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National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Health Sciences Policy; Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse; Phillips JK, Ford MA, Bonnie RJ, editors. Pain Management and the Opioid Epidemic: Balancing Societal and Individual Benefits and Risks of Prescription Opioid Use. Washington (DC): National Academies Press (US); 2017 Jul 13.

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Pain Management and the Opioid Epidemic: Balancing Societal and Individual Benefits and Risks of Prescription Opioid Use.

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Appendix CExisting Data Sources on Opioid Use, Misuse, Overdose, and Other Harms

DataSourceNumeratorsDescriptionTimingStrengthsLimitations
National Forensic Laboratory Information System (NFLIS)U.S. Drug Enforcement Administration (DEA)Drug cases investigated by the DEA at compound level (diversion)Chemistry on drugs seized by law enforcement is analyzed by state, county, and volunteer forensic labs. Available for states, participating localities, and nationally.MonthlyUniform data collection across sites and over time. Detects new/emerging drugs.Captures only mentions, not quantity seized. Not an appropriate surrogate for misuse. Decisions regarding enforcement and prosecution may influence which drugs are seized/tested. Significant lag in identifying new synthetic drugs because reference standards may not exist.
Poison control callsState poison control centers, National Poison Data System (NPDS)Poison control calls related to “intentional exposures” (includes abuse, misuse, and suspected suicidal) or “intentional abuse exposures”Number of exposure calls by drug/substance at state and national levels.MonthlyAbility to detect new/emerging drugs in real time. Product- and drug-specific information.NPDS analyses must be requested and purchased; available 12 months after year ends; specific poison center data may be available in real time (depends on center). Possible misclassification of drug involved and reason for exposure. May underrepresent most severe cases of misuse.
Drug treatment admissions (e.g., Treatment Episode Data Set [TEDS])State and local drug treatment agenciesLifetime nonmedical opioid, heroin users; past-year and past-month heroin use, any nonmedical opioid use (not product-specific)Admissions to publicly funded treatment programs and opioid substitution programs by primary, secondary, and tertiary drug, route of administration, demographics. Available at local, state, and national levels.Annual, semiannual, or monthly depending on sourceData collection is relatively uniform across states.May be influenced by funding streams and referral sources (e.g., criminal justice diversion or emphasis on certain drugs). Publicly available TEDS data lag 1–2 years. Limited differentiation of opioid products. Not nationally representative.
Arrestee Drug Abuse Monitoring (ADAM) ProgramOffice of National Drug Control PolicySurvey/urine screen of recently arrested individuals (diversion)Urinalysis results (marijuana, cocaine, opiates, methamphetamine) and self-reported drug use.AnnualUniform data collection across sites; sample includes individuals generally not captured in other datasets (e.g., drug treatment).Male arrestees only, limited to five sites in 2012. No longer fully operational. Not an appropriate surrogate for misuse.
System to Retrieve Information from Drug Evidence (STRIDE)DEAStreet drug price by geographic area; street drug purity by geographic areaDrug exhibits sent to the DEA laboratories. Provides national data on purity and weight of each sample by month seized. Totals annual seizure weights by drug.AnnualOnly source of data on illicit drug purity and price. Complete datasets can be obtained via Freedom of Information Act (FOIA) request and analyzed.Strongly influenced by enforcement activities; not representative.
Uniform Crime Report (UCR)Federal Bureau of InvestigationArrests due to possession or trafficking of heroin and other opiatesUCR Part II contains annual summary of drug-related arrests (possession, sale). Reported by each law enforcement unit at the local level.AnnualSystem has been in operation more than 30 years; is being updated to allow online analysis.Strongly influenced by enforcement priorities. Only four categories of drugs. No ability to do any data analysis other than summaries.
National Survey on Drug Use and Health (NSDUH)Substance Abuse and Mental Health Services Administration (SAMHSA)Lifetime nonmedical opioid, heroin users; first-time nonmedical opioid use, heroin initiates; past-year and past-month heroin use, nonmedical opioid use by therapeutic drug class; Diagnostic and Statistical Manual of Mental Disorders, fourth edition, diagnosed abuse or dependenceSelf-reported drug use and abuse/dependence among respondents aged *12. Results available at national level and for some metropolitan statistical areas (MSAs) and substate areas.AnnualLongitudinal data collection supports analysis of changes over time. Data can be analyzed online.Household survey excludes institutionalized and unhoused individuals.
Youth Risk Behavior Surveillance System (YRBSS)U.S. Centers for Disease Control and Prevention (CDC)Youth rates of nonmedical use of prescription opioidsNational school-based survey of self-reported drug use. Includes results at state (n = 47) and local (n = 22) levels.Every 2 yearsRepresentative/weighted sample for United States and some states/localities. Longitudinal data collection supports analysis of changes over time.Limited to youth attending school.
Monitoring the Future (MTF)University of MichiganMisuse rates among middle school, high school, college students and young adultsNationally representative survey of self-reported drug use among 8th, 10th, 12th graders.AnnualLongitudinal data collection supports analysis of changes over time.Limited to youth attending school. Not site-specific. Asks about only two prescription opioid products; the rest are considered “narcotics other than heroin.”
Automation of Reports and Consolidated Orders System (ARCOS)DEAAmount of manufactured controlled substance circulating through legal means, by compoundMeasure of prescription drug supply based on mandatory reporting for Schedule I and II controlled substances and selected Schedule III and IV substances from manufacture to sale. Data for each substance reported by quantity (e.g., mg, dosage unit) and 3-digit zip code.AnnualComprehensive inventory of all legal drug sources. Can be analyzed longitudinally down to zip code level by individual substance, formula (e.g., extended-release).Cannot discern between licit and illicit drug use. Data must be procured through FOIA request.
Drug mortalityLocal medical examiners/coroners, state vital records, National Center for Health Statistics nationwide data; SAMHSA's Drug Abuse Warning Network (DAWN-ME) (ended 2011)Counts of drug-related mortality by compound, some by International Classification of Diseases (ICD) code; for DAWN-ME: mortality data (only for 13 states)Cause of death and toxicology, drug poisoning deaths, and drug-induced deaths. DAWN-ME captured agent-level data.Annual, although preliminary reports are available at local level soonerData can be analyzed online through CDC WONDER. Data available by state.Local medical examiner data may not include deaths where private physician was in attendance. Drug use may or may not be based on autopsy reports—depends on state law. State data have 1–2 year time lag; national NCHS is complete in 2–3 years. Cause of death determined by ICD category.
Emergency department (ED) visits and/or hospital discharges for drug-related causesCDC (SAMHSA's Drug Abuse Warning Network [DAWN-ED] ended 2011; also the Nationwide Emergency Department Sample [NEDS], which conducted a 20 percent sample of EDs, was discontinued)Unclear, but documentation suggests these will be ICD code–defined ED visits (e.g., unintentional poisoning); for DAWN-ED: misuse/abuse-related ED visitsNational Hospital Care Survey is a new survey that will provide data on health care delivery in inpatient, outpatient, and EDs, as well as other ambulatory settings. Will include data on drug-related care episodes. Previously, DAWN-ED collected data using retrospective records review at EDs selected through longitudinal probability sampling. DAWN-ED captured agent-level data on exposures and clinical drug-involved consequences.New system is not functionalOne of few measures of drug-related morbidity. Unclear at what level of geographic specificity these data will be reported.New system is not yet operational. Longitudinal data from DAWN will not be compatible with new system. Unclear if agent-level data will be available, as this is a function of hospital toxicological testing procedures.
HIV/hepatitis C virus (HCV) dataState and local health departmentsNew cases of HIV related to injection drug use (IDU); new cases of HCV related to IDUNew infections attributed to IDU, IDU by men who have sex with men (MSM), and heterosexual modes of transmission.HIV reports usually annual, sometime semiannual or monthly; HCV reports less frequentComprehensive record of individuals who test positive for HIV and risk factors. Reported at county, state, and national levels.Risk group (e.g., IDU, MSM-IDU, heterosexual) is self-reported. Levels of HIV—and especially HCV—testing vary across sites.
Trends in trafficking reportsDEA Field DivisionsStreet price of drugs; availability and sources of drugEach Field Division reports price data, availability, sources, and trafficking by drug.SemiannualExtensive data on supply side. Unclear geographic specificity. Unclear whether product- and/or compound-specific.DEA redacts sensitive data prior to release. Possible sampling biases, possible selection biases.
Proprietary surveillance systemResearched Abuse, Diversion and Addiction-Related Surveillance System (RADARS)Lifetime nonmedical opioid, heroin use; first-time nonmedical opioid use, heroin initiates; past-year and past-month heroin use, nonmedical opioid use by product; measures of diversion; street price of opioid productsDrug diversion, poison center, opioid treatment, impaired health care worker, Survey of Key Informants, college survey, StreetRx (streetrx​.com for street drug price) programs.Near real timeProduct and substance with composition- and formulation-specific differentiation. Exposure among certain high-risk groups can be identified (e.g., impaired health care workers). Multifaceted data collection effort. Geographically identified data.Must be requested and purchased. Possible sampling biases, possible information biases. Not nationally representative.
Proprietary surveillance systemNational Addictions Vigilance Intervention and Prevention Program (NAVIPPRO)Lifetime nonmedical opioid, heroin use; first-time nonmedical opioid use, heroin initiates; past-year and past-month heroin use; nonmedical opioid use by product; route of administration; lifetime and past-year nonfatal opioid overdose; source of opioidsAddiction Severity Index-Multimedia Version (ASI-MV) Connect includes assessments of adults on drug use and for treatment need (intake, criminal justice, drug courts, Temporary Assistance for Needy Families) at 3-digit zip code level. Web Informed Services (WIS) quantifies endorsement of drugs among drug-use forums and discussion boards. Comprehensive Health Assessment for Teens assesses teenagers and young adults on drug use and for treatment need at 3-digit zip code level.Near real timeProduct and substance with composition- and formulation-specific differentiation. Multifaceted data collection effort. Geographically identified data. Exposure among important high-risk groups can be identified (e.g., pregnant women, sexual minorities). Geographically identified data.Must be requested and purchased. Sampling bias possible; not a probability sample. Recall bias possible. Not nationally representative.
Copyright 2017 by the National Academy of Sciences. All rights reserved.
Bookshelf ID: NBK458657

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