Literature Search Strategy

Dr. Yi-Sheng Chao; Michelle Clark; Elizabeth Carson; Dr. Laura Weeks; Kristen Moulton; Dr. Susan McFaul; Dr. C.M McLauchlin; Dr. Bernice Tsoi; Umair Majid; Sujane Kandasamy; Neha Arora; Dr. Meredith Vanstone; Dr. Lynette Reid; Timothy Krahn; Kasia Kaluzny; Kelly Farrah; Caitlyn Ford

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Chao YS, Clark M, Carson E, et al. HPV Testing for Primary Cervical Cancer Screening: A Health Technology Assessment [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2019 Mar. (CADTH Optimal Use Report, No. 7.1b.)

Cover of HPV Testing for Primary Cervical Cancer Screening: A Health Technology Assessment

HPV Testing for Primary Cervical Cancer Screening: A Health Technology Assessment [Internet].

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Appendix 1Literature Search Strategy

Clinical Database Search

OVERVIEW
Interface:	Ovid
Databases:	EBM Reviews - Cochrane Central Register of Controlled Trials January 2017 EBM Reviews - Cochrane Database of Systematic Reviews 2005 to Present EBM Reviews - Database of Abstracts of Reviews of Effects 1st Quarter 2016 Embase 1974 to Present Ovid MEDLINE 1946 to Present Ovid MEDLINE Epub Ahead of Print, In-Process & Other Non-Indexed Citations Note: Subject headings have been customized for each database. Duplicates between databases were removed in Ovid.
Date of Search:	February 24, 2017
Alerts:	Monthly search updates until project completion.
Study Types:	No filters used.
Limits:	Language limit: English- and French-language Date limit: 2002 - present Conference abstracts excluded
SYNTAX GUIDE
/	At the end of a phrase, searches the phrase as a subject heading
MeSH	Medical Subject Heading
exp	Explode a subject heading
*	Before a word, indicates that the marked subject heading is a primary topic; or, after a word, a truncation symbol (wildcard) to retrieve plurals or varying endings
adj#	Adjacency within # number of words (in any order)
.ti	Title
.ab	Abstract
.hw	Heading Word; usually includes subject headings and controlled vocabulary
.kf	Author keyword heading word (MEDLINE)
.kw	Author keyword (Embase, Cochrane, DARE)
.dm	Device manufacturer (Embase)
.dv	Device trade name (Embase)
/di	Diagnosis subheading (MEDLINE, Embase)
/ip	Isolation & purification subheading (MEDLINE)
/ge	Genetics subheading (MEDLINE)
ppez	Ovid database code; Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to Present
oemezd	Ovid database code; Embase 1974 to present, updated daily
cctr	Ovid database code; Cochrane Central Register of Controlled Trials
dare	Ovid database code; Database of Abstracts of Reviews of Effects
coch	Ovid database code; Cochrane Database of Systematic Reviews

MULTI-DATABASE STRATEGY
#	Clinical Search Strategy
1	Human Papillomavirus DNA Tests/
2	DNA Probes, HPV/
3	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (test or assay* or genotyping or typing or detection or amplification)).ti,kf,kw.
4	((HPV* or hrHPV) adj3 (test or assay* or genotyping or typing or detection or amplification)).ab.
5	((Papillomavirus* or Papilloma Virus) adj5 (test or assay* or genotyping or typing or detection or amplification)).ab.
6	(((HPV* or hrHPV) adj3 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,kf,kw.
7	(((Papillomavirus* or Papilloma Virus) adj5 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,kf,kw.
8	Papillomavirus Infections/di
9	or/1-8
10	Papillomaviridae/ip, ge or exp Alphapapillomavirus/ip, ge
11	Papillomavirus Infections/
12	(HPV* or hrHPV* or Papillomavirus* or Papilloma Virus*).ti,kf,kw.
13	or/10-12
14	Molecular Diagnostic Techniques/
15	Nucleic Acid Amplification Techniques/
16	exp *Polymerase Chain Reaction/
17	DNA Methylation/
18	Genotyping Techniques/
19	exp Nucleic Acid Hybridization/
20	exp Nucleic Acid Probes/
21	(polymerase chain reaction or PCR or methylation or genotyping or hybridization or probe*).ti,kf,kw.
22	(molecular adj2 (screen* or diagnos*)).ti,ab,kf,kw.
23	or/14-22
24	13 and 23
25	(GenoArray or Geno-Array or Cobas or Aptima or Linear Array or LinearArray or RealTime or Hybrid Capture or HybridCapture or HC2 or HC 2 or HCII or HC II or Xpert or Amplicor or Inno-LiPa or InnoLiPa or PreTect or Pre-Tect or Euro-Array or EuroArray or OncoTect or Onco-Tect or OncoE6 or Quantivirus or Cervical Sampler or CervicalSampler or Delphi Screener or DelphiScreener or PapType or Anyplex or SoloPap or Solo-Pap or Onclarity).ti,ab,kf,kw.
26	(Digene or Roche or Hologic or Abbott or Quigen or Arbor Vita or Breakspear or DAAN Gene or DiaCarta or Fujirebio or Genera Biosystems or IncellDx or Seegene or Trovagene).ti,ab,kf,kw.
27	(HPV* or hrHPV* or Papillomavirus* or Papilloma Virus*).ti,ab,kf,kw,hw.
28	(25 or 26) and 27
29	(Cervista or CINtec or CIN-tec or HPV28 or HPV-28 or PapilloCheck or Papillo-Check or careHPV).ti,ab,kf,kw.
30	28 or 29
31	Cervical Intraepithelial Neoplasia/
32	Uterine Cervical Neoplasms/
33	Uterine Cervical Dysplasia/
34	Atypical Squamous Cells of the Cervix/
35	Cervix Uteri/
36	Vaginal Smears/
37	(cervical or cervix or cervixes or cervico*).ti,kf,kw.
38	((cervical or cervix or cervixes or cervico) adj5 (precancer or cancer* or neoplas* or dysplas* or dyskaryos* or tumor* or tumour* or malignanc* or carcinoma* or adenocarcinoma* or lesion* or squamous or small cell or large cell)).ti,ab,kf,kw.
39	(atypical glandular cell* or AGC or AGUS).ti,ab,kf,kw.
40	(CIN or CINII* or CIN2* or CINIII* or CIN3* or SIL or HSIL or LSIL or ASCUS or AS-CUS).ti,ab,kf,kw.
41	((pap or papanicolaou or vagina* or cervical or cervix or cervixes or cervico) adj3 (smear or test* or swab* or scrap*)).ti,ab,kf,kw.
42	or/31-41
43	Mass Screening/
44	“Direct-To-Consumer Screening and Testing”/
45	Early Detection of Cancer/
46	Triage/
47	(screen* or triage* or triaging or reflex).ti,ab,kf,kw.
48	(detect* or test* or diagnos* or identify* or identifi* or predict*).ti,kf,kw.
49	or/43-48
50	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (screen or triage* or triaging or reflex)).ti,kf,kw.
51	((HPV* or hrHPV) adj3 (screen or triage* or triaging or reflex)).ab.
52	((Papillomavirus* or Papilloma Virus) adj5 (screen or triage* or triaging or reflex)).ab.
53	or/50-52
54	(9 or 24) and 42 and 49
55	30 and 49
56	42 and 53
57	or/54-56
58	“Sensitivity and Specificity”/
59	“Limit of Detection”/
60	ROC Curve/
61	Diagnostic Errors/
62	False Negative Reactions/
63	False Positive Reactions/
64	“Predictive Value of Tests”/
65	diagnostic accuracy/
66	receiver operating characteristic/
67	exp diagnostic error/
68	predictive value/
69	diagnostic value/
70	diagnostic test accuracy study/
71	“Diagnostic Uses of Chemicals”/
72	(Sensitivity or specificity).ti,ab,kw,kf.
73	(false adj2 (positive* or negative*)).ti,ab,kw,kf.
74	((positive* or negative*) adj2 (predictive or likelihood)).ti,ab,kw,kf.
75	(predictive valu* or validit*).ti,ab,kw,kf.
76	(receiver adj2 operating).ti,ab,kw,kf.
77	(ROC or AUROC* or SROC or HSROC).ti,ab,kw,kf.
78	((under or over) adj2 curve*).ti,ab,kw,kf.
79	(detect* adj2 (abilit* or rate*)).ti,ab,kw,kf.
80	((gold* or reference) adj2 standard).ti,ab,kw,kf.
81	((test or diagnos) adj2 (perform or accura* or value* or “use” or useful or usefulness or utilit* or effica* or compar* or evaluat*)).ti,ab,kw,kf.
82	or/58-80
83	(9 or 24) and 42 and 82
84	(30 or 53) and 82
85	83 or 84
86	57 or 85
87	86 use ppez
88	86 use cctr
89	9 or 24 or 30 or 53
90	89 use dare
91	89 use coch
92	Human papillomavirus DNA test/
93	exp nucleic acid probe/ and (HPV* or hrHPV* or Papillomavirus* or Papilloma Virus*).ti,ab,kw,hw.
94	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (test or assay* or genotyping or typing or detection or amplification)).ti,kw.
95	((HPV* or hrHPV) adj3 (test or assay* or genotyping or typing or detection or amplification)).ab.
96	((Papillomavirus* or Papilloma Virus) adj5 (test or assay* or genotyping or typing or detection or amplification)).ab.
97	(((HPV* or hrHPV) adj3 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,kw.
98	(((Papillomavirus* or Papilloma Virus) adj5 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,kw.
99	papillomavirus infection/di
100	or/92-99
101	Papillomaviridae/
102	exp Alphapapillomavirus/
103	papillomavirus infection/
104	Wart virus/
105	(HPV* or hrHPV* or Papillomavirus* or Papilloma Virus*).ti,kw.
106	or/101-105
107	molecular diagnosis/
108	exp *polymerase chain reaction/
109	DNA Methylation/
110	Genotyping Technique/
111	nucleic acid hybridization/
112	exp nucleic acid probe/
113	nucleic acid amplification/
114	(polymerase chain reaction or PCR or methylation or genotyping or hybridization or probe*).ti,kw.
115	(molecular adj2 (screen* or diagnos*)).ti,ab,kw.
116	or/107-115
117	106 and 116
118	(GenoArray or Geno-Array or Cobas or Aptima or Linear Array or LinearArray or RealTime or Hybrid Capture or HybridCapture or HC2 or HC 2 or HCII or HC II or Xpert or Amplicor or Inno-LiPa or InnoLiPa or PreTect or Pre-Tect or Euro-Array or EuroArray or OncoTect or Onco-Tect or OncoE6 or Quantivirus or Cervical Sampler or CervicalSampler or Delphi Screener or DelphiScreener or PapType or Anyplex or SoloPap or Solo-Pap or Onclarity).ti,ab,kw,dv,hw.
119	(Digene or Roche or Hologic or Abbott or Quigen or Arbor Vita or Breakspear or DAAN Gene or DiaCarta or Fujirebio or Genera Biosystems or IncellDx or Seegene or Trovagene).ti,ab,kw,dm.
120	(HPV* or hrHPV* or Papillomavirus* or Papilloma Virus*).ti,ab,kw,hw.
121	(118 or 119) and 120
122	(Cervista or CINtec or CIN-tec or HPV28 or HPV-28 or PapilloCheck or Papillo-Check or careHPV).ti,ab,kw,dv,hw.
123	121 or 122
124	uterine cervix disease/
125	uterine cervix dysplasia/
126	squamous intraepithelial lesion of the cervix/
127	uterine cervix tumor/
128	uterine cervix cancer/
129	uterine cervix carcinoma/
130	uterine cervix carcinoma in situ/
131	uterine cervix cytology/
132	exp uterine cervix/
133	vagina smear/
134	(cervical or cervix or cervixes or cervico*).ti,kw.
135	((cervical or cervix or cervixes or cervico) adj5 (precancer or cancer* or neoplas* or dysplas* or dyskaryos* or tumor* or tumour* or malignanc* or carcinoma* or adenocarcinoma* or lesion* or squamous or small cell or large cell)).ti,ab,kw.
136	(atypical glandular cell* or AGC or AGUS).ti,ab,kw.
137	(CIN or CINII* or CIN2* or CINIII* or CIN3* or SIL or HSIL or LSIL or ASCUS or AS-CUS).ti,ab,kw.
138	((pap or papanicolaou or vagina* or cervical or cervix or cervixes or cervico) adj3 (smear or test* or swab* or scrap*)).ti,ab,kw.
139	or/124-138
140	screening/
141	mass screening/
142	cancer screening/
143	screening test/
144	DNA screening/
145	early cancer diagnosis/
146	(screen* or triage* or triaging or reflex).ti,ab,kw.
147	(detect* or test* or diagnos* or identify* or identifi* or predict*).ti,kw.
148	or/140-147
149	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (screen or triage* or triaging or reflex)).ti,kw.
150	((HPV* or hrHPV) adj3 (screen or triage* or triaging or reflex)).ab
151	((Papillomavirus* or Papilloma Virus) adj5 (screen or triage* or triaging or reflex)).ab
152	or/149-151
153	(100 or 117) and 139 and 148
154	123 and 148
155	139 and 152
156	153 or 154 or 155
157	(100 or 117) and 139 and 82
158	123 and 82
159	152 and 82
160	157 or 158 or 159
161	156 or 160
162	161 use oemezd
163	162 not conference abstract.pt.
164	87 or 88 or 90 or 91 or 163
165	limit 164 to (english or french) [Limit not valid in CDSR,DARE; records were retained]
166	limit 165 to yr=“2002 -Current” [Limit not valid in DARE; records were retained]
167	limit 166 to yr=“2002 - 2010” [Limit not valid in DARE; records were retained]
168	remove duplicates from 167
169	166
170	limit 169 to yr=“2011 - 2014” [Limit not valid in DARE; records were retained]
171	remove duplicates from 170
172	169
173	limit 172 to yr=“2015 -Current” [Limit not valid in DARE; records were retained]
174	remove duplicates from 173
175	168 or 171 or 174

OTHER DATABASES
PubMed	A limited PubMed search was performed to capture records not found in MEDLINE. Same MeSH, keywords, and limits used as per MEDLINE search, with appropriate syntax used.

Patients’ Perspectives and Experience Database Search

OVERVIEW
Interface:	Ovid
Databases:	Embase 1974 to present Ovid MEDLINE 1946 to Present Ovid MEDLINE Epub Ahead of Print, In-Process & Other Non-Indexed Citations PsycINFO 1967 to present Note: Subject headings have been customized for each database. Duplicates between databases were removed in Ovid.
Date of Search:	HPV testing search: January 20, 2017 Cervical cancer screening search: February 6, 2017
Alerts:	Monthly search updates until project completion.
Study Types:	Qualitative literature
Limits:	Language limit: English- and French-language Conference abstracts excluded HPV testing search: No date limits Cervical cancer screening search: 2002-Present
SYNTAX GUIDE
/	At the end of a phrase, searches the phrase as a subject heading
MeSH	Medical Subject Heading
exp	Explode a subject heading
*	Before a word, indicates that the marked subject heading is a primary topic; or, after a word, a truncation symbol (wildcard) to retrieve plurals or varying endings
$	A truncation symbol (wildcard) to retrieve plurals or varying endings
?	Truncation symbol for one or no characters only
adj#	Adjacency within # number of words (in any order)
.ti	Title
.ab	Abstract
.hw	Heading word; usually includes subject headings and controlled vocabulary
.mp	Multi-purpose; searches several fields at once including Title, Original Title, Abstract, Subject Heading, Name of Substance, and Registry Word fields
.af	All fields
.tw	Textword; searches all of the fields in a database which contain text words and which are appropriate for a subject search
.kf	Author keyword heading word (MEDLINE)
.kw	Author keyword (Embase)
.id	Key concepts (PsycINFO)
.pt	Publication type
.dm	Device manufacturer (Embase)
.dv	Device trade name (Embase)
/di	Diagnosis subheading (MEDLINE, Embase)
/ip	Isolation & purification subheading (MEDLINE)
/ge	Genetics subheading (MEDLINE)
pmez	Ovid database code; MEDLINE In-Process & Other Non-Indexed Citations, MEDLINE Daily and Ovid MEDLINE 1946 to Present
oemezd	Ovid database code; Embase 1974 to present, updated daily
psyb	Ovid database code; PsycINFO 1967 to present

MULTI-DATABASE STRATEGY
#	Patients’ Perspectives and Experience Search Strategy
Search #1: HPV Testing
1	Human Papillomavirus DNA Tests/
2	DNA Probes, HPV/
3	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (test or assay* or genotyping or typing or detection or amplification)).ti,kf.
4	((HPV* or hrHPV) adj3 (test or assay* or genotyping or typing or detection or amplification)).ab.
5	((Papillomavirus* or Papilloma Virus) adj5 (test or assay* or genotyping or typing or detection or amplification)).ab.
6	(((HPV* or hrHPV) adj3 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,kf.
7	(((Papillomavirus* or Papilloma Virus) adj5 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,kf.
8	Papillomavirus Infections/di
9	or/1-8
10	Papillomaviridae/ip, ge or exp Alphapapillomavirus/ip, ge
11	Papillomavirus Infections/
12	(HPV* or hrHPV* or Papillomavirus* or Papilloma Virus*).ti,kf.
13	or/10-12
14	Molecular Diagnostic Techniques/
15	Nucleic Acid Amplification Techniques/
16	exp *Polymerase Chain Reaction/
17	DNA Methylation/
18	Genotyping Techniques/
19	exp Nucleic Acid Hybridization/
20	exp Nucleic Acid Probes/
21	(polymerase chain reaction or PCR or methylation or genotyping or hybridization or probe*).ti,kf.
22	(molecular adj2 (screen* or diagnos*)).ti,ab,kf.
23	or/14-22
24	13 and 23
25	(GenoArray or Geno-Array or Cobas or Aptima or Linear Array or LinearArray or RealTime or Hybrid Capture or HybridCapture or HC2 or HC 2 or HCII or HC II or Xpert or Amplicor or Inno-LiPa or InnoLiPa or PreTect or Pre-Tect or Euro-Array or EuroArray or OncoTect or Onco-Tect or OncoE6 or Quantivirus or Cervical Sampler or CervicalSampler or Delphi Screener or DelphiScreener or PapType or Anyplex or SoloPap or Solo-Pap or Onclarity).ti,ab,kf.
26	(Digene or Roche or Hologic or Abbott or Quigen or Arbor Vita or Breakspear or DAAN Gene or DiaCarta or Fujirebio or Genera Biosystems or IncellDx or Seegene or Trovagene).ti,ab,kf.
27	(HPV* or hrHPV* or Papillomavirus* or Papilloma Virus*).ti,ab,kf,hw.
28	(25 or 26) and 27
29	(Cervista or CINtec or CIN-tec or HPV28 or HPV-28 or PapilloCheck or Papillo-Check or careHPV).ti,ab,kf.
30	28 or 29
31	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (screen or triage* or triaging or reflex or self-sampl* or selfsampl* or self-collect* or selfcollect*)).ti,kf.
32	((HPV* or hrHPV) adj3 (screen or triage* or triaging or reflex or self-sampl* or selfsampl* or self-collect* or selfcollect*)).ab.
33	((Papillomavirus* or Papilloma Virus) adj5 (screen or triage* or triaging or reflex or self-sampl* or selfsampl* or self-collect* or selfcollect*)).ab.
34	or/31-33
35	9 or 24 or 30 or 34
36	35 use ppez
37	Human papillomavirus DNA test/
38	exp nucleic acid probe/ and (HPV* or hrHPV* or Papillomavirus* or Papilloma Virus*).ti,ab,kw,hw.
39	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (test or assay* or genotyping or typing or detection or amplification)).ti,kw.
40	((HPV* or hrHPV) adj3 (test or assay* or genotyping or typing or detection or amplification)).ab.
41	((Papillomavirus* or Papilloma Virus) adj5 (test or assay* or genotyping or typing or detection or amplification)).ab.
42	(((HPV* or hrHPV) adj3 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,kw.
43	(((Papillomavirus* or Papilloma Virus) adj5 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,kw.
44	papillomavirus infection/di
45	or/37-44
46	Papillomaviridae/
47	exp Alphapapillomavirus/
48	papillomavirus infection/
49	wart virus/
50	(HPV* or hrHPV* or Papillomavirus* or Papilloma Virus*).ti,kw.
51	or/46-50
52	molecular diagnosis/
53	exp *polymerase chain reaction/
54	DNA Methylation/
55	Genotyping Technique/
56	nucleic acid hybridization/
57	exp nucleic acid probe/
58	nucleic acid amplification/
59	(polymerase chain reaction or PCR or methylation or genotyping or hybridization or probe*).ti,kw.
60	(molecular adj2 (screen* or diagnos*)).ti,ab,kw.
61	or/52-60
62	51 and 61
63	(GenoArray or Geno-Array or Cobas or Aptima or Linear Array or LinearArray or RealTime or Hybrid Capture or HybridCapture or HC2 or HC 2 or HCII or HC II or Xpert or Amplicor or Inno-LiPa or InnoLiPa or PreTect or Pre-Tect or Euro-Array or EuroArray or OncoTect or Onco-Tect or OncoE6 or Quantivirus or Cervical Sampler or CervicalSampler or Delphi Screener or DelphiScreener or PapType or Anyplex or SoloPap or Solo-Pap or Onclarity).ti,ab,kw,dv,hw.
64	(Digene or Roche or Hologic or Abbott or Quigen or Arbor Vita or Breakspear or DAAN Gene or DiaCarta or Fujirebio or Genera Biosystems or IncellDx or Seegene or Trovagene).ti,ab,kw,dm.
65	(HPV* or hrHPV* or Papillomavirus* or Papilloma Virus*).ti,ab,kw,hw.
66	(63 or 64) and 65
67	(Cervista or CINtec or CIN-tec or HPV28 or HPV-28 or PapilloCheck or Papillo-Check or careHPV).ti,ab,kw,dv,hw.
68	66 or 67
69	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (screen or triage* or triaging or reflex or self-sampl* or selfsampl* or self-collect* or selfcollect*)).ti,kw.
70	((HPV* or hrHPV) adj3 (screen or triage* or triaging or reflex or self-sampl* or selfsampl* or self-collect* or selfcollect*)).ab.
71	((Papillomavirus* or Papilloma Virus) adj5 (screen or triage* or triaging or reflex or self-sampl* or selfsampl* or self-collect* or selfcollect*)).ab.
72	or/69-71
73	45 or 62 or 66 or 72
74	73 use oemezd
75	Human Papillomavirus/
76	(HPV* or hrHPV* or Papillomavirus* or Papilloma Virus*).ti,ab,id.
77	or/75-76
78	exp Nucleic Acids/ or Cancer Screening/ or Diagnosis/ or Genotypes/
79	(screen* or triage* or triaging or reflex or self-sampl* or selfsampl* or self-collect* or selfcollect*).ti,ab,id.
80	(polymerase chain reaction or PCR or methylation or genotyping or hybridization or probe*).ti,ab,id.
81	(GenoArray or Geno-Array or Cobas or Aptima or Linear Array or LinearArray or RealTime or Hybrid Capture or HybridCapture or HC2 or HC 2 or HCII or HC II or Xpert or Amplicor or Inno-LiPa or InnoLiPa or PreTect or Pre-Tect or Euro-Array or EuroArray or OncoTect or Onco-Tect or OncoE6 or Quantivirus or Cervical Sampler or CervicalSampler or Delphi Screener or DelphiScreener or PapType or Anyplex or SoloPap or Solo-Pap or Onclarity).ti,ab,id.
82	(Digene or Roche or Hologic or Abbott or Quigen or Arbor Vita or Breakspear or DAAN Gene or DiaCarta or Fujirebio or Genera Biosystems or IncellDx or Seegene or Trovagene).ti,ab,id.
83	or/78-82
84	77 and 83
85	(Cervista or CINtec or CIN-tec or HPV28 or HPV-28 or PapilloCheck or Papillo-Check or careHPV).ti,ab,id.
86	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (test or assay* or genotyping or typing or detection or amplification)).ti,id.
87	((HPV* or hrHPV) adj3 (test or assay* or genotyping or typing or detection or amplification)).ab.
88	((Papillomavirus* or Papilloma Virus) adj5 (test or assay* or genotyping or typing or detection or amplification)).ab.
89	(((HPV* or hrHPV) adj3 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,id.
90	(((Papillomavirus* or Papilloma Virus) adj5 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,id.
91	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) adj3 diagnos).ti,ab,id.
92	or/85-91
93	84 or 92
94	93 use psyb
Qualitative Filter
95	Qualitative Research/ or Interview/ or Interviews as Topic/ or Personal Narratives/ or Focus Groups/ or Narration/ or Nursing Methodology Research/
96	95 use ppez
97	qualitative research/ or qualitative analysis/ or exp interview/ or nursing methodology research/ or narrative/ or storytelling/
98	97 use oemezd
99	Qualitative research/ or Interviews/ or Storytelling/
100	99 use psyb
101	interview$.mp.
102	(theme$ or thematic).mp.
103	qualitative.af.
104	questionnaire$.mp.
105	ethnological research.mp.
106	ethnograph$.mp.
107	ethnonursing.af.
108	phenomenol$.af.
109	(grounded adj (theor$ or study or studies or research or analys?s)).af.
110	(life stor$ or women* stor$).mp.
111	(emic or etic or hermeneutic$ or heuristic$ or semiotic$).af. or (data adj1 saturat$).tw. or participant observ$.tw.
112	(social construct$ or postmodern$ or post-structural$ or post structural$ or poststructural$ or post modern$ or post-modern$ or feminis$).mp.
113	(action research or cooperative inquir$ or co operative inquir$ or co-operative inquir$).mp.
114	(humanistic or existential or experiential or paradigm$).mp.
115	(field adj (study or studies or research)).tw.
116	human science.tw.
117	biographical method.tw.
118	theoretical sampl$.af.
119	((purpos$ adj4 sampl$) or (focus adj group$)).af.
120	(account or accounts or unstructured or open-ended or open ended or text$ or narrative$).mp.
121	(life world or life-world or conversation analys?s or personal experience$ or theoretical saturation).mp.
122	((lived or life) adj experience$).mp.
123	cluster sampl$.mp.
124	observational method$.af.
125	content analysis.af.
126	(constant adj (comparative or comparison)).af.
127	((discourse$ or discurs$) adj3 analys?s).tw.
128	narrative analys?s.af.
129	heidegger$.tw.
130	colaizzi$.tw.
131	spiegelberg$.tw.
132	(van adj manen$).tw.
133	(van adj kaam$).tw.
134	(merleau adj ponty$).tw.
135	husserl$.tw.
136	foucault$.tw.
137	(corbin$ adj2 strauss$).tw.
138	glaser$.tw.
139	or/96,98,100-138
140	36 or 74 or 94
141	139 and 140
142	141 not conference abstract.pt.
143	limit 142 to (english or french)
144	remove duplicates from 143 [Results for Search #1: HPV Testing]
Search #2: Cervical Cancer Screening
145	Mass Screening/
146	“Direct-To-Consumer Screening and Testing”/
147	Early Detection of Cancer/
148	(screen* or triage* or triaging or smear* or test*).ti,kf.
149	or/145-148
150	Cervical Intraepithelial Neoplasia/
151	Uterine Cervical Neoplasms/
152	Uterine Cervical Dysplasia/
153	Atypical Squamous Cells of the Cervix/
154	Vaginal Smears/
155	Papanicolaou Test/
156	(cervical or cervix or cervixes or cervico* or pap or papanicolaou or vagina*).ti,kf.
157	or/150-156
158	149 and 157
159	((pap or papanicolaou or cervical or cervix or cervixes or cervico) adj5 (screen or triage* or triaging or smear* or test*)).ab.
160	158 or 159
161	160 use ppez
162	uterine cervix disease/
163	uterine cervix dysplasia/
164	squamous intraepithelial lesion of the cervix/
165	uterine cervix tumor/
166	uterine cervix carcinoma/
167	uterine cervix carcinoma in situ/
168	uterine cervix cytology/
169	exp uterine cervix/
170	vagina smear/
171	Papanicolaou test/
172	(cervical or cervix or cervixes or cervico* or pap or papanicolaou or vagina*).ti,kw.
173	or/162-172
174	screening/
175	mass screening/
176	cancer screening/
177	screening test/
178	DNA screening/
179	early cancer diagnosis/
180	(screen* or triage* or triaging or smear* or test*).ti,kf.
181	or/174-180
182	173 and 181
183	((pap or papanicolaou or cervical or cervix or cervixes or cervico) adj5 (screen or triage* or triaging or smear* or test*)).ab.
184	182 or 183
185	184 use oemezd
186	((cervical or cervix or cervixes or cervico* or pap or papanicolaou or vagina) and (screen or triage* or triaging or smear* or test*)).ti,id.
187	((pap or papanicolaou or cervical or cervix or cervixes or cervico) adj5 (screen or triage* or triaging or smear* or test*)).ab.
188	186 or 187
189	188 use psyb
190	161 or 185 or 189
191	139 and 190
192	191 not 141
193	192 not conference abstract.pt.
194	limit 193 to (english or french)
195	limit 194 to yr=“2002 -Current”
196	remove duplicates from 195 [duplicates removed from search #1]

OTHER DATABASES
PubMed	A limited PubMed search was performed to capture records not found in MEDLINE. Same MeSH, keywords, and limits used as per MEDLINE search, with appropriate syntax used.
CINAHL	Same keywords, and limits used as per MEDLINE search. Syntax adjusted for EBSCO platform. MEDLINE records excluded.
Scopus	Same keywords and limits used as per MEDLINE search, with appropriate syntax used. Limited to subject areas: Social Sciences, Multidisciplinary, Psychology, Arts & Humanities.

Ethics Database Search

OVERVIEW
Interface:	Ovid
Databases:	Ovid MEDLINE 1946 to Present Ovid MEDLINE Epub Ahead of Print, In-Process & Other Non-Indexed Citations PsycINFO 1967 to Present Note: Subject headings have been customized for each database. Duplicates between databases were removed in Ovid.
Date of Search:	HPV testing search: February 9, 2017 Cervical cancer screening search: March 3, 2017
Alerts:	Monthly search updates until project completion.
Study Types:	No study design filters used.
Limits:	Language limit: English- and French-language
SYNTAX GUIDE
/	At the end of a phrase, searches the phrase as a subject heading
MeSH	Medical Subject Heading
exp	Explode a subject heading
*	Before a word, indicates that the marked subject heading is a primary topic; or, after a word, a truncation symbol (wildcard) to retrieve plurals or varying endings
adj#	Adjacency within # number of words (in any order)
SYNTAX GUIDE
.ti	Title
.ab	Abstract
.hw	Heading word; usually includes subject headings and controlled vocabulary
.kf	Author keyword heading word (MEDLINE)
.id	Key concepts (PsycINFO)
.fs	Floating sub-heading
.jw	Journal word
ppez	Ovid database code; Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to Present
psyb	PsycINFO database code; PsycINFO 1967 to February Week 1 2017

MULTI-DATABASE STRATEGY
#	Ethics Database Search Strategy
Search #1: HPV Testing
1	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (screen or triage* or triaging or reflex or self-sampl* or selfsampl* or self-collect* or selfcollect*)).ti,kf.
2	((HPV* or hrHPV) adj3 (screen or triage* or triaging or reflex or self-sampl* or selfsampl* or self-collect* or selfcollect*)).ab.
3	((Papillomavirus* or Papilloma Virus) adj5 (screen or triage* or triaging or reflex or self-sampl* or selfsampl* or self-collect* or selfcollect*)).ab.
4	Human Papillomavirus DNA Tests/
5	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (test or assay* or genotyping or typing or detection or amplification)).ti,kf.
6	((HPV* or hrHPV) adj3 (test or assay* or genotyping or typing or detection or amplification)).ab.
7	((Papillomavirus* or Papilloma Virus) adj5 (test or assay* or genotyping or typing or detection or amplification)).ab.
8	(((HPV* or hrHPV) adj3 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,kf.
9	(((Papillomavirus* or Papilloma Virus) adj5 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,kf.
10	or/1-9
11	10 use ppez
12	Human Papillomavirus/
13	(HPV* or hrHPV* or Papillomavirus* or Papilloma Virus*).ti,ab,id.
14	or/12-13
15	exp Nucleic Acids/ or Cancer Screening/ or Diagnosis/ or Genotypes/
16	(screen* or triage* or triaging or reflex or self-sampl* or selfsampl* or self-collect* or selfcollect*).ti,ab,id.
17	or/15-16
18	14 and 17
19	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (test or assay* or genotyping or typing or detection or amplification)).ti,id.
20	((HPV* or hrHPV) adj3 (test or assay* or genotyping or typing or detection or amplification)).ab.
21	((Papillomavirus* or Papilloma Virus) adj5 (test or assay* or genotyping or typing or detection or amplification)).ab.
22	(((HPV* or hrHPV) adj3 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,id.
23	(((Papillomavirus* or Papilloma Virus) adj5 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,id.
24	or/18-23
25	24 use psyb
26	11 or 25
Ethics, Legal, Psychosocial Filter
27	exp Ethics/
28	exp Privacy/
29	exp Jurisprudence/
30	exp Morals/
31	Paternalism/
32	exp Prejudice/
33	Social Values/
34	Social Norms/
35	Stereotyping/
36	Social Stigma/
37	exp Geography, Medical/
38	Medically Underserved Area/
39	Health Services Accessibility/
40	Health Equity/
41	Healthcare Disparities/
42	Medical Overuse/
43	exp Disclosure/
44	exp Human Rights/
45	Coercion/
46	exp Mandatory Programs/
47	exp Social Problems/
48	“Legislation & Jurisprudence”.fs.
49	ethics.fs.
50	or/27-49 use ppez
51	exp ethics/
52	exp “law (government)”/
53	privacy/
54	exp social influences/
55	morality/
56	or/51-55
57	56 use psyb
58	((healthcare or health care or nonclinical or community based or public health or preventive care) adj (access or deliver* or distribution* or system*)).ti,kf,id.
59	(ethic or ethics or ethical or moral or morals or bioethic*).ti,ab,hw,kf,jw,id.
60	(legal* or liabilit* or litigation* or constitutional or justice or law or laws or jurisprudence or complicit*).ti,ab,hw,kf,jw,id.
61	(lawsuit* or lawyer* or lawmaker*).ti,ab,kf,id.
62	human right*.ti,ab,kf,id.
63	civil right*.ti,ab,kf,id.
64	(prejudice* or stigma or stigmas or stigmatization or stigmatize or stigmatise or stigmatisation or stereotyp*).ti,ab,kf,id.
65	(inequalit* or equalit* or inequit* or equit* or disparit* or fair or fairness or unfair or unfairness).ti,ab,kf,id.
66	(distributive justice or precautionary principle or solidarity).ti,ab,kf,id.
67	((care or treatment) adj2 (duty or obligat*)).ti,ab,kf,id.
68	(social* adj (responsib* or obligat* or justice)).ti,ab,kf,id.
69	(psychological or psychosocial or socioeconomic or socio-economic or psychosexual).ti,kf,id.
70	((social or psychological or psychosocial or socioeconomic or socio-economic or psychosexual) adj2 (impact* or burden*)).ti,ab,kf,id.
71	(communitarian* or beneficence or non-maleficence or maleficence or accountability).ti,ab,kf,id.
72	(harm or harms or harming or harmful).ti,ab,kf,id.
73	(privacy or confidential*).ti,ab,kf,id.
74	((informed or presumed or shared) adj2 (consent or choice or decision making)).ti,ab,kf,id.
75	(coercion or persuasion or information provision).ti,ab,kf,id.
76	((conflict or financial or industry) adj3 interest*).ti,ab,kf,id.
77	(industry adj3 (funding or involvement or sponsor*)).ti,ab,kf,id.
78	autonomy.ti,ab,hw,kf,id.
79	transparency.ti,ab,kf,id.
80	(overdiagnos* or over-diagnos* or underscreen* or under-screen* or overtreat* or over-treat*).ti,ab,kf,id.
81	underserved.ti,ab,kf,id.
82	or/50,57-81
83	26 and 82
84	limit 83 to (english or french)
85	remove duplicates from 84 [Results for Search #1: HPV Testing]
Search #2: Cervical Cancer Screening
86	Cervical Intraepithelial Neoplasia/
87	Uterine Cervical Neoplasms/
88	Uterine Cervical Dysplasia/
89	Atypical Squamous Cells of the Cervix/
90	Vaginal Smears/
91	Papanicolaou Test/
92	(cervical or cervix or cervixes or cervico* or pap or papanicolaou or vagina*).ti,kf.
93	or/86-92
94	Mass Screening/
95	“Direct-To-Consumer Screening and Testing”/
96	Early Detection of Cancer/
97	Triage/
98	(screen* or triage* or triaging or smear* or test* or cytology).ti,kf.
99	or/94-98
100	93 and 99
101	((pap or papanicolaou or cervical or cervix or cervixes or cervico) adj3 (screen or triage* or triaging or smear* or test* or cytology)).ab.
102	100 or 101
103	102 use ppez
104	((cervical or cervix or cervixes or cervico* or pap or papanicolaou or vagina) and (screen or triage* or triaging or smear* or test* or cytology)).ti,id.
105	((pap or papanicolaou or cervical or cervix or cervixes or cervico) adj3 (screen or triage* or triaging or smear* or test* or cytology)).ab.
106	104 or 105
107	106 use psyb
108	103 or 107
109	82 and 108
110	limit 109 to (english or french)
111	remove duplicates from 110 [Results for Search #2: Cervical Cancer Screening]

OTHER DATABASES
PubMed	A limited PubMed search was performed to capture records not found in MEDLINE. Same MeSH, keywords, and limits used as per MEDLINE search, with appropriate syntax used.
CINAHL	Same keywords, and limits used as per MEDLINE search. Syntax adjusted for EBSCO platform. MEDLINE records excluded.

Implementation Database Search

OVERVIEW
Interface:	Ovid
Databases:	Ovid MEDLINE 1946 to Present Ovid MEDLINE Epub Ahead of Print, In-Process & Other Non-Indexed Citations Embase 1974 to Present Note: Subject headings have been customized for each database. Duplicates between databases were removed in Ovid.
Date of Search:	March 2017
Alerts:	Monthly search updates until project completion.
Study Types:	No study design filters used.
Limits:	Language limit: English- and French-language Date limit: 2002 - Present Conference abstracts excluded
SYNTAX GUIDE
/	At the end of a phrase, searches the phrase as a subject heading
MeSH	Medical Subject Heading
exp	Explode a subject heading
*	Before a word, indicates that the marked subject heading is a primary topic; or, after a word, a truncation symbol (wildcard) to retrieve plurals or varying endings
?	Truncation symbol for one or no characters only
adj#	Adjacency within # number of words (in any order)
.ti	Title
.ab	Abstract
.hw	Heading word; usually includes subject headings and controlled vocabulary
.kf	Author keyword heading word (MEDLINE)
.kw	Author keyword field (Embase)
/di	Diagnosis subheading (MEDLINE, Embase)
.jn	Journal name
.jw	Journal word (MEDLINE)
.jx	Journal word (Embase)
.pt	Publication type
ppez	Ovid database code; Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to Present
oemezd	Ovid database code; Embase 1974 to present, updated daily

MULTI-DATABASE STRATEGY
#	Implementation Search Strategy
1	Human Papillomavirus DNA Tests/
2	DNA Probes, HPV/
3	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (test or assay* or genotyping or typing or detection or amplification)).ti,kf,kw.
4	((HPV* or hrHPV) adj3 (test or assay* or genotyping or typing or detection or amplification)).ab.
5	((Papillomavirus* or Papilloma Virus) adj5 (test or assay* or genotyping or typing or detection or amplification)).ab.
6	(((HPV* or hrHPV) adj3 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,kf,kw.
7	(((Papillomavirus* or Papilloma Virus) adj5 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,kf,kw.
8	Papillomavirus Infections/di
9	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (screen or triage* or triaging or reflex)).ti,kf,kw.
10	((HPV* or hrHPV) adj3 (screen or triage* or triaging or reflex)).ab.
11	((Papillomavirus* or Papilloma Virus) adj5 (screen or triage* or triaging or reflex)).ab.
12	Cervical Intraepithelial Neoplasia/
13	Uterine Cervical Neoplasms/
14	Uterine Cervical Dysplasia/
15	Atypical Squamous Cells of the Cervix/
16	Cervix Uteri/
17	Vaginal Smears/
18	Papanicolaou Test/
19	(cervical or cervix or cervixes or cervico* or pap or papanicolaou).ti,kf,kw.
20	((cervical or cervix or cervixes or cervico) adj3 (precancer or cancer* or neoplas* or dysplas* or dyskaryos* or tumor* or tumour* or malignanc* or carcinoma* or adenocarcinoma* or lesion* or squamous or small cell or large cell)).ti,ab,kf,kw.
21	(atypical glandular cell* or AGC or AGUS).ti,ab,kf,kw.
22	(CIN or CINII* or CIN2* or CINIII* or CIN3* or SIL or HSIL or LSIL or ASCUS or AS-CUS).ti,ab,kf,kw.
23	or/12-22
24	Mass Screening/
25	“Direct-To-Consumer Screening and Testing”/
26	Early Detection of Cancer/
27	Triage/
28	(screen* or triage* or triaging or reflex).ti,ab,kf,kw.
29	(detect* or test* or diagnos* or identify* or identifi* or predict* or cytology).ti,kf,kw.
30	or/24-29
31	23 and 30
32	((pap or papanicolaou or cervical or cervix or cervixes or cervico) adj2 (screen or triage* or triaging or smear* or test* or cytology)).ab.
33	or/1-11,31-32
34	Policy/ or Delivery of Health Care/ or Health Policy/ or Health Services Accessibility/
35	(implementation or implementer* or barrier* or facilitat* or enabler*).ti,ab,kf.
36	implementation science.jn.
37	(adopt* or sustainability or accept* or access* or appropriat* or feasibility or uptake).ti,ab,kf.
38	(training or trained or train or travel* or cultur* or socio* or social* or society or determinants or education* or communication or participation or wait time*).ti,ab,kf.
39	(geography or geographic or transportation or reimbursement or staff or staffing or workforce or workflow* or equipment or incentive*).ti,ab,kf.
40	(physician* adj2 (knowledge or perspective*)).ti,ab,kf.
41	Decision Support Techniques/ or (decision rule* or decision support or decision aid* or decision analys?s or decision model*).ti,ab,kf.
42	(policy or policies or health services or health care services or healthcare services).ti,ab,kf.
43	Laboratory Personnel/ or Laboratories/
44	(laboratory assistant* or laboratory scientist* or laboratory technician* or laboratory professional* or cytologist*).ti,ab,kf.
45	(referral* adj2 rate*).ti,ab,kf.
46	(screening adj2 rate*).ti,ab,kf.
47	(self-test* or self-sampl* or home-test*).ti,ab,kf.
48	(physician* adj2 visit*).ti,ab,kf.
49	or/34-48
50	33 and 49
51	50 use ppez
52	Human papillomavirus DNA test/
53	exp nucleic acid probe/ and (HPV* or hrHPV* or Papillomavirus* or Papilloma Virus*).ti,ab,kw,hw.
54	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (test or assay* or genotyping or typing or detection or amplification)).ti,kw.
55	((HPV* or hrHPV) adj3 (test or assay* or genotyping or typing or detection or amplification)).ab.
56	((Papillomavirus* or Papilloma Virus) adj5 (test or assay* or genotyping or typing or detection or amplification)).ab.
57	(((HPV* or hrHPV) adj3 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,kw.
58	(((Papillomavirus* or Papilloma Virus) adj5 (deoxyribonucleic or ribonucleic or nucleic or DNA or RNA or mRNA)) and (test or assay* or genotyping or typing or detection or amplification)).ti,ab,kw.
59	papillomavirus infection/di
60	((HPV* or hrHPV* or Papillomavirus* or Papilloma Virus) and (screen or triage* or triaging or reflex)).ti,kw.
61	((HPV* or hrHPV) adj3 (screen or triage* or triaging or reflex)).ab.
62	((Papillomavirus* or Papilloma Virus) adj5 (screen or triage* or triaging or reflex)).ab.
63	uterine cervix disease/
64	uterine cervix dysplasia/
65	squamous intraepithelial lesion of the cervix/
66	uterine cervix tumor/
67	uterine cervix cancer/
68	uterine cervix carcinoma/
69	uterine cervix cytology/
70	exp uterine cervix/
71	vagina smear/
72	Papanicolaou test/
73	(cervical or cervix or cervixes or cervico* or pap or papanicolaou).ti,kw.
74	((cervical or cervix or cervixes or cervico) adj5 (precancer or cancer* or neoplas* or dysplas* or dyskaryos* or tumor* or tumour* or malignanc* or carcinoma* or adenocarcinoma* or lesion* or squamous or small cell or large cell)).ti,ab,kw.
75	(atypical glandular cell* or AGC or AGUS).ti,ab,kw.
76	(CIN or CINII* or CIN2* or CINIII* or CIN3* or SIL or HSIL or LSIL or ASCUS or AS-CUS).ti,ab,kw.
77	or/63-76
78	screening/
79	mass screening/
80	cancer screening/
81	screening test/
82	DNA screening/
83	early cancer diagnosis/
84	(screen* or triage* or triaging or reflex).ti,ab,kw.
85	(detect* or test* or diagnos* or identify* or identifi* or predict* or cytology).ti,kw.
86	or/78-85
87	77 and 86
88	((pap or papanicolaou or cervical or cervix or cervixes or cervico) adj2 (screen or triage* or triaging or smear* or test* or cytology)).ab.
89	or/52-62,87-88
90	health care policy/ or policy/ or health care delivery/
91	(implementation or implementer* or barrier* or facilitat* or enabler*).ti,ab,kw.
92	(adopt* or sustainability or accept* or access* or appropriat* or feasibility or uptake).ti,ab,kw.
93	(training or trained or train or travel* or cultur* or socio* or social* or society or determinants or education* or communication or participation or wait time*).ti,ab,kw.
94	(geography or geographic or transportation or reimbursement or staff or staffing or workforce or workflow* or equipment or incentive*).ti,ab,kw.
95	(physician* adj2 (knowledge or perspective*)).ti,ab,kw.
96	(policy or policies or health services or health care services or healthcare services).ti,ab,kw.
97	Decision Making/ or (decision rule* or decision support or decision aid* or decision analys?s or decision model*).ti,ab,kw.
98	laboratory personnel/ or laboratory/
99	(laboratory assistant* or laboratory scientist* or laboratory technician* or laboratory professional* or cytologist*).ti,ab,kw.
100	(referral* adj2 rate*).ti,ab,kw.
101	(screening adj2 rate*).ti,ab,kw.
102	(self-test* or self-sampl* or home-test*).ti,ab,kw.
103	(physician* adj2 visit*).ti,ab,kw.
104	or/90-100
105	89 and 104
106	89 use oemezd
107	51 or 106
108	exp Canada/
109	(canadian* or canada* or british columbia* or alberta* or saskatchewan* or manitoba* or ontario* or quebec* or new brunswick* or prince edward island* or nova scotia* or labrador* or newfoundland* or nunavut* or northwest territor* or yukon* or toronto* or montreal* or vancouver* or ottawa* or calgary* or edmonton* or winnipeg* or first nation* or metis).ti,ab,kf,kw,hw.
110	(canadian* or canada* or british columbia* or alberta* or saskatchewan* or manitoba* or ontario* or quebec* or new brunswick* or prince edward island* or nova scotia* or labrador* or newfoundland* or nunavut* or northwest territor* or yukon* or toronto* or montreal* or vancouver* or ottawa* or calgary* or edmonton* or winnipeg* or first nation* or metis).jw,jx.
111	or/108-110
112	107 and 111
113	112 not conference abstract.pt.
114	limit 113 to yr=“2002 -Current”
115	limit 114 to (english or french)
116	remove duplicates from 115

OTHER DATABASES
PubMed	A limited PubMed search was performed to capture records not found in MEDLINE. Same MeSH, keywords, and limits used as per MEDLINE search, with appropriate syntax used.
CINAHL	Same keywords and limits used as per MEDLINE search. Syntax adjusted for EBSCO platform. MEDLINE records excluded.

Grey Literature

Dates for Search:

February/March, 2017

Keywords:

Included terms for HPV testing and cervical cancer screening.

Limits:

Publication years 2002-present

English or French language only

Relevant websites from the following sections of the CADTH grey literature checklist Grey Matters: a practical tool for searching health-related grey literature (https://www.cadth.ca/resources/finding-evidence/grey-matters) were searched:

health technology assessment agencies
health economics
clinical practice guidelines
clinical trials (ongoing)
databases (free)
Internet search
open access journals.

The copyright and other intellectual property rights in this document are owned by CADTH and its licensors. These rights are protected by the Canadian Copyright Act and other national and international laws and agreements. Users are permitted to make copies of this document for non-commercial purposes only, provided it is not modified when reproduced and appropriate credit is given to CADTH and its licensors.

Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

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Chao YS, Clark M, Carson E, et al. HPV Testing for Primary Cervical Cancer Screening: A Health Technology Assessment [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2019 Mar. (CADTH Optimal Use Report, No. 7.1b.) Appendix 1, Literature Search Strategy.
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HPV Testing for Primary Cervical Cancer Screening: A Health Technology Assessment [Internet].

Appendix 1Literature Search Strategy

Clinical Database Search

Patients’ Perspectives and Experience Database Search

Ethics Database Search

Implementation Database Search

Grey Literature

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