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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 51-75-2
Drug Levels and Effects
Summary of Use during Lactation
Most sources consider that mothers receiving antineoplastic therapy should not breastfeed, especially with alkylating agents such as mechlorethamine.[1] Because of the potential for serious adverse reactions in the breastfed infant, breastfeeding from mechlorethamine mothers should not breastfed during therapy with mechlorethamine therapy, including topical application.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Pistilli B, Bellettini G, Giovannetti E, et al. Chemotherapy, targeted agents, antiemetics and growth-factors in human milk: How should we counsel cancer patients about breastfeeding? Cancer Treat Rev. 2013;39:207–11. [PubMed: 23199900]
Substance Identification
Substance Name
Mechlorethamine
CAS Registry Number
51-75-2
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- [Pathological studies in rats injected with methyl bis (beta-chloroethyl) amine N-oxide hydrochloride (nitromin) in various ways].[Gan. 1955][Pathological studies in rats injected with methyl bis (beta-chloroethyl) amine N-oxide hydrochloride (nitromin) in various ways].YAMAMOTO T, YAMADA A. Gan. 1955 Sep; 46(2-3):376-8.
- [About the treatment of malignant tumor by nitrogen-mustard N-oxide [methyl-bis (beta-chloroethyl)-amine-N-oxide hydrochloride].[Gan. 1952][About the treatment of malignant tumor by nitrogen-mustard N-oxide [methyl-bis (beta-chloroethyl)-amine-N-oxide hydrochloride].OTSUKI K, IWAI Y. Gan. 1952 Sep; 43(2-3):175-7.
- A comparison of the retardation of Sarcoma 180 by SK 1424, 3-Bis (beta-chloroethyl) aminomethyl-4-methoxymethyl-5-hydroxy-6-methyl-pyridine with that by HN2, Methylbis (beta-chloroethyl) amine.[Cancer Res. 1951]A comparison of the retardation of Sarcoma 180 by SK 1424, 3-Bis (beta-chloroethyl) aminomethyl-4-methoxymethyl-5-hydroxy-6-methyl-pyridine with that by HN2, Methylbis (beta-chloroethyl) amine.STOCK CC, BUCKLEY S, SUGIURA K, RHOADS CP. Cancer Res. 1951 Jun; 11(6):432-6.
- Review Cyclophosphamide.[Drugs and Lactation Database (...]Review Cyclophosphamide.. Drugs and Lactation Database (LactMed®). 2006
- Review Mechanism of action of chlormethine gel in mycosis fungoides.[J Eur Acad Dermatol Venereol. ...]Review Mechanism of action of chlormethine gel in mycosis fungoides.Guenova E, Ortiz-Romero PL, Poligone B, Querfeld C. J Eur Acad Dermatol Venereol. 2023 Sep; 37(9):1739-1748. Epub 2023 Jul 1.
- Mechlorethamine - Drugs and Lactation Database (LactMed®)Mechlorethamine - Drugs and Lactation Database (LactMed®)
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