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Ho C, Spry C. Central Venous Access Devices (CVADs) and Peripherally Inserted Central Catheters (PICCs) for Adult and Pediatric Patients: A Review of Clinical Effectiveness and Safety [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Apr 27.

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Central Venous Access Devices (CVADs) and Peripherally Inserted Central Catheters (PICCs) for Adult and Pediatric Patients: A Review of Clinical Effectiveness and Safety [Internet].

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Appendix 2Characteristics of Included Publications

Table A1Characteristics of Included Clinical Study

First Author, Year, CountryStudy Design Study ObjectivesInterventions/ComparatorsPatientsMain Outcomes
Pittiruti,7 2014, ItalyRCT
“Few randomized studies have investigated the impact of valved and non-valved power-injectable peripherally inserted central catheters (PICCs) in terms of incidence of occlusion, infection, malfunction and venous thrombosis” (p 519)		PICCs with Solo-2 proximal valve (Bard)
PICCs with PASV (Pressure Activated Safety Valve) proximal valve (Navilyst)
Non-valved PICCs (Medcomp)		188 patients. Mean PICC days were 56, 64 and 65 for the Solo valve group, PASV group and the no valve group, respectively
“We enrolled exclusively adult oncologic patients candidate to the insertion of a 4Fr single-lumen PICC for intermittent infusion of chemotherapy drugs for a period not exceeding 4 months” (p 520)		Primary outcomes: Incidence of occlusion and malfunction of the catheters
Secondary outcomes: PICC-related blood stream infection
Complications (obstruction, rupture)

PICCs = peripherally inserted central catheters; RCT = randomized controlled trial

Table A2Characteristics of Included Systematic Review

First Author, Year, CountryObjectives Literature Search StrategyInclusion CriteriaExclusion CriteriaNumber of studies included Main Outcomes
Zhong,8 2017, China“The aim of this systematic review and meta-analysis was to assess the efficacy of NS versus HS in the maintenance of the patency of CVCs in adult patients” (p 1)
“We systematically searched PubMed, Embase and the Cochrane library databases from the inception to 28 September 2016, using the following terms: “Sodium Chloride”, “Saline Solution, Hypertonic”, “NaCl”, “Heparin”, “Catheterization, Central Venous”, “Randomized Controlled Trial”, etc. (Additional file 3). There was no restriction on language” (p 2)		“Only clinical randomized controlled trials (RCTs) of NS flushing vs flushing with HS solution in adults were included” (p 2)“Exclusion criteria were (1) age <18 years, and (2) case reports, letters, reviews, case-control studies and cohort studies, or non-human studies” (p 2)10 RCTs (7875 subjects)
Primary outcomes: Patency of CVCs (risk of occlusion)
Secondary outcomes: Heparin-induced thrombocytopenia, hemorrhage, central venous thrombosis, catheter-related blood stream infection
Copyright © 2017 Canadian Agency for Drugs and Technologies in Health.

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Bookshelf ID: NBK470803
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