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Contents
- Introduction
- 1. Simple Analgesics:Paracetamol
- 1.1. Review question 1: What is the clinical and cost effectiveness of IV paracetamol compared to oral paracetamol given post operatively in managing acute postoperative pain?
- 1.2. PICO table
- 1.3. Clinical evidence
- 1.4. Economic evidence
- 1.5. Evidence statements
- 1.6. Review question 2: What is the clinical and cost effectiveness of IV paracetamol given intraoperatively in managing acute post-operative pain?
- 1.7. PICO table
- 1.8. Clinical evidence
- 1.9. Economic evidence
- 1.10. Evidence statements
- 2. Simple anlagesics: Non-steroidal anti-inflammatory drugs (NSAIDs)
- 2.1. Methods approach
- 2.2. Review question 1: What is the clinical and cost effectiveness of NSAIDs for managing acute postoperative pain?
- 2.3. PICO table
- 2.4. Clinical evidence
- 2.5. Economic evidence
- 2.6. Evidence statements
- 2.7. Review question 2: Which is the most clinical and cost effective intervention within the class of NSAIDs for managing acute postoperative pain?
- 2.8. PICO table
- 2.9. Clinical evidence
- 2.10. Economic evidence
- 2.11. Evidence statements
- 3. Opioid
- 3.1. Review question 1: What is the clinical and cost effectiveness of IV opioid compared to oral opioid given post operatively in managing acute post-operative pain?
- 3.2. PICO table
- 3.3. Clinical evidence
- 3.4. Economic evidence
- Evidence statements
- 3.5. Review question 2: What is the most clinically and cost effective opioid administration strategy?
- 3.6. PICO table
- 3.7. Clinical evidence
- 3.8. Economic evidence
- 3.9. Evidence statements
- 4. Intravenous ketamine
- 5. Neuropathic nerve stabilisers
- 6. The committee’s discussion of the evidene
- References
Final
Evidence reviews underpinning recommendations 1.6.1 to 1.6.13 in the NICE guideline
This evidence review was developed by the National Guideline Centre
Disclaimer: The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or service users. The recommendations in this guideline are not mandatory and the guideline does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and, where appropriate, their carer or guardian.
Local commissioners and providers have a responsibility to enable the guideline to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with compliance with those duties.
NICE guidelines cover health and care in England. Decisions on how they apply in other UK countries are made by ministers in the Welsh Government, Scottish Government, and Northern Ireland Executive. All NICE guidance is subject to regular review and may be updated or withdrawn.
- Evidence reviews for managing acute postoperative painEvidence reviews for managing acute postoperative pain
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