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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 38398-32-2
Drug Levels and Effects
Summary of Use during Lactation
No published information is available on the clinical use of ganaxolone during breastfeeding. However, a study by the manufacturer indicates that amounts in breastmilk appear to be low and would not be expected to cause any adverse effects in breastfed infants.
Drug Levels
Maternal Levels. The manufacturer reports that a study was conducted in 5 healthy adult lactating women treated with a single 300 mg oral dose of ganaxolone. The calculated maximum relative infant dose for ganaxolone was approximately 0.157 mg/kg daily based on an average milk intake of 150 mL/kg daily, which is less than 1% of the maternal dose, and approximately 0.24% the labeled pediatric dose of 63 mg/kg/day.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Substance Identification
Substance Name
Ganaxolone
CAS Registry Number
38398-32-2
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.[J Pharmacol Exp Ther. 1997]Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.Carter RB, Wood PL, Wieland S, Hawkinson JE, Belelli D, Lambert JJ, White HS, Wolf HH, Mirsadeghi S, Tahir SH, et al. J Pharmacol Exp Ther. 1997 Mar; 280(3):1284-95.
- Review Brexanolone.[Drugs and Lactation Database (...]Review Brexanolone.. Drugs and Lactation Database (LactMed®). 2006
- Antinociceptive effects of the neuroactive steroid, 3alpha-hydroxy-5alpha-pregnan-20-one and progesterone in the land snail, Cepaea nemoralis.[Neuroscience. 2000]Antinociceptive effects of the neuroactive steroid, 3alpha-hydroxy-5alpha-pregnan-20-one and progesterone in the land snail, Cepaea nemoralis.Kavaliers M, Perrot-Sinal TS, Desjardins DC, Cross-Mellor SK, Wiebe JP. Neuroscience. 2000; 95(3):807-12.
- Allopregnanolone and ganaxolone increase the firing activity of dorsal raphe nucleus serotonergic neurons in female rats.[Int J Neuropsychopharmacol. 2006]Allopregnanolone and ganaxolone increase the firing activity of dorsal raphe nucleus serotonergic neurons in female rats.Robichaud M, Debonnel G. Int J Neuropsychopharmacol. 2006 Apr; 9(2):191-200. Epub 2005 Sep 21.
- Review Ganaxolone.[Neurotherapeutics. 2007]Review Ganaxolone.Nohria V, Giller E. Neurotherapeutics. 2007 Jan; 4(1):102-5.
- Ganaxolone - Drugs and Lactation Database (LactMed®)Ganaxolone - Drugs and Lactation Database (LactMed®)
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