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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 2101630-92-4
Drug Levels and Effects
Summary of Use during Lactation
Edotreotide gallium Ga-68 (Ga 68 Dotatoc) is used for localization of somatostatin receptor positive neuroendocrine tumors. Labeling in the U.S. advises nursing mothers to pump and discard breastmilk for 8 hours after a dose.
Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at a safe level, she may resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published.[1]
Nursing mothers should not work with radioactive substances used in PET scans in their workplace.[2]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Stabin MG, Breitz HB. Breast milk excretion of radiopharmaceuticals: Mechanisms, findings, and radiation dosimetry. J Nucl Med. 2000;41:863–73. [PubMed: 10809203]
- 2.
- Almén A, Mattsson S. Radiological protection of foetuses and breast-fed children of occupationally exposed women in nuclear medicine - Challenges for hospitals. Phys Med. 2017;43:172–7. [PubMed: 28882410]
Substance Identification
Substance Name
Edotreotide Gallium Ga-68
CAS Registry Number
2101630-92-4
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Ga-66 labeled somatostatin analogue DOTA-DPhe1-Tyr3-octreotide as a potential agent for positron emission tomography imaging and receptor mediated internal radiotherapy of somatostatin receptor positive tumors.[Nucl Med Biol. 2002]Ga-66 labeled somatostatin analogue DOTA-DPhe1-Tyr3-octreotide as a potential agent for positron emission tomography imaging and receptor mediated internal radiotherapy of somatostatin receptor positive tumors.Ugur O, Kothari PJ, Finn RD, Zanzonico P, Ruan S, Guenther I, Maecke HR, Larson SM. Nucl Med Biol. 2002 Feb; 29(2):147-57.
- Review Lutetium Lu 177 Dotatate.[Drugs and Lactation Database (...]Review Lutetium Lu 177 Dotatate.. Drugs and Lactation Database (LactMed®). 2006
- Prospective Within-Patient Assessment of the Impact of an Unlabeled Octreotide Pre-dose on the Biodistribution and Tumor Uptake of (68)Ga DOTATOC as Assessed by Dynamic Whole-body PET in Patients with Neuroendocrine Tumors: Implications for Diagnosis and Therapy.[Mol Imaging Biol. 2021]Prospective Within-Patient Assessment of the Impact of an Unlabeled Octreotide Pre-dose on the Biodistribution and Tumor Uptake of (68)Ga DOTATOC as Assessed by Dynamic Whole-body PET in Patients with Neuroendocrine Tumors: Implications for Diagnosis and Therapy.Lodge MA, Solnes LB, Chaudhry MA, Wahl RL. Mol Imaging Biol. 2021 Oct; 23(5):766-774. Epub 2021 Apr 7.
- Edotreotide Gallium Ga-68 - Drugs and Lactation Database (LactMed®)Edotreotide Gallium Ga-68 - Drugs and Lactation Database (LactMed®)
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