This report is the result of a two-phase study as explained in the preface. The first phase of the work of the IOM Committee to Study Medication Development and Research at NIDA resulted in the desk-top published report, Development of Anti-Addiction Medications: Issues for the Government and Private Sector. That preliminary report was published in March 1994 and was available through the IOM Division of Biobehavioral Sciences and Mental Disorders. It was the intent of the Institute of Medicine to publish the report through the National Academy Press after both phases of the study had been completed; this report incorporates both phases of the committee's work. The chapters in this, the final report, have been reorganized from the preliminary report as follows:

• A preface to the final edition
• An executive summary
• Chapters 1–3, unchanged
• Chapters 4–6, new text from the second phase of the committee's work
• Chapter 7, the text from Chapter 4 of the preliminary report (originally entitled "The Interaction of Federal Regulatory Agencies and the Private Sector")
• Chapter 8, new text from the second phase of the committee's work
• Chapter 9, incorporates Chapter 5 of the preliminary report with additional text and recommendations

Minor changes were made in Chapters 1–3 and 7 to update prevalence statistics, add cross-references, and incorporate the erratum to the preliminary report.