Interventions for Acute Depression – Risk of Bias Tables

National Collaborating Centre for Mental Health (UK)

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National Collaborating Centre for Mental Health (UK). Bipolar Disorder: The NICE Guideline on the Assessment and Management of Bipolar Disorder in Adults, Children and Young People in Primary and Secondary Care. London: The British Psychological Society and The Royal College of Psychiatrists; 2014 Sep. (NICE Clinical Guidelines, No. 185.)

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April 2018: Footnotes and cautions have been added and amended to link to the MHRA's latest advice and resources on sodium valproate. Sodium valproate must not be used in pregnancy, and only used in girls and women when there is no alternative and a pregnancy prevention plan is in place. This is because of the risk of malformations and developmental abnormalities in the baby. November 2017: Footnotes for some recommendations were updated with current UK marketing authorisations and MHRA advice. Links to other guidelines have also been updated. Some research recommendations have been stood down. See these changes in the short version of the guideline.

April 2018: Footnotes and cautions have been added and amended to link to the MHRA's latest advice and resources on sodium valproate. Sodium valproate must not be used in pregnancy, and only used in girls and women when there is no alternative and a pregnancy prevention plan is in place. This is because of the risk of malformations and developmental abnormalities in the baby. November 2017: Footnotes for some recommendations were updated with current UK marketing authorisations and MHRA advice. Links to other guidelines have also been updated. Some research recommendations have been stood down. See these changes in the short version of the guideline.

Bipolar Disorder: The NICE Guideline on the Assessment and Management of Bipolar Disorder in Adults, Children and Young People in Primary and Secondary Care.

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APPENDIX 17Interventions for Acute Depression – Risk of Bias Tables

1.1.1. Pharmacological interventions

Study ID	Random sequence generation (selection bias)	Allocation concealment (selection bias)	Blinding of participants and personnel	Blinding of outcome assessment (detection bias)	Incomplete outcome data (attrition bias)	Selective reporting (reporting bias)	Other
BRISTOLMYERSSQUIB2006	+	?	+	?	-	-	+
BRISTOLMYERSSQUIB2007	+	?	+	?	-	-	+
BROWN2006	+	?	+	?	-	-	+
CALABRESE1999	+	?	+	?	-	-	+
CALABRESE2005	+	+	+	?	+	?	+
CALABRESE2008a	+	?	+	?	-	?	+
CALABRESE2008b	+	?	+	?	-	?	+
CALABRESE2008c	+	?	+	-	-	+	+
CALABRESE2008d	+	?	+	?	+	+	+
DAVIS2005	?	?	+	?	-	-	+
GHAEMI2007	?	?	+	?	+	-	+
MCELROY2010	+	+	+	+	-	-	+
MUZINA2011	?	?	-	+	-	?	+
NEMEROFF2001	?	?	+	?	-	?	+
PFIZER2009a	?	?	?	+	-	-	+
PFIZER2009b	?	?	?	?	-	-	+
POST2006	?	?	-	?	-	?	+
QUANTE2010	+	?	+	+	-	-	+
SILVERSTONE2001	+	+	+	?	-	?	+
SUNOVION2012a	?	?	+	?	+	-	+
SUNOVION2012b	?	+	+	?	-	-	+
SUPPES2010	+	+	+	?	-	+	+
THASE2006	+	?	+	?	-	-	+
TOHEN2003	+	+	+	+	-	?	+
TOHEN2012	+	?	+	?	-	+	+
VANDERLOOS2009	+	?	+	+	+	+	+
YOUNG2010	+	+	+	+	-	+	+

1.1.2. Nutritional interventions

Study ID	Random sequence generation (selection bias)	Allocation concealment (selection bias)	Blinding of participants and personnel	Blinding of outcome assessment (detection bias)	Incomplete outcome data (attrition bias)	Selective reporting (reporting bias)	Other
KECK2006b	+	+	+	?	-	-	+

1.1.3. Physical interventions

Study ID	Random sequence generation (selection bias)	Allocation concealment (selection bias)	Blinding of participants and personnel	Blinding of outcome assessment (detection bias)	Incomplete outcome data (attrition bias)	Selective reporting (reporting bias)	Other
DENNEHY2009b	+	?	-	+	-	-	+
DENNEHY2009a	+	?	-	+	-	-	-
DAUPHINAIS2012	+	?	-	+	-	?	+
WU2009	+	?	-	-	+	-	+
NAHAS2003	+	?	?	+	+	?	+

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Bookshelf ID: NBK545969

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National Collaborating Centre for Mental Health (UK). Bipolar Disorder: The NICE Guideline on the Assessment and Management of Bipolar Disorder in Adults, Children and Young People in Primary and Secondary Care. London: The British Psychological Society and The Royal College of Psychiatrists; 2014 Sep. (NICE Clinical Guidelines, No. 185.) APPENDIX 17, Interventions for Acute Depression – Risk of Bias Tables.
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