This workshop summary was enhanced by the contributions of many individuals who graciously offered their time, expertise, and knowledge. The committee thanks all who attended and/or participated in the public workshop (Appendixes B and C).

This summary has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the National Research Council's Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We thank the following individuals for their review of this summary: Pieter de Jong of the Children's Hospital Oakland Research Institute, Oakland, CA; Vivek Kapur of the University of Minnesota, St. Paul, MN; and Bruce A. Roe of the University of Oklahoma, Norman, OK.