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Institute of Medicine (US) Board on Health Promotion and Disease Prevention. Scientific and Policy Considerations in Developing Smallpox Vaccination Options: A Workshop Report. Washington (DC): National Academies Press (US); 2002.

Cover of Scientific and Policy Considerations in Developing Smallpox Vaccination Options

Scientific and Policy Considerations in Developing Smallpox Vaccination Options: A Workshop Report.

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EPILOGUE

A summary of the June 15, 2002 IOM meeting was presented at the June 19–20, 2002 meeting of the Advisory Committee on Immunization Practices. The ACIP made its recommendations (below) on June 20th. These recommendations are currently under consideration by CDC and the Department of Health and Human Services.

Draft Supplemental Recommendations of the ACIP Use of Smallpox (Vaccinia) Vaccine, June 2002

Draft approved by ACIP on June 20, 2002 (SOURCE: http://www.cdc.gov/nip/smallpox/supp_recs.htm [accessed August 2002])

Pre-Release Vaccination of the General Population

Under current circumstances, with no confirmed smallpox, and the risk of an attack assessed as low, vaccination of the general population is not recommended, as the potential benefits of vaccination do not outweigh the risks of vaccine complications.

Recommendations regarding pre-outbreak smallpox vaccination are being made on the basis of an assessment that considers the risks of disease and the benefits and risks of vaccination. The live smallpox (vaccinia) vaccine virus can be transmitted from person to person. In addition to sometimes causing adverse reactions in vaccinated persons, the vaccine virus can cause adverse reactions in the contacts of vaccinated persons. It is assumed that the risk of serious adverse events with currently available vaccines would be similar to those previously observed and could be higher today due to the increased prevalence of persons with altered immune systems.

Pre-Release Vaccination of Selected Groups to Enhance Smallpox Response Readiness

Smallpox Response Teams

Smallpox vaccination is recommended for persons pre-designated by the appropriate bioterrorism and public health authorities to conduct investigation and follow-up of initial smallpox cases that would necessitate direct patient contact.

To enhance public health preparedness and response for smallpox control, specific teams at the federal, state and local level should be established to investigate and facilitate the diagnostic work-up of the initial suspect case(s) of smallpox and initiate control measures. These Smallpox Response Teams might include persons designated as medical team leader, public health advisor, medical epidemiologists, disease investigators, diagnostic laboratory scientist, nurses, personnel who would administer smallpox vaccines, and security/law enforcement personnel. Such teams may also include medical personnel who would assist in the evaluation of suspected smallpox cases.

The ACIP recommends that each state and territory establish and maintain at least one Smallpox Response Team. Considerations for additional teams should take into account population and geographic considerations and should be developed in accordance with federal, state, and local bioterrorism plans.

Designated Smallpox Healthcare Personnel at Designated Hospitals

Smallpox vaccination is recommended for selected personnel in facilities pre-designated to serve as referral centers to provide care for the initial cases of smallpox. These facilities would be pre-designated by the appropriate bioterrorism and public health authorities, and personnel within these facilities would be designated by the hospital.

As outlined in the CDC Interim Smallpox Response Plan and Guidelines state bioterrorism response plans should designate initial smallpox isolation and care facilities (e.g., type C facilities). In turn, these facilities should pre-designate individuals who would care for the initial smallpox cases. To staff augmented medical response capabilities, additional personnel should be identified and trained to care for smallpox patients.

Implementation of Recommendations

The ACIP recognizes that the implementation of the supplemental recommendations presented in this document requires addressing a number of issues, and that this will take time. The issues include provider and public education, health care provider training, availability of vaccine and VIG, developing the appropriate investigational new drug protocols, screening, strategies to minimize vaccine wastage, vaccine adverse event surveillance, and other logistical and administrative issues.

Copyright 2002 by the National Academy of Sciences. All rights reserved.
Bookshelf ID: NBK221068

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