This Evidence Report contains information on 8 reviews relating to the investigation, management and follow-up of glioma. The Evidence Report is split into 3 sections:

• investigation of suspected glioma, which contains 2 reviews

  • imaging for suspected glioma
  • use of molecular markers to determine prognosis or guide treatment for glioma
• management of glioma, which contains 5 reviews

  • initial surgery for suspected low-grade glioma
  • further management of newly diagnosed low-grade glioma
  • management of newly diagnosed high-grade glioma following surgery or if surgery is not possible (or has been declined)
  • management of recurrent high-grade glioma (recurrent grade III and grade IV glioma)
  • techniques for resection of glioma
• follow-up for glioma, which contains 1 review

  • follow-up for glioma.

Contents

• Investigation of suspected glioma
  • Imaging for suspected glioma
  • Use of molecular markers to determine prognosis or guide treatment for glioma
• Management of glioma
  • Initial surgery for suspected low-grade glioma
  • Further management of newly diagnosed low-grade glioma
  • Management of newly diagnosed high-grade glioma following surgery or if surgery is not possible (or has been declined)
  • Management of recurrent high-grade glioma (recurrent grade III and grade IV glioma)
  • Techniques for resection of glioma
• Follow-up for glioma
  • Follow-up for glioma
• Appendices
  • Appendix A. Review protocols
  • Appendix B. Literature search strategies
  • Appendix C. Clinical evidence study selection
  • Appendix D. Clinical evidence tables
  • Appendix E. Forest plots
  • Appendix F. GRADE tables
  • Appendix G. Economic evidence study selection
  • Appendix H. Economic evidence tables
  • Appendix I. Health economic profiles
  • Appendix J. Health economic analysis
  • Appendix K. Excluded studies
  • Appendix L. Research recommendations

Final

developed by the National Guideline Alliance, hosted by the Royal College of Obstetricians and Gynaecologists

Disclaimer: The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or service users. The recommendations in this guideline are not mandatory and the guideline does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.

Local commissioners and/or providers have a responsibility to enable the guideline to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with compliance with those duties.

NICE guidelines cover health and care in England. Decisions on how they apply in other UK countries are made by ministers in the Welsh Government, Scottish Government, and Northern Ireland Executive. All NICE guidance is subject to regular review and may be updated or withdrawn.