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National Toxicology Program. NTP Developmental and Reproductive Toxicity Technical Report on the Modified One-Generation Study of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats with Prenatal and Reproductive Performance Assessments in F1 Offspring: DART Report 05 [Internet]. Research Triangle Park (NC): National Toxicology Program; 2022 Jun.
NTP Developmental and Reproductive Toxicity Technical Report on the Modified One-Generation Study of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats with Prenatal and Reproductive Performance Assessments in F1 Offspring: DART Report 05 [Internet].
Show detailsAdditional information on ingredients, vitamins, and minerals in the 5K96 rat diet can be found online.121
Table B-1Nutrient Composition of 5K96 Rat Ration
| Nutrient | Mean ± Standard Deviation | Range | Number of Samples |
|---|---|---|---|
| Protein (% by Weight) | 21.04 ± 0.6188 | 19.9–21.7 | 7 |
| Crude Fat (% by Weight) | 4.23 ± 0.1604 | 4.0–4.4 | 7 |
| Crude Fiber (% by Weight) | 3.21 ± 0.2260 | 2.95–3.63 | 7 |
| Ash (% by Weight) | 6.73 ± 0.3696 | 6.13–7.20 | 7 |
| Vitamins | |||
| Vitamin A (IU/kg) | 18,714 ± 2,918 | 14,800–22,600 | 7 |
| Thiamine (ppm)a | 16.86 ± 1.753 | 14.2–19.8 | 7 |
| Minerals | |||
| Calcium (%) | 1.273 ± 0.1316 | 1.18–1.56 | 7 |
| Phosphorus (%) | 0.963 ± 0.0668 | 0.886–1.09 | 7 |
- a
As hydrochloride.
Table B-2Contaminant Levels in 5K96 Rat Ration
| Contaminant | Mean ± Standard Deviation | Range | Number of Samples |
|---|---|---|---|
| Arsenic (ppm) | 0.3366 ± 0.0501 | 0.267–0.398 | 7 |
| Cadmium (ppm) | 0.041 ± 0.0041 | 0.0327–0.0457 | 7 |
| Lead (ppm) | 0.2393 ± 0.0122 | 0.224–0.263 | 7 |
| Mercury (ppm) | 0.0106 ± 0.0010 | 0.01–0.0126 | 7 |
| Selenium (ppm) | 0.4451 ± 0.0421 | 0.404–0.53 | 7 |
| Aflatoxins (ppb)a | <2.0 | – | 7 |
| Nitrate Nitrogen (ppm)b | 14.73 ± 10.95 | 1.69–24.6 | 7 |
| Nitrite Nitrogen (ppm)a,b | <1.0 | – | 7 |
| BHA (ppm)c | 0.743 ± 0.4392 | 0.1–1.0 | 7 |
| BHT (ppm)c | 0.793 ± 0.4903 | 0.1–1.35 | 7 |
| Aerobic Plate Count (CFU/g)d | 1,275 ± 2,712 | 10–6,800 | 7 |
| Coliform (MPN/g) | <3.0 | – | 7 |
| Escherichia coli (MPN/g) | <10.0 | – | 7 |
| Enterobacteriaceae (MPN/g) | <3.0 | – | 7 |
| Total Nitrosamines (ppb)e | 9.9 ± 8.4 | 0–24.8 | 7 |
| N-N-dimethylamine (ppb)e | 6.6 ± 6.9 | 0–20.3 | 7 |
| N-N-pyrrolidine (ppb)e | 3.3 ± 2.5 | 0–7.5 | 7 |
| Pesticides (ppm) | |||
| α-BHCa | – | – | 7 |
| β-BHCa | – | – | 7 |
| γ-BHCa | – | – | 7 |
| δ-BHCa | – | – | 7 |
| Heptachlora | – | – | 7 |
| Aldrina | – | – | 7 |
| Heptachlor Epoxidea | – | – | 7 |
| DDEa | – | – | 7 |
| DDDa | – | – | 7 |
| DDTa | – | – | 7 |
| HCBa | – | – | 7 |
| Mirexa | – | – | 7 |
| Methoxychlora | – | – | 7 |
| Dieldrina | – | – | 7 |
| Endrina | – | – | 7 |
| Telodrina | – | – | 7 |
| Chlordanea | – | – | 7 |
| Toxaphenea | – | – | 7 |
| Estimated PCBsa | – | – | 7 |
| Ronnela | – | – | 7 |
| Ethiona | – | – | 7 |
| Trithiona | – | – | 7 |
| Diazinona | – | – | 7 |
| Methyl Chlorpyrifos | 0 ± 0.02 | 0.02 | 7 |
| Methyl Parathiona | – | – | 7 |
| Ethyl Parathiona | – | – | 7 |
| Malathion | 0 ± 0.02 | 0.02 | 7 |
| Endosulfan Ia | – | – | 7 |
| Endosulfan IIa | – | – | 7 |
| Endosulfane Sulfatea | – | – | 7 |
All samples were irradiated. BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming units; MPN = most probable number; BHC = hexachlorocyclohexane or benzene hexachloride; DDE = dichlorodiphenyldichloroethylene; DDD = dichlorodiphenyldichloroethane; DDT = dichlorodiphenyltrichloroethane; HCB = hexachlorobenzene; PCB = polychlorinated biphenyl.
- a
All values were below the detection limit. The detection limit is given as the mean.
- b
Sources of contamination include alfalfa, grains, and fish meal.
- c
Sources of contamination include soy oil and fish meal.
- d
Preirradiation values given.
- e
All values were corrected for percent recovery.
- Ingredients, Nutrient Composition, and Contaminant Levels in 5K96 Rat Ration - N...Ingredients, Nutrient Composition, and Contaminant Levels in 5K96 Rat Ration - NTP Developmental and Reproductive Toxicity Technical Report on the Modified One-Generation Study of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats with Prenatal and Reproductive Performance Assessments in F1 Offspring
- PREDICTED: Sus scrofa leucine rich repeat containing 72 (LRRC72), mRNAPREDICTED: Sus scrofa leucine rich repeat containing 72 (LRRC72), mRNAgi|1191912314|ref|XM_021063959.1|Nucleotide
- PREDICTED: Sus scrofa serine/arginine repetitive matrix protein 2-like (LOC11025...PREDICTED: Sus scrofa serine/arginine repetitive matrix protein 2-like (LOC110255568), mRNAgi|1191912335|ref|XM_021063970.1|Nucleotide
- PREDICTED: Sus scrofa translation initiation factor IF-2-like (LOC106504991), mR...PREDICTED: Sus scrofa translation initiation factor IF-2-like (LOC106504991), mRNAgi|1191912324|ref|XM_013979822.2|Nucleotide
- Discussion - NTP Developmental and Reproductive Toxicity Technical Report on the...Discussion - NTP Developmental and Reproductive Toxicity Technical Report on the Modified One-Generation Study of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats with Prenatal and Reproductive Performance Assessments in F1 Offspring
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