Thimerosal Content in Licensed Vaccines

Institute of Medicine (US) Immunization Safety Review
                    Committee

CThimerosal Content in Licensed Vaccines

Publication Details

(Adapted from FDA, 2003, 2004)

TABLE C-1

Mercury Content from Thimerosal in the Routinely Recommended Pediatric Vaccines in the United States, April 2004.

TABLE C-2

Mercury Content from Thimerosal in the Currently Licensed Vaccines That Are Recommended for Some Children in the United States, April 2004.

TABLE C-3

Mercury Content from Thimerosal in Other Licensed Vaccines in the United States, April 2004.

Publication Details

Copyright

Publisher

National Academies Press (US), Washington (DC)

NLM Citation

Institute of Medicine (US) Immunization Safety Review Committee. Immunization Safety Review: Vaccines and Autism. Washington (DC): National Academies Press (US); 2004. C, Thimerosal Content in Licensed Vaccines.

TABLE C-1Mercury Content from Thimerosal in the Routinely Recommended Pediatric Vaccines¹ in the United States, April 2004

Vaccine	Brand Name	Manufacturer	Hg [μg/dose]
DTaP (Diphtheria and tetanus toxoids and acellular pertussis)	Tripedia	Aventis Pasteur, Inc.	≤0.3
	Infanrix	Glaxo-SmithKline	0
	Daptacel	Aventis Pasteur, Ltd	0
Td¹(Tetanus and diphtheria toxoids)	None	Aventis Pasteur, Inc.	25
	Decavac	Aventis Pasteur, Inc.	= 0.3
	None	Aventis Pasteur, Ltd	0
	None	Mass Public Health	8.3
DTaP-Hib (Diphtheria and tetanus toxoids with acellular pertussis combined with Haemophilus influenzae type b)	TriHIBit²	Aventis Pasteur	≤0.3
Hib (Haemophilus influenzae type b)	ActHIB/OmniHib	Aventis Pasteur, SA	0
	HibTITER (Single dose)	Wyeth-Lederle	0
	PedvaxHIB liquid	Merck	0
Hib/HepB (Haemophilus influenzae type b combined with Hepatitis B )	COMVAX	Merck	0
Hep B (Hepatitis B) (pediatric formulation)	Engerix B	Glaxo-SmithKline	<0.5
Hep B (Hepatitis B) (pediatric formulation)	Recombivax HB	Merck	0
Influenza	Fluzone³	Aventis Pasteur, Inc.	12.5
	Fluzone	Aventis Pasteur, Inc.	≤0.5ug/
	(Preservative Free)		0.25mL dose
Pneumococcal	Prevnar (pneumoconjugate)	Wyeth	0
IPV (Inactivated polio vaccine)	IPOL	Aventis Pasteur, SA	0
IPV (Inactivated polio vaccine)	Poliovax	Aventis Pasteur, Ltd.	0
MMR (Measles, mumps, and rubella)	MMR-II	Merck	0
Varicella	Varivax	Merck	0

1: Licensed for persons 7 years of age and older.

2: For use in children 15 to 18 months of age.

3: Influenza vaccine is recommended for children 6-23 months of age. MMWR (2004) 52:1-4; MMWR (2004) 53:1-3.

TABLE C-2 Mercury Content from Thimerosal in the Currently Licensed Vaccines That Are Recommended for Some Children in the United States, April 2004

Vaccine	Brand Name	Manufacturer	Hg [μg/dose]
DT (Diphtheria and tetanus toxoids)	All Products	Aventis Pasteur, Inc. (single dose)	0.3
		Aventis Pasteur, Inc. (multi-dose)	25
		Aventis Pasteur, Ltd^*	25
TT (Tetanus Toxoid)	All Products	Aventis Pasteur, Inc.	25
Pneumococcal Polysaccharide	Pneumovax 23	Merck	0
Hepatitis A	Havrix	Glaxo-SmithKline	0
Hepatitis A	Vaqta	Merck	0
Influenza	Fluzone¹	Aventis Pasteur, Inc.	25
	Fluzone (Preservative free)	Aventis Pasteur, Inc.	≤1 μg/0.5 mL dose or ≤0.5 μg/ 0.25 mL dose
	Fluvirin	Evans	25
	Fluvirin	Evans	<1 μg
Influenza, Live	FluMist	MedImmune	0

*: Not available in the United States.

1: Children under 3 years of age received half of a vaccine dose (0.25 mL or 12.5 μg mercury/dose).

TABLE C-3Mercury Content from Thimerosal in Other Licensed Vaccines in the United States, April 2004

Vaccine	Brand Name	Manufacturer	Hg [μg/dose]
Anthrax	BioThrax	BioPort Corporation	0
Smallpox	Dryvax	Wyeth	0
BCG*		Organon Tecknika	0
BCG*	Mycobax	Aventis Pasteur, Ltd	0
Hepatitis A-Hepatitis B	Twinrix	Glaxo-SmithKline	<1 μg
Hepatitis B	Engerix B (adult formulation)	Glaxo-SmithKline	< 0.5
	Recombivax HB (adult formulation)	Merck	25
	Recombivax HB (adult formulation)	Merck	0
Lyme^*	LYMErix	Glaxo-SmithKline	0
Meningococcal¹	Menomune A, C, AC and A/C/Y/W-135	Aventis Pasteur, Inc. (multidose)	25
Meningococcal¹		Single dose	0
Rabies	IMOVAX	Aventis Pasteur SA	0
Rabies	Rabavert	Chiron Behring	0
Typhoid Fever	Typhim Vi	Aventis Pasteur SA	0
Typhoid Fever	Vivotif Berna	Berna Biotech, Ltd.	0
Yellow Fever	YF-VAX	Aventis Pasteur, Inc.	0
Japanese Encephalitis Vaccine	JE-VAX	Aventis Pasteur, Inc.	35

*: Not available in the United States.

1: Menomune A/C/Y/W-135, a thimerosal-containing vaccine, is not indicated for infants and children younger than 2 years of age except as short-term protection of infants 3 months and older against Group A. (Physician's Desk Reference, 2001).

CThimerosal Content in Licensed Vaccines

TABLE C-1

TABLE C-2

TABLE C-3

Publication Details

Copyright

Publisher

NLM Citation

TABLE C-1Mercury Content from Thimerosal in the Routinely Recommended Pediatric Vaccines1 in the United States, April 2004

TABLE C-2 Mercury Content from Thimerosal in the Currently Licensed Vaccines That Are Recommended for Some Children in the United States, April 2004

TABLE C-3Mercury Content from Thimerosal in Other Licensed Vaccines in the United States, April 2004

TABLE C-1Mercury Content from Thimerosal in the Routinely Recommended Pediatric Vaccines¹ in the United States, April 2004