a subject heading
.shAt the end of a phrase, searches the phrase as a subject heading
MeSHMedical Subject Heading
expExplode a subject heading
*Before a word, indicates that the marked subject heading is a primary topic;
or, after a word, a truncation symbol (wildcard) to retrieve plurals or varying endings
adjRequires words are adjacent to each other (in any order)
adj#Adjacency within # number of words (in any order)
.tiTitle
.abAbstract
.otOriginal title
.hwHeading word; usually includes subject headings and controlled vocabulary
.ptPublication type
.rnCAS registry number
.nmName of substance word
pmezOvid database code; MEDLINE In-Process & Other Non-Indexed Citations, MEDLINE Daily and Ovid MEDLINE 1946 to Present
oemezdOvid database code; Embase 1974 to present, updated daily
MULTI-DATABASE STRATEGY
Line #Strategy
1exp Botulinum Toxin Type A/ or (botulinum* or botox or dysport* or oculinum or BTX-A or BTX or BTXA or BoNTA* or Botulin A or Botulin toxin A or Neuronox or Onaclostox or Xeomin or nabotulinumtoxinA or onabotulinum*).ti,ab,ot,sh,hw,rn,nm.
2(93384-43-1 or EC 3-4-24-69).rn,nm.
31 or 2
4exp Migraine Disorders/
5(migraine or migraines or migrainous or (sick adj headach*) or migrainosus or migraineur* or antimigrain* or migraigne).ti,ab.
64 or 5
73 and 6
87 use pmez
9exp *botulinum toxin A/ or (botulinum* or botox or dysport* or oculinum or BTX-A or BTX or BTXA or BoNTA* or Botulin A or Botulin toxin A or Neuronox or Onaclostox or Xeomin or nabotulinumtoxinA or onabotulinum*).ti,ab.
10(migraine or migraines or migrainous or (sick adj headach*) or migrainosus or migraineur* or antimigrain* or migraigne).ti,ab.
11exp migraine/
1210 or 11
139 and 12
1413 use oemezd
158 or 14
16conference abstract.pt.
1715 not 16
188 or 17
19remove duplicates from 18
20exp animals/
21exp animal experimentation/ or exp animal experiment/
22exp models animal/
23nonhuman/
24exp vertebrate/ or exp vertebrates/
25animal.po.
26or/20-25
27exp humans/
28exp human experimentation/ or exp human experiment/
29human.po.
30or/27-29
3126 not 30
3219 not 31
33(Randomized Controlled Trial or Controlled Clinical Trial).pt.
34Randomized Controlled Trial/
35Randomized Controlled Trials as Topic/
36"Randomized Controlled Trial (topic)"/
37Controlled Clinical Trial/
38Controlled Clinical Trials as Topic/
39"Controlled Clinical Trial (topic)"/
40Randomization/
41Random Allocation/
42Double-Blind Method/
43Double-Blind Procedure/
44Double-Blind Studies/
45Single-Blind Method/
46Single Blind Procedure/
47Single-Blind Studies/
48Placebos/
49Placebo/
50Control Groups/
51Control Group/
52(random* or sham or placebo*).ti,ab,hw.
53((singl* or doubl*) adj (blind* or dumm* or mask*)).ti,ab,hw.
54((tripl* or trebl*) adj (blind* or dumm* or mask*)).ti,ab,hw.
55(control* adj3 (study or studies or trial*)).ti,ab.
56(Nonrandom* or non random* or non-random* or quasi-random* or quasirandom*).ti,ab,hw.
57allocated.ti,ab,hw.
58((open label or open-label) adj5 (study or studies or trial*)).ti,ab,hw.
59or/33-58
6032 and 59
OTHER DATABASES
PubMedSame MeSH, keywords, limits, and study types used as per MEDLINE search, with appropriate syntax used.
Trial registries (Clinicaltrials​.gov and others)Same keywords, limits used as per MEDLINE search.

Grey Literature

Dates for Search:To September 27, 2013
Keywords:Botox, onabotulinumtoxinA, onabotulinumtoxin A, botulinum toxin A, botulinum toxin type A, migraine, headache
Limits:No date or language limits used

Relevant websites from the following sections of the CADTH grey literature checklist, “Grey matters: a practical tool for evidence-based searching” (http://www.cadth.ca/en/resources/finding-evidence-is/grey-matters), were searched:

  • Health Technology Assessment Agencies
  • Health Economics
  • Clinical Practice Guidelines
  • Drug and Device Regulatory Approvals
  • Advisories and Warnings
  • Drug Class Reviews
  • Databases (free)
  • Internet Search

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Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

Bookshelf ID: NBK344297

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