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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 109889-09-0
Drug Levels and Effects
Summary of Use during Lactation
No information is available on the use of granisetron during breastfeeding. Until more data become available, granisetron should be used with caution during breastfeeding. An alternate drug may be preferred.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
A woman nursing an 8-month-old infant 6 to 8 times daily was admitted to the hospital for an appendectomy. During the procedure she received granisetron, cefazolin, ketorolac, rocuronium, succinylcholine, and sufentanil. The patient also received 2 boluses of intravenous propofol of 150 mg followed shortly thereafter by a 50 mg dose. Postoperatively, she was receiving acetaminophen, cefazolin, ibuprofen, and pantoprazole, as well as oxycodone and dimenhydrinate as needed. Twenty-two hours after the procedure, the mother extracted milk for the first time and noted it to be light green in color. Analysis of the green milk using a nonvalidated assay detected no propofol. The green color faded and was absent by postoperative day 4 when she resumed breastfeeding. The authors judged that the green color was possibly caused by propofol or one of its metabolites.[1]
Alternate Drugs to Consider
References
- 1.
- Rainone A, Delucilla L, Elofer S, et al. Propofol-induced green breast milk: A case report. Can J Hosp Pharm. 2018;71:389–91. [PMC free article: PMC6306180] [PubMed: 30626986]
Substance Identification
Substance Name
Granisetron
CAS Registry Number
109889-09-0
Drug Class
Breast Feeding
Antiemetics
Gastrointestinal Agents
Serotonin Antagonists
Serotonin 5-HT3 Receptor Antagonists
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Review Dolasetron.[Drugs and Lactation Database (...]Review Dolasetron.. Drugs and Lactation Database (LactMed®). 2006
- Response heterogeneity of 5-HT3 receptor antagonists in a rat visceral hypersensitivity model.[Eur J Pharmacol. 1996]Response heterogeneity of 5-HT3 receptor antagonists in a rat visceral hypersensitivity model.Langlois A, Pascaud X, Junien JL, Dahl SG, Rivière PJ. Eur J Pharmacol. 1996 Dec 27; 318(1):141-4.
- Review Palonosetron.[Drugs and Lactation Database (...]Review Palonosetron.. Drugs and Lactation Database (LactMed®). 2006
- Granisetron, an antiemetic drug, and its cobalt complex.[Acta Crystallogr C. 2010]Granisetron, an antiemetic drug, and its cobalt complex.Ravikumar K, Sridhar B. Acta Crystallogr C. 2010 Feb; 66(Pt 2):m35-9. Epub 2010 Jan 15.
- Effects of granisetron, a 5-HT3 receptor antagonist, on morphine-induced potentiation of brain stimulation reward.[Eur J Pharmacol. 1995]Effects of granisetron, a 5-HT3 receptor antagonist, on morphine-induced potentiation of brain stimulation reward.Rompré PP, Injoyan R, Hagan JJ. Eur J Pharmacol. 1995 Dec 20; 287(3):263-9.
- Granisetron - Drugs and Lactation Database (LactMed®)Granisetron - Drugs and Lactation Database (LactMed®)
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