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Tran K, Severn M. Blue Light Cystoscopy in Patients with Suspected Non-Muscle Invasive Bladder Carcinoma: A Review of Clinical Utility [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Feb 15.

Cover of Blue Light Cystoscopy in Patients with Suspected Non-Muscle Invasive Bladder Carcinoma: A Review of Clinical Utility

Blue Light Cystoscopy in Patients with Suspected Non-Muscle Invasive Bladder Carcinoma: A Review of Clinical Utility [Internet].

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Conclusions and Implications for Decision or Policy Making

Low to moderate quality evidence from recent SRs has suggested that TURBT guided by fluorescent or “blue light” cystoscopy using HAL as photosensitizing agent in the detection and resection of NMIBC was associated with a decreased risk of bladder cancer recurrence and a decreased risk of progression to muscle invasive bladder cancer compared to white light cystoscopy. The effects on recurrence and progression were not statistically significant in trials that used 5-ALA. The effects of fluorescent cystoscopy on mortality were inconclusive due to sparse data. More studies are needed with better study designs and longer term follow-up to understand the impact of HAL-based TURBT on recurrence, progression and survival in patients with different NMIBC risks, different tumor grading systems and different treatment strategies.

Copyright © 2017 Canadian Agency for Drugs and Technologies in Health.

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Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

Bookshelf ID: NBK447636
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