Interventions for Children and Young People – Risk of Bias Table

National Collaborating Centre for Mental Health (UK)

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National Collaborating Centre for Mental Health (UK). Bipolar Disorder: The NICE Guideline on the Assessment and Management of Bipolar Disorder in Adults, Children and Young People in Primary and Secondary Care. London: The British Psychological Society and The Royal College of Psychiatrists; 2014 Sep. (NICE Clinical Guidelines, No. 185.)

See 2018 Partial Update

April 2018: Footnotes and cautions have been added and amended to link to the MHRA's latest advice and resources on sodium valproate. Sodium valproate must not be used in pregnancy, and only used in girls and women when there is no alternative and a pregnancy prevention plan is in place. This is because of the risk of malformations and developmental abnormalities in the baby. November 2017: Footnotes for some recommendations were updated with current UK marketing authorisations and MHRA advice. Links to other guidelines have also been updated. Some research recommendations have been stood down. See these changes in the short version of the guideline.

April 2018: Footnotes and cautions have been added and amended to link to the MHRA's latest advice and resources on sodium valproate. Sodium valproate must not be used in pregnancy, and only used in girls and women when there is no alternative and a pregnancy prevention plan is in place. This is because of the risk of malformations and developmental abnormalities in the baby. November 2017: Footnotes for some recommendations were updated with current UK marketing authorisations and MHRA advice. Links to other guidelines have also been updated. Some research recommendations have been stood down. See these changes in the short version of the guideline.

Bipolar Disorder: The NICE Guideline on the Assessment and Management of Bipolar Disorder in Adults, Children and Young People in Primary and Secondary Care.

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APPENDIX 28Interventions for Children and Young People – Risk of Bias Table

Study ID	Random sequence generation (selection bias)	Allocation concealment (selection bias)	Blinding of participants and personnel	Blinding of outcome assessment (detection bias)	Incomplete outcome data (attrition bias)	Selective reporting (reporting bias)	Other
ASTRAZENECA2011b	+	?	+	+	+	+	+
CUMMINGS2007	+	+	-	-	+	-	+
DELBELLO2002	+	+	+	?	-	-	+
DELBELLO2005	+	?	+	?	-	?	+
DELBELLO2006	?	?	+	+	+	?	+
DELBELLO2009	+	+	+	+	-	+	+
ELILILLY2011	+	?	+	+	+	-	+
ELILILLY2013	+	?	+	+	-	-	+
FINDLING2005	?	?	+	?	-	-	?
FINDLING2009	+	?	+	?	+	+	?
FINDLING2012	+	?	+	?	+	-	?
HAAS2009	+	?	+	?	+	-	+
HEBRANI2009	+	?	-	+	?	-	+
MIKLOWITZ2008	+	+	-	+	-	-	+
PATHAK2013	+	+	+	?	+	+	+
PAVULURI2010	+	?	+	+	-	?	+
PAVULURI2012	+	?	+	?	+	-	+
PFIZER2011	+	+	+	?	-	+	-
TOHEN2007	+	?	+	?	-	+	+
TRAMONTINA2009	+	+	+	+	+	+	?
WAGNER2009	+	?	+	?	+	-	+

All rights reserved. No part of this guideline may be reprinted or reproduced or utilised in any form or by any electronic, mechanical, or other means, now known or hereafter invented, or in any information storage or retrieval system, without permission in writing from the National Collaborating Centre for Mental Health. Enquiries in this regard should be directed to the Centre Administrator: ku.ca.hcyspcr@nimdAHMCCN

Bookshelf ID: NBK545956

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National Collaborating Centre for Mental Health (UK). Bipolar Disorder: The NICE Guideline on the Assessment and Management of Bipolar Disorder in Adults, Children and Young People in Primary and Secondary Care. London: The British Psychological Society and The Royal College of Psychiatrists; 2014 Sep. (NICE Clinical Guidelines, No. 185.) APPENDIX 28, Interventions for Children and Young People – Risk of Bias Table.
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