Copyright Notice
Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.
Bookshelf ID: NBK572247PMID: 34292693
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
Drug Levels and Effects
Summary of Use during Lactation
Crotalidae Immune F(ab')2 (equine) is used to treat crotalid envenomation (rattlesnakes, copperheads, cottonmouths, water moccasins). No information is available on the clinical use of crotalidae antivenin, polyvalent (equine) during breastfeeding. Because it is a mixture of large protein molecule, the amounts in milk are likely to be very low.[1] They are also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal.[2] The possibility of sensitization to horse proteins should be kept in mind.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Stratigakis A, Paty D, Zou P, et al. A regression approach for assessing large molecular drug concentration in breast milk. Reprod Breed 2023;3:199-207. doi:10.1016/j.repbre.2023.10.003 [CrossRef]
- 2.
- Anderson PO. Monoclonal antibodies during breastfeeding. Breastfeed Med 2021;16:591-3. [PubMed: 33956488]
Substance Identification
Substance Name
Crotalidae Immune F(ab')2 (Equine)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
- User and Medical Advice Disclaimer
- Drugs and Lactation Database (LactMed) - Record Format
- LactMed - Database Creation and Peer Review Process
- Fact Sheet. Drugs and Lactation Database (LactMed)
- Drugs and Lactation Database (LactMed) - Glossary
- LactMed Selected References
- Drugs and Lactation Database (LactMed) - About Dietary Supplements
- Breastfeeding Links
- PubMedLinks to PubMed
- Review Crotalidae Polyvalent Immune Fab.[Drugs and Lactation Database (...]Review Crotalidae Polyvalent Immune Fab.. Drugs and Lactation Database (LactMed®). 2006
- Review Crotalidae Polyvalent Immune Fab (Ovine).[Drugs and Lactation Database (...]Review Crotalidae Polyvalent Immune Fab (Ovine).. Drugs and Lactation Database (LactMed®). 2006
- Use of both Fab and F(ab')(2) fragment antivenom in a pediatric patient for treatment of a North American Crotalidae envenomation.[Am J Emerg Med. 2021]Use of both Fab and F(ab')(2) fragment antivenom in a pediatric patient for treatment of a North American Crotalidae envenomation.Martin AM, Wang GS, Poel K. Am J Emerg Med. 2021 Jul; 45:677.e1-677.e3. Epub 2020 Nov 24.
- Late hemotoxicity following North American rattlesnake envenomation treated with crotalidae immune F(ab')(2) (equine) antivenom and crotalidae immune polyvalent Fab (ovine) antivenom reported to the North American Snakebite Sub-registry.[Clin Toxicol (Phila). 2022]Late hemotoxicity following North American rattlesnake envenomation treated with crotalidae immune F(ab')(2) (equine) antivenom and crotalidae immune polyvalent Fab (ovine) antivenom reported to the North American Snakebite Sub-registry.Spyres MB, Padilla GK, Gerkin RD, Hoyte CO, Wolk BJ, Ruha AM, ToxIC Snakebite Study Group. Clin Toxicol (Phila). 2022 Jul; 60(7):838-842. Epub 2022 Mar 9.
- Failure of Crotalidae Immune F(ab')(2) Equine Antivenom to Achieve Control in a Southern Pacific Rattlesnake Envenomation.[Ann Emerg Med. 2022]Failure of Crotalidae Immune F(ab')(2) Equine Antivenom to Achieve Control in a Southern Pacific Rattlesnake Envenomation.Levine M, Spungen H, Pizon AF. Ann Emerg Med. 2022 Dec; 80(6):525-527. Epub 2022 Aug 9.
- Crotalidae Immune F(ab')2 (Equine) - Drugs and Lactation Database (LactMed®)Crotalidae Immune F(ab')2 (Equine) - Drugs and Lactation Database (LactMed®)
Your browsing activity is empty.
Activity recording is turned off.
See more...