This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the National Academies' Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the process.

We wish to thank the following individuals for their review of this report:

• Kenneth Berns, University of Florida
• Aaron Darling, University of Technology, Sydney, Australia
• Sean Eddy, HHMI Janelia Farm Research Campus
• Jens Kuhn, Integrated Research Facility, Fort Detrick, National Institutes of Health
• Ian Lipkin, Columbia University
• Stephen Morse, Columbia University
• Karen Nelson, J. Craig Venter Institute
• Tom Slezak, Lawrence Livermore National Laboratory
• Tim Trevan, International Council for the Life Sciences
• David Walt, Tufts University

Although the reviewers listed above have provided many constructive comments and suggestions, they were not asked to endorse the committee's conclusions, nor did they see the final draft of the report before its release. The review of this report was overseen by Ronald S. Brookmeyer, University of California, Los Angeles, and Ronald M. Atlas, University of Louisville. Appointed by the National Academies, they were responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the authoring committee and the institution.