Table A15Summary of the Incidence of Nonneoplastic Lesions in Male Heterozygous F1 p53+/− Mice in the 45-Week In Utero/Postnatal Gavage Stop-Study of AZTa

0/0 mg/kg240/40 mg/kg
Disposition Summary
Animals initially in study2425
Early deaths
 Natural death1
Survivors
 Died last week of study12
 Terminal kill2322
Animals examined microscopically2425
Alimentary System
Intestine large, cecum(24)(24)
 Hyperplasia, lymphoid3 (13%)1 (4%)
Intestine large, rectum(24)(24)
 Degeneration, cystic1 (4%)
Liver(24)(25)
 Cytomegaly18 (75%)14 (56%)
 Eosinophilic focus1 (4%)
 Inflammation, chronic active1 (4%)1 (4%)
 Necrosis2 (8%)1 (4%)
 Tension lipidosis3 (13%)2 (8%)
 Vacuolization cytoplasmic23 (96%)18 (72%)
Pancreas(23)(25)
 Cytoplasmic alteration1 (4%)
Salivary glands(24)(25)
 Infiltration cellular, lymphocyte8 (33%)8 (32%)
Cardiovascular System
Blood vessel(24)(24)
Heart(24)(25)
Endocrine System
Adrenal cortex(24)(25)
 Hypertrophy1 (4%)
 Subcapsular, hyperplasia7 (29%)7 (28%)
Islets, pancreatic(23)(25)
 Hyperplasia1 (4%)2 (8%)
Thyroid gland(24)(24)
 Cyst1 (4%)
 Ectopic thymus1 (4%)
General Body System
Tissue NOS(0)(1)
Genital System
Epididymis(24)(24)
 Hypospermia1 (4%)
 Serosa, inflammation, chronic active1 (4%)
 Serosa, necrosis1 (4%)
Preputial gland(24)(24)
 Abscess1 (4%)
 Degeneration1 (4%)
 Duct, dilatation1 (4%)
Prostate(24)(25)
 Infiltration cellular, lymphocyte1 (4%)1 (4%)
 Epithelium, hyperplasia1 (4%)
Seminal vesicle(24)(25)
 Serosa, inflammation, chronic active1 (4%)
Testes(24)(24)
 Spermatocele1 (4%)
 Interstitial cell, hyperplasia2 (8%)4 (17%)
 Seminiferous tubule, degeneration2 (8%)2 (8%)
Hematopoietic System
Bone marrow(24)(25)
 Myeloid cell, hyperplasia2 (8%)
Lymph node, mesenteric(24)(24)
 Hyperplasia, lymphoid15 (63%)12 (50%)
Spleen(24)(24)
 Depletion lymphoid1 (4%)
 Hematopoietic cell proliferation2 (8%)3 (13%)
 Hyperplasia, lymphoid5 (21%)7 (29%)
Thymus(23)(22)
 Degeneration1 (4%)
 Hyperplasia, lymphoid1 (5%)
 Necrosis1 (5%)
Integumentary System
Skin(24)(25)
Musculoskeletal System
None
Nervous System
Brain, cerebrum(24)(25)
 Mineralization6 (25%)3 (12%)
Respiratory System
Lung(24)(25)
 Foreign body1 (4%)
 Infiltration cellular, polymorphonuclear1 (4%)
 Bronchiole, epithelium, hyperplasia1 (4%)
Nose(24)(25)
 Foreign body1 (4%)
 Inflammation, suppurative1 (4%)
Special Senses System
Harderian gland(24)(25)
Urinary System
Kidney(24)(25)
 Infiltration cellular, lymphocyte6 (25%)6 (24%)
 Mineralization1 (4%)
 Capsule, inflammation, chronic active1 (4%)
 Pelvis, dilatation1 (4%)
 Renal tubule, regeneration2 (8%)3 (12%)
Urinary bladder(24)(24)
 Infiltration cellular, lymphocyte1 (4%)
a

Number of animals examined microscopically at the site and the number of animals with lesion

From: APPENDIX A, SUMMARY OF LESIONS IN HETEROZYGOUS F1 p53+/− MICE IN THE IN UTERO/POSTNATAL GAVAGE STUDIES OF AZT

Cover of NTP Genetically Modified Model Report on the Toxicology and Carcinogenicity Studies of 3’-Azido-3’-Deoxythymidine (CASRN 30516-87-1) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice (In Utero and Postnatal Gavage Study)
NTP Genetically Modified Model Report on the Toxicology and Carcinogenicity Studies of 3’-Azido-3’-Deoxythymidine (CASRN 30516-87-1) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice (In Utero and Postnatal Gavage Study): NTP GMM 14 [Internet].
Leakey JEA, Allaben WT, Dunnick JK, et al.
Research Triangle Park (NC): National Toxicology Program; 2013 Oct.
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