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Montelukast for Sleep Apnea: A Review of the Clinical Effectiveness, Cost Effectiveness, and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Jan 17.

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Montelukast for Sleep Apnea: A Review of the Clinical Effectiveness, Cost Effectiveness, and Guidelines [Internet].

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CONCLUSIONS AND IMPLICATIONS FOR DECISION OR POLICY MAKING

According to one RCT, oral montelukast appears to be effective at improving respiratory disturbances in children with mild to moderate OSA as determined by improvements in AHI and OAI scores. The effect of these improvements on quality of life outcomes was not evaluated.

No published trials regarding the use of montelukast in adults with OSA were identified in this review. There is one study in adult patients with OSA that is comparing the use of oral montelukast in combination with budesonide nasal spray to placebo that was expected to be completed in December 2013.9

No published trials comparing montelukast to other active treatments were identified in this review. One study comparing montelukast to budesonide nasal spray in children with mild to moderate OSA that appears to be completed with no published results.10

No evidence was identified regarding the cost effectiveness of montelukast for the treatment of sleep apnea. No evidence-based guidelines were identified regarding the use of montelukast for the treatment of sleep apnea.

Copyright © 2014 Canadian Agency for Drugs and Technologies in Health.

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Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial- NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

Bookshelf ID: NBK195650
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