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Young C, Sinclair A, Black C, et al. Internet-Delivered Cognitive Behavioural Therapy for Post-Traumatic Stress Disorder: A Health Technology Assessment [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2019 Dec. (CADTH Optimal Use Report, No. 9.3b.)

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Internet-Delivered Cognitive Behavioural Therapy for Post-Traumatic Stress Disorder: A Health Technology Assessment [Internet].

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Appendix 9Clinical Efficacy of Guided Internet-Delivered Cognitive Behavioural Therapy Versus Wait-List

In order to support the scenario analysis of guided internet-delivered cognitive behavioural therapy (iCBT) compared with wait-list or usual care, findings from the CADTH clinical review were reanalyzed using the six studies that examined nurse- or therapist-guided iCBT programs, excluding data from the two studies on PTSD Coach, an unguided iCBT program. This very low-quality evidence indicated that guided iCBT was more effective than wait-list or usual care for severity of post-traumatic stress disorder symptoms at post-treatment (standard mean deviation [95% confidence interval] = −0.80 [−1.18 to −0.42]; participants = 391; randomized controlled trials = 6; I2 = 65%; Figure 17). Although this analysis was not conducted as part of the Cochrane review, these results were used for scenario analyses in the economic section of this health technology assessment.

Figure 17. Comparison of Guided Internet-Delivered Cognitive Behavioural Therapy and Wait-List; Outcome: Severity of Post-Traumatic Stress Disorder Symptoms (Post-Treatment).

Figure 17Comparison of Guided Internet-Delivered Cognitive Behavioural Therapy and Wait-List; Outcome: Severity of Post-Traumatic Stress Disorder Symptoms (Post-Treatment)

CI = confidence interval; iCBT = internet-delivered cognitive behavioural therapy; IV = inverse variance; SD = standard deviation; Std. = standard; WL = wait-list.

Source: Lewis et al. (2018).40

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Bookshelf ID: NBK554853
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