Feed and Compound Consumption in the Feed Studies of p-Toluenesulfonamide

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National Toxicology Program. NTP Technical Report on the Toxicity Studies of p-Toluenesulfonamide (CASRN 70-55-3) Administered in Feed to F344/N Rats, F344/NTac Rats, and B6C3F1/N Mice: Toxicity Report 88 [Internet]. Research Triangle Park (NC): National Toxicology Program; 2016 Aug.

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NTP Technical Report on the Toxicity Studies of p-Toluenesulfonamide (CASRN 70-55-3) Administered in Feed to F344/N Rats, F344/NTac Rats, and B6C3F1/N Mice: Toxicity Report 88 [Internet].

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Appendix GFeed and Compound Consumption in the Feed Studies of p-Toluenesulfonamide

Table G-1Feed and Compound Consumption by F344/N Rats in the Two-week Feed Study of p-Toluenesulfonamide

Week	0 ppm		750 ppm			1,500 ppm			3,000 ppm
Week	Feed^a (g/day)	Body Weight (g)	Feed (g/day)	Body Weight (g)	Dose^b (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)
Male
1	–	90	–	91	–	–	91	–	–	93	–
2	15.5	127	16.4	126	98	14.6	124	177	15.6	128	366
3	16.5	161	14.2	153	70	16.1	161	150	15.6	159	295
Female
1	–	90	–	89	–	–	87	–	–	88	–
2	12.2	108	11.9	110	81	12.1	108	168	11.7	103	340
3	10.5	126	11.9	128	70	11.8	125	142	11.6	121	288
						10,000 ppm			30,000 ppm
						Feed (g/day)	Body Weight (g)	Dose (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)
Male
1						–	91	–	–	89	–
2						12.9	116	1,110	8.3	92	2,698
3						14.8	147	1,005	12.8	114	3,369
Female
1						–	90	–	–	90	–
2						11.0	104	1,061	7.5	92	2,449
3						10.8	118	913	9.6	104	2,761

^a: Grams of feed consumed per animal per day.
^b: Milligrams of p-toluenesulfonamide consumed per kilogram body weight per day.

Table G-2Feed and Compound Consumption by Male F344/NTac Rats in the Three-month Feed Study of p-Toluenesulfonamide

Week	0 ppm		625 ppm			1,250 ppm			2,500 ppm
Week	Feed^a (g/day)	Body Weight (g)	Feed (g/day)	Body Weight (g)	Dose^b (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)
1	–	87	–	87	–	–	89	–	–	89	–
2	16.2	124	16.4	123	83	16.6	126	165	15.5	122	318
3	16.5	156	16.3	156	65	17.0	161	132	15.8	154	257
4	18.1	190	17.5	189	58	18.3	195	117	17.1	184	232
5	17.9	219	17.8	215	52	18.3	223	103	17.4	210	207
6	16.2	240	16.7	233	45	17.9	243	92	16.9	229	185
7	18.5	261	17.2	253	43	18.0	264	85	17.9	250	179
8	17.5	273	16.0	260	39	16.7	266	78	17.0	261	163
9	17.3	288	16.6	276	38	16.9	283	75	16.9	275	154
10	16.7	298	15.3	283	34	18.8	287	82	16.5	288	143
11	15.0	305	17.0	299	36	19.2	310	78	16.2	298	136
12	16.9	316	16.4	306	34	17.5	319	69	15.9	304	131
13	16.6	329	15.8	315	31	16.5	331	62	15.9	307	130
14	16.6	339	16.1	325	31	16.0	338	59	16.9	323	131
						5,000 ppm			10,000 ppm
						Feed (g/day)	Body Weight (g)	Dose (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)
1						–	87	–	–	87	–
2						14.1	115	615	13.2	112	1,182
3						15.4	145	532	14.2	141	1,009
4						16.7	175	478	15.5	168	922
5						17.1	202	422	30.2	195	1,553
6						17.2	223	386	16.6	213	780
7						17.4	242	360	16.8	235	715
8						17.8	252	353	15.9	246	646
9						16.2	263	308	16.0	261	614
10						13.3	269	247	16.0	274	584
11						17.1	287	298	16.4	287	572
12						16.5	295	279	15.8	293	540
13						16.3	311	262	16.0	307	522
14						16.7	320	261	15.9	315	505

^a: Grams of feed consumed per animal per day.
^b: Milligrams of p-toluenesulfonamide consumed per kilogram body weight per day.

Table G-3Feed and Compound Consumption by Female F344/NTac Rats in the Three-month Feed Study of p-Toluenesulfonamide

Week	0 ppm		625 ppm			1,250 ppm			2,500 ppm
Week	Feed^a (g/day)	Body Weight (g)	Feed (g/day)	Body Weight (g)	Dose^b (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)
1	–	83	–	86	–	–	85	–	–	84	–
2	12.1	105	12.8	106	76	13.0	106	154	12.3	105	294
3	12.1	122	12.5	122	64	12.3	123	125	12.3	120	257
4	12.4	136	12.7	136	59	12.2	135	113	12.4	134	232
5	12.1	149	12.5	148	53	11.9	146	102	12.2	145	211
6	11.8	156	12.0	154	49	12.0	153	98	12.0	154	195
7	12.1	164	12.3	163	47	11.6	160	90	11.6	156	185
8	11.8	169	11.3	167	42	11.2	164	85	11.6	164	177
9	11.4	175	11.3	172	41	11.4	172	83	11.7	171	171
10	11.1	177	11.3	176	40	10.4	173	75	11.1	173	161
11	11.1	182	11.5	181	40	11.0	175	79	11.6	179	162
12	10.5	186	11.1	186	37	11.1	184	75	10.9	182	150
13	10.4	189	10.6	187	36	10.5	185	71	10.8	185	146
14	10.3	190	10.8	190	36	10.2	187	68	10.3	187	138
						5,000 ppm			10,000 ppm
						Feed (g/day)	Body Weight (g)	Dose (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)
1						–	86	–	–	85	–
2						11.6	105	555	10.6	99	1,071
3						11.5	120	478	10.4	112	932
4						12.0	133	451	11.1	125	890
5						11.6	144	403	10.5	136	773
6						11.6	151	384	11.2	143	783
7						11.1	158	352	10.6	150	707
8						10.8	161	336	10.5	153	687
9						11.1	167	333	10.5	159	660
10						10.6	169	313	9.7	161	604
11						10.8	176	308	10.4	167	623
12						10.4	178	292	9.8	170	577
13						10.1	182	278	9.4	172	547
14						10.1	184	275	9.6	174	550

^a: Grams of feed consumed per animal per day.
^b: Milligrams of p-toluenesulfonamide consumed per kilogram body weight per day.

Table G-4Feed and Compound Consumption by Mice in the Two-week Feed Study of p-Toluenesulfonamide

Week	0 ppm		750 ppm			1,500 ppm			3,000 ppm
Week	Feed^a (g/day)	Body Weight (g)	Feed (g/day)	Body Weight (g)	Dose^b (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)
Male
1	–	22.1	–	22.5	–	–	22.4	–	–	22.7	–
2	5.1	23.3	5.0	23.4	160	4.1	23.4	263	5.8	23.0	756
3	4.6	24.6	4.4	24.7	134	5.2	23.9	326	5.3	24.8	641
Female
1	–	16.9	–	17.2	–	–	17.3	–	–	17.0	–
2	3.5	18.2	3.0	17.9	125	3.3	17.6	281	4.0	17.8	673
3	3.9	19.6	3.1	19.3	120	3.4	18.5	276	3.6	19.0	567
						10,000 ppm			30,000 ppm
						Feed (g/day)	Body Weight (g)	Dose (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)
Male
1						–	22.3	–	–	22.1	–
2						4.7	22.9	2,054	5.2	20.6	7,573
3						4.7	23.9	1,970	5.9	21.2	8,341
Female

1						–	17.4	–	–	16.9	–
2						5.1	17.3	2,951	3.0	16.1	5,590
3						3.7	19.1	1,941	3.7	16.6	6,679

^a: Grams of feed consumed per animal per day.
^b: Milligrams of p-toluenesulfonamide consumed per kilogram body weight per day.

Table G-5Feed and Compound Consumption by Male Mice in the Three-month Feed Study of p-Toluenesulfonamide

Week	0 ppm		625 ppm			1,250 ppm			2,500 ppm
Week	Feed^a (g/day)	Body Weight (g)	Feed (g/day)	Body Weight (g)	Dose^b (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)
1	–	22.2	–	22.2	–	–	22.7	–	–	22.7	–
2	4.3	22.8	5.8	22.7	160	5.8	23.2	312	4.7	23.0	511
3	4.6	23.5	6.3	23.3	169	5.0	24.4	256	4.9	23.0	533
4	4.4	24.3	4.9	23.9	128	4.2	25.2	208	4.4	24.9	442
5	4.4	25.3	5.1	25.5	125	5.7	26.2	272	5.1	25.6	497
6	5.6	26.6	6.3	26.5	149	6.0	27.3	275	5.4	26.6	508
7	5.6	26.7	5.5	26.6	129	5.6	27.7	253	5.1	27.0	472
8	5.3	27.8	4.6	27.4	105	4.4	28.4	194	5.1	27.6	462
9	4.6	28.6	5.2	28.7	113	4.9	29.4	208	4.7	28.9	407
10	5.0	29.6	4.7	29.2	101	5.4	30.2	223	5.0	29.8	420
11	4.3	30.4	4.5	30.0	94	4.8	31.2	193	4.4	30.3	364
12	4.6	30.9	4.6	30.5	94	4.2	31.0	169	4.5	30.9	364
13	4.8	32.0	4.7	31.2	94	4.8	31.9	188	4.4	31.3	351
14	4.3	32.1	4.4	31.8	86	4.1	32.4	158	4.5	31.7	355
						5,000 ppm			10,000 ppm
						Feed (g/day)	Body Weight (g)	Dose (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)
1						–	22.7	–	–	22.4	–
2						4.1	23.0	893	4.8	22.4	2,144
3						4.3	24.0	896	4.9	23.3	2,108
4						4.1	24.7	831	4.2	24.2	1,734
5						4.4	25.2	873	5.5	25.1	2,193
6						7.5	26.1	1,437	6.4	26.0	2,458
7						6.5	26.0	1,248	5.3	26.3	2,017
8						5.3	26.3	1,006	5.2	26.8	1,940
9						5.3	27.8	954	4.7	27.8	1,694
10						5.9	28.9	1,022	4.9	28.2	1,737
11						4.9	29.7	826	4.5	29.2	1,539
12						4.7	30.2	779	4.1	29.1	1,409
13						4.8	30.8	779	4.1	29.5	1,391
14						4.1	30.8	666	4.4	30.0	1,466

^a: Grams of feed consumed per animal per day.
^b: Milligrams of p-toluenesulfonamide consumed per kilogram body weight per day.

Table G-6Feed and Compound Consumption by Female Mice in the Three-month Feed Study of p-Toluenesulfonamide

Week	0 ppm		625 ppm			1,250 ppm			2,500 ppm
Week	Feed^a (g/day)	Body Weight (g)	Feed (g/day)	Body Weight (g)	Dose^b (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)
1	–	18.4	–	18.7	–	–	18.7	–	–	18.7	–
2	3.4	18.9	3.2	19.1	105	3.8	19.3	246	3.6	19.2	469
3	3.0	19.5	3.1	19.2	101	3.3	19.8	208	3.4	19.8	430
4	3.1	19.7	3.2	20.1	100	3.4	20.7	205	3.3	20.2	409
5	3.1	21.2	3.4	20.5	104	3.3	21.8	190	3.3	21.1	392
6	3.4	21.0	3.5	22.0	99	3.4	22.2	192	3.4	21.6	394
7	3.4	21.5	3.5	22.3	98	3.8	22.8	208	3.3	22.2	371
8	3.6	21.3	3.5	22.8	96	3.5	22.3	197	3.0	22.2	338
9	3.7	22.0	3.8	22.6	105	3.5	23.3	187	3.6	22.3	403
10	3.6	23.2	3.7	24.4	95	3.5	24.6	178	3.7	24.3	380
11	3.4	23.6	3.8	25.2	94	3.7	25.2	184	3.7	24.9	372
12	3.6	24.9	4.0	25.6	98	3.7	25.5	181	4.1	25.7	399
13	3.5	24.4	3.9	26.3	93	3.9	26.4	185	4.0	25.9	387
14	3.6	24.8	3.6	26.7	84	3.8	27.1	176	3.3	26.4	313
						5,000 ppm			10,000 ppm
						Feed (g/day)	Body Weight (g)	Dose (mg/kg)	Feed (g/day)	Body Weight (g)	Dose (mg/kg)
1						–	18.8	–	–	18.5	–
2						3.4	19.2	885	3.6	19.0	1,898
3						3.1	19.5	793	3.5	19.1	1,830
4						3.4	20.1	846	4.2	20.0	2,100
5						3.0	21.0	713	4.2	20.1	2,094
6						3.3	21.7	762	4.1	21.4	1,920
7						3.0	21.9	684	4.2	21.7	1,940
8						3.9	23.0	848	5.0	22.6	2,215
9						3.8	23.4	811	4.3	21.2	2,030
10						3.6	23.2	777	4.4	22.9	1,924
11						3.3	23.7	696	4.0	23.3	1,718
12						3.6	24.8	727	4.6	23.9	1,921
13						3.5	25.0	699	4.8	24.0	2,003
14						3.5	25.4	689	4.6	24.8	1,857

^a: Grams of feed consumed per animal per day.
^b: Milligrams of p-toluenesulfonamide consumed per kilogram body weight per day.

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National Toxicology Program. NTP Technical Report on the Toxicity Studies of p-Toluenesulfonamide (CASRN 70-55-3) Administered in Feed to F344/N Rats, F344/NTac Rats, and B6C3F1/N Mice: Toxicity Report 88 [Internet]. Research Triangle Park (NC): National Toxicology Program; 2016 Aug. Appendix G, Feed and Compound Consumption in the Feed Studies of p-Toluenesulfonamide.
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