Proton pump inhibitors (PPIs) decrease gastric acid and gastric secretory volume. PPIs are used to treat peptic ulcers (duodenal and gastric), symptoms of gastroesophageal reflux disease (GERD), erosive esophagitis, and drug-induced ulcers (e.g., non-steroidal anti-inflammatory drugs {NSAIDs}). The purpose of this review is to compare the benefits and harms of different PPIs.

Contents

• Introduction
  • Scope and Key Questions
• Methods
  • Literature Search
  • Study Selection
  • Data Abstraction
  • Validity Assessment
  • Data Synthesis
• Results
  • Overview
  • Key Question 1. Efficacy in GERD
  • Key Question 2. Efficacy in peptic ulcer and NSAID-induced ulcer?
  • Key Question 3. Adverse effects
  • Key Question 4. Subgroups
• Overall Summary
• References
• Appendixes
  • Appendix A. Search Strategy
  • Appendix B. Quality assessment methods for drug class reviews for DERP
  • Appendix C. Placebo-controlled randomized trials of PPIs (not included)
  • Appendix D. Abstract-only studies (not included)
  • Appendix E. Results of search and selection of included articles
  • Appendix F. Esophagitis grading scales used in randomized controlled trials
  • Appendix G. Studies Currently Under Review / In-Process
• Evidence Tables

The funding source, the Center for Evidence-based Policy, is supported by 17 organizations, including 15 state Medicaid programs. These organizations selected the topic and had input into the Key Questions for this review. The content and conclusions of the review are entirely determined by the Evidence-based Practice Center researchers. The authors of this report have no financial interest in any company that makes or distributes the products reviewed in this report.

Suggested citation:

McDonagh MS, Carson S. Drug Class Review on Proton Pump Inhibitors. 2006. http://www.ohsu.edu/drugeffectiveness/reports/final.cfm

The purpose of this report is to make available information regarding the comparative effectiveness and safety profiles of different drugs within pharmaceutical classes. Reports are not usage guidelines, nor should they be read as an endorsement of, or recommendation for, any particular drug, use or approach. Oregon Health & Science University does not recommend or endorse any guideline or recommendation developed by users of these reports.