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Cover of Drug Class Review: Cyclo-oxygenase (COX)-2 Inhibitors and Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Drug Class Review: Cyclo-oxygenase (COX)-2 Inhibitors and Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Final Report Update 3

Drug Class Reviews

, MD, , MD, MPH, , MS, , MLS, and , BS.

Author Information and Affiliations
Portland (OR): Oregon Health & Science University; .

Non-steroidal anti-inflammatory drugs (NSAIDs) reduce pain and inflammation by blocking cyclo-oxygenases (COX), enzymes that are needed to produce prostaglandins. Most NSAIDs block two different cyclo-oxygenases, called COX-1 and COX-2. COX-2, found in joint and muscle tissue, contributes to pain and inflammation. Many NSAIDs also block COX-1, which may contribute to development of ulcers and gastrointestinal bleeding depending on the magnitude of blockade. More recently, some NSAIDs have also been associated with an increased risk of serious cardiovascular events, such as myocardial infarction. The purpose of this review is to compare the efficacy, effectiveness, and harms of NSAIDs.

Contents

The funding source, the Center for Evidence-based Policy, is supported by 17 organizations, including 15 state Medicaid programs. These organizations selected the topic and had input into the Key Questions for this review. The content and conclusions of the review are entirely determined by the Evidence-based Practice Center researchers. The authors of this report have no financial interest in any company that makes or distributes the products reviewed in this report.

Suggested citation:

Chou R, Helfand M, Peterson K, Dana T. (2004). Drug Class Review of Cyclo-oxygenase (COX)-2 Inhibitors and Non-steroidal Anti-inflammatory Drugs (NSAIDS). http://www.ohsu.edu/drugeffectiveness

The purpose of this report is to make available information regarding the comparative effectiveness and safety profiles of different drugs within pharmaceutical classes. Reports are not usage guidelines, nor should they be read as an endorsement of, or recommendation for, any particular drug, use or approach. Oregon Health & Science University does not recommend or endorse any guideline or recommendation developed by users of these reports.

Copyright © 2006, Oregon Health & Science University, Portland, Oregon.
Bookshelf ID: NBK10620PMID: 20496448

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