NTP Genetically Modified Model Reports describe the toxicologic potential, including carcinogenic activity, of selected agents in laboratory animals that have been genetically modified.

Contents

• NTP Genetically Modified Model Report on the Toxicology and Carcinogenicity Studies of 3’-Azido-3’-Deoxythymidine (CASRN 30516-87-1) in Genetically Modified C3B6.129F1-Trp53 ^tm1Brd N12 Haploinsufficient Mice (In Utero and Postnatal Gavage Study): NTP GMM 14
  J.E.A. Leakey, W.T. Allaben, J.K. Dunnick, F.W. Lee, S.M. Lewis, P.C. Howard, C.C. Weis, D.D. Paine, S.M. Billedeau, B.R. Brown, J.P Freeman, J. Moody, L.K. Schoenbachler, P.H. Siitonen, S.J. Culp, J.M. Fowler, R.D. Smith, S. Appana, S.J. Baek, R.P. Felton, and B.T. Thorn. C.J. Cain, J.W. Carson, and A. Matson. K.A. Carroll and S.H. Green. P.W. Mellick, G.R. Olson, A.R. Warbritton, and L.P. Wiley. M.H. Hamlin, II, J.F. Hardisty, and R.A. Miller. J.F. Hardisty, J.M. Cullen, S.A. Elmore, D.E. Malarkey, P.W. Mellick, R.A. Miller, and G.R. Olson. P.C. Howard, W.T. Allaben, N.J. Walker, and J.R. Bucher. S.R. Gunnels, L.M. Harper, E.S. Rathman, and D.C. Serbus.
  Research Triangle Park (NC): National Toxicology Program; October 2013.
• NTP Genetically Modified Model Report on the Toxicology and Carcinogenicity Study of Mixtures of 3′-Azido-3′-Deoxythymidine (AZT), Lamivudine (3TC), and Nevirapine (NVP) (CASRNs 30516-87-1, 134678-17-4, 129618-40-2) in Genetically Modified C3B6.129F1-Trp53 ^tm1Brd N12 Haploinsufficient Mice (In Utero and Postnatal Gavage Study): NTP GMM 16
  J.E.A. Leakey, W.T. Allaben, J.K. Dunnick, S.M. Lewis, P.C. Howard, C.C. Weis, D.D. Paine, B.R. Brown, J.P. Freeman, T.M. Heinze, P.H. Siitonen, S.J. Culp, J.M. Fowler, R.D. Smith, R.P. Felton, and B.T. Thorn. C.J. Cain, J.W. Carson, and A. Matson. K.A. Carroll and S.H. Green. P.W. Mellick, G.R. Olson, A.R. Warbritton, and L.P. Wiley. M.H. Hamlin, II, E.T. Adams, and R.A. Miller. R.A. Miller, E.T. Adams, G.P. Flake, J.R. Latendresse, and G.R. Olson. P.C. Howard, W.T. Allaben, N.J. Walker, and J.R. Bucher. S.R. Gunnels, L.M. Harper, T.S. Kumpe, E.S. Rathman, and D.C. Serbus.
  Research Triangle Park (NC): National Toxicology Program; October 2013.
• NTP Genetically Modified Model Report on the Toxicology Study of Senna (CASRN 8013-11-4) in C57BL/6NTac Mice and Toxicology and Carcinogenesis Study of Senna in Genetically Modified C3B6.129F1/Tac-Trp53 ^tm1Brd N12 Haploinsufficient Mice (Feed Studies): NTP GMM 15
  I. Surh, J.K. Dunnick, A.E. Brix, J.B. Bishop, R.S. Chhabra, P.M. Foster, J.E. French, R.A. Herbert, M.J. Hooth, A.P. King-Herbert, G.E. Kissling, D.E. Malarkey, J.M. Sanders, C.S. Smith, G.S. Travlos, M.K. Vallant, N.J. Walker, and K.L. Witt. M.R. Hejtmancik and D. Vasconcelos. M.H. Hamlin, II, N. Allison, and J.C. Peckham. S. Brecher, S. Iyer, and V.S. Tharakan. W.G. Lieuallen, N. Allison, S.A. Elmore, M.J. Hoenerhoff, D.E. Malarkey, R.R. Maronpot, J.C. Peckham, and D. Vasconcelos. P.W. Crockett, L.J. Betz, and K.P. McGowan. S.R. Gunnels, L.M. Harper, T.S. Kumpe, J.I. Powers, and D.C. Serbus.
  Research Triangle Park (NC): National Toxicology Program; April 2012.
• NTP Genetically Modified Model Report on the Toxicology Studies of Allyl Bromide (CASRN 106-95-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Studies of Allyl Bromide in Genetically Modified [B6.129-Trp53 ^tm1Brd (N5) Haploinsufficient] Mice (Dermal and Gavage Studies): NTP GMM 07
  J.K. Dunnick, D.E. Malarkey, D.W. Bristol, J.R. Bucher, L.T. Burka, R.S. Chhabra, J.E. French, A.P. King-Herbert, G.E. Kissling, R.R. Maronpot, S.D. Peddada, C.S. Smith, G.S. Travlos, M.K. Vallant, and K.L. Witt. M.L. Wenk, C.E. Bentley, and L.L. Lanning. S. Brecher; P.W. Crockett, L.J. Betz, and K.P. McGowan. S.R. Gunnels, N.N. Buchanan, L.M. Harper, M.C. Joheim, P.C. Rathman, D.C. Serbus, and R.E. Shaver.
  Research Triangle Park (NC): National Toxicology Program; April 2008.
• NTP Genetically Modified Model Report on the Toxicology and Carcinogenesis Study of Phenolphthalein (CASRN 77-09-8) in Genetically Modified Haploinsufficient p16^Ink4a/p19^Arf Mice (Feed Study): NTP GMM 12
  J.K. Dunnick, D.E. Malarkey, D.W. Bristol, J.R. Bucher, L.T. Burka, R.S. Chhabra, J.E. French, R.A. Herbert, G.E. Kissling, A.P. King-Herbert, R.R. Maronpot, S.D. Peddada, C.S. Smith, G.S. Travlos, M.K. Vallant, and K.L. Witt. M.R. Hejtmancik and M.J. Ryan. M.H. Hamlin, II and R.A. Miller. S. Brecher; M.A. Hanes, S.A. Elmore, G.P. Flake, R.A. Herbert, D.E. Malarkey, R.A. Miller, and A. Nyska. P.W. Crockett, L.J. Betz, and K.P. McGowan. S.R. Gunnels, P.A. Gideon, B.F. Hall, L.M. Harper, M.C. Joheim, and D.C. Serbus.
  Research Triangle Park (NC): National Toxicology Program; December 2007.
• NTP Genetically Modified Model Report on the Toxicology and Carcinogenesis Study of Glycidol (CASRN 556-52-5) in Genetically Modified Haploinsufficient p16^ink4a/p19^Arf Mice (Gavage Study): NTP GMM 13
  J.K. Dunnick, D.E. Malarkey, D.W. Bristol, J.R. Bucher, L.T. Burka, R.S. Chhabra, J.E. French, R.A. Herbert, A.P. King-Herbert, G.E. Kissling, R.R. Maronpot, S.D. Peddada, C.S. Smith, G.S. Travlos, M.K. Vallant, and K.L. Witt. M.R. Hejtmancik and M.J. Ryan. M.H. Hamlin, II, K.J. Cimon, and J.C. Peckham. S. Brecher; W.G. Lieuallen and K.J. Cimon. S.A. Elmore, G.C. Hard, R.A. Herbert, P. Little, D.E. Malarkey, J.C. Peckham, and R.C. Sills. P.W. Crockett, L.J. Betz, and K.P. McGowan. S.R. Gunnels, L.M. Harper, M.C. Joheim, and D.C. Serbus.
  Research Triangle Park (NC): National Toxicology Program; November 2007.
• NTP Genetically Modified Model Report on the Toxicology and Carcinogenesis Study of Benzene (CASRN 71-43-2) in Genetically Modified Haploinsufficient p16^Ink4a/p19^Arf Mice (Gavage Study): NTP GMM 08
  J.K. Dunnick, D.E. Malarkey, D.W. Bristol, J.R. Bucher, L.T. Burka, R.S. Chhabra, J.E. French, R.A. Herbert, A.P. King-Herbert, G.E. Kissling, R.R. Maronpot, S.D. Peddada, C.S. Smith, G.S. Travlos, M.K. Vallant, and K.L. Witt. M.R. Hejtmancik and M.J. Ryan. M.H. Hamlin, II and J.C. Peckham. S. Brecher; A.W. Suttie and J.C. Peckham. P.W. Crockett, L.J. Betz, and K.P. McGowan. S.R. Gunnels, P.A. Gideon, B.F. Hall, L.M. Harper, and D.C. Serbus.
  Research Triangle Park (NC): National Toxicology Program; October 2007.
• NTP Genetically Modified Model Report on the Toxicology Studies of Dicyclohexylcarbodiimide (CASRN 538-75-0) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Trp53 ^tm1Brd (N5) Haploinsufficient] Mice (Dermal Studies): NTP GMM 09
  R.S. Chhabra, S.A. Elmore, D.W. Bristol, J.R. Bucher, L.T. Burka, J.E. French, A.P. King-Herbert, G.E. Kissling, D.E. Malarkey, R.R. Maronpot, J.C. Peckham, S.D. Peddada, C.S. Smith, G.S. Travlos, M.K. Vallant, and K.L. Witt. M.L. Wenk and J.M. Pletcher. M.L. Wenk and L.L. Lanning. M.H. Hamlin, II and E.T. Gaillard. S. Brecher; P.K. Hildebrandt, E.T. Gaillard, J.E. Leininger, J. Mahler, D.E. Malarkey, A. Radovsky, D. Wolfe, C.A. Picut, and J. Mahler. P.W. Crockett, L.J. Betz, and K.P. McGowan. S.R. Gunnels, B.F. Hall, L.M. Harper, and D.C. Serbus.
  Research Triangle Park (NC): National Toxicology Program; September 2007.
• NTP Genetically Modified Model Report on the Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53 ^tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies): NTP GMM 05
  G.A. Boorman, R.A. Herbert, D.W. Bristol, J.R. Bucher, L.T. Burka, R.S. Chhabra, J.E. French, A.P. King-Herbert, G.E. Kissling, D.E. Malarkey, R.R. Maronpot, S.D. Peddada, C.S. Smith, G.S. Travlos, M.K. Vallant, and K.L. Witt. M.R. Hejtmancik, J.D. Johnson, and M.J. Ryan. M.H. Hamlin, II and J.C. Peckham. S. Brecher; S.D. Rousselle, R.A. Herbert, G. Pearse, J.C. Peckham, and D.C. Wolf. P.W. Crockett, L.J. Betz, and K.P. McGowan. S.R. Gunnels, L.M. Harper, E.S. Rathman, P.C. Rathman, and D.C. Serbus.
  Research Triangle Park (NC): National Toxicology Program; May 2007.
• NTP Genetically Modified Model Report on the Toxicology Studies of Dichloroacetic Acid (CASRN 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53 ^tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies): NTP GMM 11
  G.A. Boorman, R.A. Herbert, D.W. Bristol, J.R. Bucher, L.T. Burka, R.S. Chhabra, J.E. French, J.R. Hailey, G.E. Kissling, A.P. King-Herbert, D.E. Malarkey, R.R. Maronpot, M.K. Vallant, S.D. Peddada, C.S. Smith, G.S. Travlos, and K.L. Witt. M.R. Hejtmancik and J.D. Toff, II. M.H. Hamlin, II, K.J. Cimon, P.C. Howroyd, and J.C. Peckham. S. Brecher; S.D. Rousselle, K.J. Cimon, R.A. Herbert, P.C. Howroyd, J. Mahler, G. Pearse, J.C. Peckham, and D.C. Wolf. P.W. Crockett, L.J. Betz, and K.P. McGowan. S.R. Gunnels, L.M. Harper, J.I. Powers, and D.C. Serbus.
  Research Triangle Park (NC): National Toxicology Program; April 2007.
• NTP Genetically Modified Model Report on the Toxicology Studies of Sodium Bromate (CASRN 7789-38-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Sodium Bromate in Genetically Modified [B6.129-Trp53 ^tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies): NTP GMM 06
  M.J. Hooth, J.C. Peckham, D.W. Bristol, J.R. Bucher, L.T. Burka, R.S. Chhabra, J.E. French, R.A. Herbert, A.P. King-Herbert, G.E. Kissling, D.E. Malarkey, R.R. Maronpot, S.D. Peddada, C.S. Smith, G.S. Travlos, M.K. Vallant, and K.L. Witt. M.R. Hejtmancik, J.D. Johnson, and M.J. Ryan. M.H. Hamlin, II, K.J. Cimon, P.C. Howroyd, and J.C. Peckham. S. Brecher; S. Rouselle, K.J. Cimon, R.A. Herbert, P.C. Howroyd, G. Pearse, J.C. Peckham, and D. Wolf. P.W. Crockett, L.J. Betz, and K.P. McGowan. S.R. Gunnels, P.H. Carver, B.F. Hall, L.M. Harper, and D.C. Serbus.
  Research Triangle Park (NC): National Toxicology Program; March 2007.
• NTP Genetically Modified Model Report on the Toxicology Study of Diispropylcarbodiimide (CASRN 693-13-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53 ^tm1Brd (N5) Haploinsufficient] Mice (Dermal Studies): NTP GMM 10
  R.S. Chhabra, G. Pearse, D.W. Bristol, J.R. Bucher, L.T. Burka, J.E. French, A.P. King-Herbert, G.E. Kissling, D.E. Malarkey, R.R. Maronpot, J.C. Peckham, S.D. Peddada, C.S. Smith, G.S. Travlos, M.K. Vallant, and K.L. Witt. M.L. Wenk and J.M. Pletcher. M.L. Wenk and L.L. Lanning. M.H. Hamlin, II and E.T. Gaillard. S. Brecher; P.K. Hildebrandt, E.T. Gaillard, J.E. Leininger, J. Mahler, D.E. Malarkey, A. Radovsky, D. Wolfe, C.A. Picut, and J. Mahler. P.W. Crockett, L.J. Betz, and K.P. McGowan. S.R. Gunnels, B.F. Hall, L.M. Harper, and D.C. Serbus.
  Research Triangle Park (NC): National Toxicology Program; March 2007.
• NTP Genetically Modified Model Report on the Toxicity Studies of Acesulfame Potassium (CASRN 55589-62-3) in FVB/N-TgN(v-Ha-ras)Led (Tg.AC) Hemizygous Mice and Carcinogenicity Studies of Acesulfame Potassium in B6.129-Trp53 ^tm1Brd (N5) Haploinsufficient Mice (Feed Studies): NTP GMM 02
  R.D. Irwin, D.E. Malarkey, D.W. Bristol, J.R. Bucher, J.E. French, J.R. Hailey, J.K. Haseman, R.A. Herbert, R.R. Maronpot, J.C. Peckham, J.H. Roycroft, C.S. Smith, G.S. Travlos, M.K. Vallant, and K.L. Witt. M.L. Wenk and L.L. Lanning. J.F. Hardisty and G. Willson. S. Brecher; C.A. Cummings and J. Mahler. P.W. Crockett, L.J. Betz, K.P. McGowan, and J.T. Scott. S.R. Gunnels, B.F. Hall, L.M. Harper, D.C. Serbus, and R.A. Willis.
  Research Triangle Park (NC): National Toxicology Program; October 2005.
• NTP Genetically Modified Model Report on the Toxicology Studies of Aspartame (CASRN 22839-47-0) in Genetically Modified (FVB Tg.AC Hemizygous) and B6.129-Cdkn2a^tm1Rdp (N2) Deficient Mice and Carcinogenicity Studies of Aspartame in Genetically Modified [B6.129-Trp53 ^tm1Brd (N5) Haploinsufficient] Mice (Feed Studies): NTP GMM 01
  J.R. Bucher, D.W. Bristol, J.E. French, J.R. Hailey, J.K. Haseman, R.A. Herbert, D.E. Malarkey, R.R. Maronpot, J.C. Peckham, J.H. Roycroft, C.S. Smith, G.S. Travlos, M.K. Vallant, and K.L. Witt. M.L. Wenk and L.L. Lanning. J.F. Hardisty and C.C. Shackelford. S. Brecher; P. Long, D. Dixon, G.P. Flake, R.A. Herbert, P.B. Little, A. Nyska, and C.C. Shackelford. P.W. Crockett, L.J. Betz, K.P. McGowan, and J.T. Scott. S.R. Gunnels, P.H. Carver, K.K. Coker, B.F. Hall, L.M. Harper, E.S. Rathman, D.C. Serbus, and R.A. Willis.
  Research Triangle Park (NC): National Toxicology Program; October 2005.
• NTP Genetically Modified Model Report on the Toxicology Studies of Pentaerythritol Triacrylate (Technical Grade) (CASRN 3524-68-3) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies): NTP GMM 04
  R.S. Chhabra, J. Mahler, D.W. Bristol, J.R. Bucher, J.E. French, J.R. Hailey, J.K. Haseman, R.A. Herbert, R.R. Maronpot, S.D. Peddada, G.N. Rao, C.S. Smith, G.S. Travlos, M.K. Vallant, and K.L. Witt. M.R. Hejtmancik, J.D. Toft, II, and J.T. Yarrington. J.F. Hardisty and J.C. Peckham. S. Brecher; P.W. Crockett, L.J. Betz, W. Jones, K.P. McGowan, and J.T. Scott. P.B. Little, J. Mahler, G.A. Parker, J.R. Hailey, R.A. Herbert, J. Mahler, R.R. Maronpot, A. Nyska, G. Pearse, and J.C. Peckham. S.R. Gunnels, P.A. Gideon, L.M. Harper, E.S. Paal, and D.C. Serbus.
  Research Triangle Park (NC): National Toxicology Program; October 2005.
• NTP Genetically Modified Model Report on the Toxicology Studies of Trimethylolpropane Triacrylate (Technical Grade) (CASRN 15625-89-5) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies): NTP GMM 03
  R.S. Chhabra, J. Mahler, D.W. Bristol, J.R. Bucher, J.E. French, J.R. Hailey, J.K. Haseman, R.A. Herbert, R.R. Maronpot, S.D. Peddada, G.N. Rao, C.S. Smith, G.S. Travlos, M.K. Vallant, and K.L. Witt. M.R. Hejtmancik, D.M. Sells, and J.D. Toft, II. J.F. Hardisty and J.C. Peckham. P.W. Crockett, L.J. Betz, W. Jones, K.P. McGowan, and J.T. Scott. S. Brecher; P.B. Little, J. Mahler, G.A. Parker, J.R. Hailey, R.A. Herbert, J. Mahler, R.R. Maronpot, A. Nyska, G. Pearse, and J.C. Peckham. S.R. Gunnels, P.A. Gideon, L.M. Harper, E.S. Paal, and D.C. Serbus.
  Research Triangle Park (NC): National Toxicology Program; October 2005.