Appendix 7Review questions
For people who misuse alcohol, what are their experiences of having problems with alcohol, of access to services and of treatment?
For families and carers of people who misuse alcohol, what are their experiences of caring for people with an alcohol problem and what support is available for families and carers?
In adults with alcohol misuse, what is the clinical efficacy, cost effectiveness, and safety of, and patient satisfaction associated with different systems for the organisation of care?
What are the most effective (a) diagnostic and (b) assessment tools for alcohol dependence and harmful alcohol use?
What are the most effective ways of monitoring clinical progress in alcohol dependence and harmful alcohol use?
To answer questions 4 and 5, what are the advantages, disadvantages, and clinical utility of:
the structure of the overall clinical assessment
biological measures
psychological/behavioural measures
neuropsychiatric measures (including cognitive impairment)
physical assessment?
In adults in planned alcohol withdrawal, what is the clinical efficacy, cost effectiveness, safety of, and patient satisfaction associated with:
preparatory work before withdrawal
different drug regimens
the setting (that is, community, residential or inpatient)?
In adults in planned alcohol withdrawal what factors influence the choice of setting in terms of clinical and cost effectiveness including:
In adults with harmful or dependent alcohol use what are the preferred structures for and components of community-based and residential specialist alcohol services to promote long-term clinical and cost-effective outcomes?
For people with alcohol dependence or who are harmful drinkers, is psychological treatment x when compared with y, more clinically and cost effective and does this depend on:
presence of comorbidities
subtypes (matching effects)
therapist-related factors (quality, therapeutic alliance, competence, training, and so on).
What are the most effective (a) diagnostic and (b) assessment tools for alcohol dependence and harmful alcohol use in children and young people (aged 10–18 years)?
What are the most effective ways of monitoring clinical progress in alcohol dependence and harmful alcohol use in children and young people (aged 10–18 years)?
For children and young people with alcohol dependence or harmful alcohol use is treatment x when compared with y more clinically and cost effective and does this depend on the presence of comorbidities?
For people with alcohol dependence or harmful alcohol use, what pharmacological interventions are more clinically and cost effective? In addition:
What are the impacts of severity and comorbities on outcomes?
When should pharmacological treatments be initiated and for what duration should they be prescribed?
