Table E-1Mutagenicity of Trans-resveratrol in Bacterial Tester Strainsa

StrainConcentration (μg/plate)Without S9With 10% Rat S9
TA98
015 ± 143 ± 3
3313 ± 225 ± 2
10019 ± 133 ± 2
33319 ± 138 ± 1
1,00016 ± 231 ± 3
3,33314 ± 134 ± 3
Trial SummaryNegativeNegative
Positive Controlb97 ± 4594 ± 29
TA100
0126 ± 9147 ± 2
33149 ± 3139 ± 5
100141 ± 6148 ± 5
333137 ± 1136 ± 5
1,000133 ± 5108 ± 4
3,33351 ± 1474 ± 21
Trial SummaryNegativeNegative
Positive Controlc434 ± 21929 ± 43
TA102
0286 ± 14384 ± 15
34288 ± 4389 ± 18
102299 ± 8386 ± 12
340304 ± 11397 ± 19
1,019272 ± 29365 ± 43
3,333132 ± 17180 ± 21
Trial SummaryNegativeNegative
Positive Controld930 ± 641,310 ± 22
a

Studies performed at BioReliance. Data are presented as revertants/plate (mean ± standard error) from three plates; 0 μg/plate served as the solvent control.

b

The positive control in the absence of metabolic activation was 4-nitro-o-phenylenediamine (1.0 μg/plate); the positive control for metabolic activation was 2-aminoanthracene (0.4 μg/plate).

c

The positive control in the absence of metabolic activation was sodium azide (0.5 μg/plate); the positive control for metabolic activation was 2-aminoanthracene (0.75 μg/plate).

d

The positive control in the absence of metabolic activation was mitomycin C (75.0 μg/plate); the positive control for metabolic activation was sterigmatocystin (10.0 μg/plate).

From: Appendix E, Genetic Toxicology

Cover of NTP Technical Report on the Toxicity Studies of Trans-resveratrol (CASRN 501-36-0) Administered by Gavage for Two Weeks or Three Months to F344/NTac Rats, Wistar Han [Crl:WI(Han)] Rats, and B6C3F1/N Mice
NTP Technical Report on the Toxicity Studies of Trans-resveratrol (CASRN 501-36-0) Administered by Gavage for Two Weeks or Three Months to F344/NTac Rats, Wistar Han [Crl:WI(Han)] Rats, and B6C3F1/N Mice: Toxicity Report 102 [Internet].
National Toxicology Program.
Research Triangle Park (NC): National Toxicology Program; 2021 Dec.
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