Table A18Summary of the Incidence of Nonneoplastic Lesions in Female Heterozygous F1 p53+/− Mice in the 45-Week In Utero/Postnatal Gavage Stop-Study of AZTa

0/0 mg/kg240/40 mg/kg
Disposition Summary
Animals initially in study2626
Survivors
 Died last week of study13
 Terminal kill2523
Animals examined microscopically2626
Alimentary System
Intestine large, cecum(25)(26)
 Hyperplasia, lymphoid3 (12%)
Liver(25)(26)
 Basophilic focus1 (4%)
 Infiltration cellular, lymphocyte2 (8%)1 (4%)
 Inflammation, chronic active2 (8%)
 Tension lipidosis3 (12%)4 (15%)
 Vacuolization cytoplasmic12 (48%)6 (23%)
Salivary glands(25)(26)
 Infiltration cellular, lymphocyte15 (60%)12 (46%)
Cardiovascular System
Heart(25)(26)
Endocrine System
Adrenal cortex(26)(26)
 Subcapsular, hyperplasia23 (88%)24 (92%)
Thyroid gland(26)(26)
 Degeneration1 (4%)
 Ectopic thymus2 (8%)1 (4%)
General Body System
None
Genital System
Ovary(26)(26)
 Cyst4 (15%)1 (4%)
Uterus(26)(26)
 Infiltration cellular, polymorphonuclear1 (4%)
 Endometrium, hyperplasia, cystic4 (15%)3 (12%)
 Lumen, dilatation16 (62%)13 (50%)
Vagina(26)(25)
Hematopoietic System
Bone marrow(25)(26)
Lymph node(0)(2)
 Renal, hyperplasia, lymphoid1 (50%)
Lymph node, mandibular(25)(25)
 Hyperplasia, lymphoid1 (4%)
Lymph node, mesenteric(25)(26)
 Hyperplasia, lymphoid4 (16%)3 (12%)
Spleen(26)(26)
 Hematopoietic cell proliferation2 (8%)2 (8%)
 Hyperplasia, lymphoid6 (23%)6 (23%)
Thymus(25)(25)
 Cyst, multiple1 (4%)
 Hyperplasia, lymphoid1 (4%)3 (12%)
Integumentary System
Mammary gland(26)(26)
Musculoskeletal System
None
Nervous System
Brain, brain stem(26)(26)
Brain, cerebellum(26)(26)
Brain, cerebrum(26)(26)
 Mineralization2 (8%)4 (15%)
Respiratory System
Lung(26)(26)
 Infiltration cellular, lymphocyte1 (4%)
 Inflammation, chronic active1 (4%)
Special Senses System
Harderian gland(25)(26)
Urinary System
Kidney(25)(26)
 Infiltration cellular, lymphocyte9 (36%)5 (19%)
Urinary bladder(25)(26)
 Infiltration cellular, lymphocyte2 (8%)3 (12%)
 Lumen, dilatation1 (4%)
a

Number of animals examined microscopically at the site and the number of animals with lesion

From: APPENDIX A, SUMMARY OF LESIONS IN HETEROZYGOUS F1 p53+/− MICE IN THE IN UTERO/POSTNATAL GAVAGE STUDIES OF AZT

Cover of NTP Genetically Modified Model Report on the Toxicology and Carcinogenicity Studies of 3’-Azido-3’-Deoxythymidine (CASRN 30516-87-1) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice (In Utero and Postnatal Gavage Study)
NTP Genetically Modified Model Report on the Toxicology and Carcinogenicity Studies of 3’-Azido-3’-Deoxythymidine (CASRN 30516-87-1) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice (In Utero and Postnatal Gavage Study): NTP GMM 14 [Internet].
Leakey JEA, Allaben WT, Dunnick JK, et al.
Research Triangle Park (NC): National Toxicology Program; 2013 Oct.
Copyright Notice

This is a work of the US government and distributed under the terms of the Public Domain

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.