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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 14158-31-7
Drug Levels and Effects
Summary of Use during Lactation
Iodine I-125 is implanted temporarily in a sealed container (plaque) to treat localized tumors. During the time that the plaque is in place, the mother and infant must be separated to avoid radiation exposure to the infant. The mother’s milk is not affected, and it can be pumped and fed to the infant at a later time.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
A mother nursing an 11-month-old infant was treated with an iodine I-125 plaque for uveal melanoma. The plaque was in place for 2 days during which time she was separated from her infant, but pumped milk for later use. Breastfeeding was resumed after plaque removal.[1]
References
- 1.
- Rieth E, Barnett K, Simon J. Perioperative management of a lactating cancer patient undergoing surgical placement and removal of an iodine-125 brachytherapy plaque for uveal melanoma. Breastfeed Med. 2020;15:A3–A4. [CrossRef]
Substance Identification
Substance Name
Iodine I-125
CAS Registry Number
14158-31-7
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- Review The Duration, Frequency, and Volume of Exclusive Human Milk and/or Infant Formula Consumption and Nutrient Status: A Systematic Review[ 2020]Review The Duration, Frequency, and Volume of Exclusive Human Milk and/or Infant Formula Consumption and Nutrient Status: A Systematic ReviewDewey K, Bazzano L, Davis T, Donovan S, Taveras E, Kleinman R, Güngör D, Madan E, Venkatramanan S, Terry N, et al. 2020 Jul
- Is there any difference between the iodine statuses of breast-fed and formula-fed infants and their mothers in an area with iodine sufficiency?[Br J Nutr. 2018]Is there any difference between the iodine statuses of breast-fed and formula-fed infants and their mothers in an area with iodine sufficiency?Nazeri P, Dalili H, Mehrabi Y, Hedayati M, Mirmiran P, Azizi F. Br J Nutr. 2018 May; 119(9):1012-1018. Epub 2018 Mar 5.
- Independent of Birth Mode or Gestational Age, Very-Low-Birth-Weight Infants Fed Their Mothers' Milk Rapidly Develop Personalized Microbiotas Low in Bifidobacterium.[J Nutr. 2018]Independent of Birth Mode or Gestational Age, Very-Low-Birth-Weight Infants Fed Their Mothers' Milk Rapidly Develop Personalized Microbiotas Low in Bifidobacterium.Butcher J, Unger S, Li J, Bando N, Romain G, Francis J, Mottawea W, Mack D, Stintzi A, O'Connor DL. J Nutr. 2018 Mar 1; 148(3):326-335.
- Mother-infant skin-to-skin contact after delivery results in early recognition of own mother's milk odour.[Acta Paediatr. 2004]Mother-infant skin-to-skin contact after delivery results in early recognition of own mother's milk odour.Mizuno K, Mizuno N, Shinohara T, Noda M. Acta Paediatr. 2004 Dec; 93(12):1640-5.
- Review Transfer of 131I into human breast milk and transfer coefficients for radiological dose assessments.[Health Phys. 2002]Review Transfer of 131I into human breast milk and transfer coefficients for radiological dose assessments.Simon SL, Luckyanov N, Bouville A, VanMiddlesworth L, Weinstock RM. Health Phys. 2002 Jun; 82(6):796-806.
- Iodine I-125 - Drugs and Lactation Database (LactMed®)Iodine I-125 - Drugs and Lactation Database (LactMed®)
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