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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 75018-70-1
Drug Levels and Effects
Summary of Use during Lactation
Information in this record refers to the use of tauroselcholic acid Se-75 (SeHCAT; selenium-75 homocholic acid taurine) as a diagnostic agent. Information from one patient indicates that the effective radiation dose to the infant from SeHCAT excreted in breastmilk over 6 months is below any established dose limits and no special precautions are required.[1]
Drug Levels
Selenium Se 75 decays by electron capture with a physical half-life of approximately 119 days.
Maternal Levels. A nursing mother who was 3 months postpartum was given a capsule containing 370 kBq of SeHCAT as a diagnostic test. She collected 3 milk samples daily for 7 days. The effective radiation dose to the infant was 7 microSv over the 7-day period and the radiation dose over a 6-month period of exclusive breastfeeding was estimated to be 17 microSv.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Coleclough S, Comber E, Adesanya O, Rowley L. Estimation of infant radiation exposure from ingestion of breastmilk after SeHCAT capsule administration. Nucl Med Commun 2023;44:1199-200. doi:10.1097/MNM.0000000000001789 [CrossRef]
Substance Identification
Substance Name
Tauroselcholic Acid Se-75
CAS Registry Number
75018-70-1
Drug Class
Breast Feeding
Milk, Human
Radiopharmaceuticals
Selenium Radioisotopes
Diagnostic Agents
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Biologic stability of tauro-23-[75Se] selena-25-homocholic acid.[J Nucl Med. 1988]Biologic stability of tauro-23-[75Se] selena-25-homocholic acid.Monks R, Boyd GS. J Nucl Med. 1988 Aug; 29(8):1411-8.
- Imaging and retention measurements of selenium 75 homocholic acid conjugated with taurine, and the carbon 14 glycochol breath test to document ileal dysfunction due to late radiation damage.[Eur J Nucl Med. 1991]Imaging and retention measurements of selenium 75 homocholic acid conjugated with taurine, and the carbon 14 glycochol breath test to document ileal dysfunction due to late radiation damage.Olmos RV, den Hartog Jager F, Hoefnagel C, Taal B. Eur J Nucl Med. 1991; 18(2):124-8.
- Tests for the absorption of 75Se-labelled homocholic acid conjugated with taurine (75Se-HCAT).[Eur J Nucl Med. 1985]Tests for the absorption of 75Se-labelled homocholic acid conjugated with taurine (75Se-HCAT).Schroth HJ, Berberich R, Feifel G, Müller KP, Ecker KW. Eur J Nucl Med. 1985; 10(9-10):455-7.
- Review SeHCAT [tauroselcholic (selenium-75) acid] for the investigation of bile acid malabsorption and measurement of bile acid pool loss: a systematic review and cost-effectiveness analysis.[Health Technol Assess. 2013]Review SeHCAT [tauroselcholic (selenium-75) acid] for the investigation of bile acid malabsorption and measurement of bile acid pool loss: a systematic review and cost-effectiveness analysis.Riemsma R, Al M, Corro Ramos I, Deshpande SN, Armstrong N, Lee YC, Ryder S, Noake C, Krol M, Oppe M, et al. Health Technol Assess. 2013 Dec; 17(61):1-236.
- Review Challenging current views on bile acid diarrhoea and malabsorption.[Frontline Gastroenterol. 2018]Review Challenging current views on bile acid diarrhoea and malabsorption.Kurien M, Thurgar E, Davies A, Akehurst R, Andreyev J. Frontline Gastroenterol. 2018 Apr; 9(2):92-97. Epub 2017 Jun 29.
- Tauroselcholic Acid Se-75 - Drugs and Lactation Database (LactMed®)Tauroselcholic Acid Se-75 - Drugs and Lactation Database (LactMed®)
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