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Dexmedetomidine for Sedation in the ICU or PICU: A Review of Cost-Effectiveness and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Dec 17.

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Dexmedetomidine for Sedation in the ICU or PICU: A Review of Cost-Effectiveness and Guidelines [Internet].

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CONCLUSIONS AND IMPLICATIONS FOR DECISION OR POLICY MAKING

This report aimed to evaluate the cost-effectiveness and the evidence-based guidelines of using dexmedetomidine in the intensive care unit. A total of six economic analyses and two guidelines were retrieved.

With respect to the cost-effectiveness, dexmedetomidine was compared with propofol and midazolam in the included studies. All except one study showed that dexmedetomidine reduced the total hospital costs and the ICU costs. However, when the benefits were evaluated in terms of length of ICU stay or total hospital stay, the results were not consistent. This was reflected with very limited gain in terms of quality adjusted life-years.

The included guidelines suggested that the use of dexmedetomidine might be preferred over the benzodiazepine sedatives for better clinical outcomes and lower risk of delirium. However, the reported recommendations did not declare a preference for dexmedetomidine over propofol.

Copyright © 2014 Canadian Agency for Drugs and Technologies in Health.

Copyright: This report contains CADTH copyright material and may contain material in which a third party owns copyright. This report may be used for the purposes of research or private study only. It may not be copied, posted on a web site, redistributed by email or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner.

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Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial- NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

Bookshelf ID: NBK268696
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