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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 32886-97-8
Drug Levels and Effects
Summary of Use during Lactation
Amdinocillin (pivmecillinam; the pivaloyl ester of mecillinam) is not commercially available in the United States, but is marketed internationally. Limited information indicates that amdinocillin produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Monitor the breastfed infant for diarrhea and thrush.
Drug Levels
Maternal Levels. Four women who were 4 or 6 days postpartum were given a single 100 mg dose of amdinocillin. The drug was not detectable in breastmilk 1 or 3 hours after the dose, although the sensitivity of the assay is unknown.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Seiga K, Minagawa M, Yamaji K, et al. Studies on pivmecillinam. Chemotherapy (Tokyo). 1977;25:347–51. [CrossRef]
Substance Identification
Substance Name
Amdinocillin
CAS Registry Number
32886-97-8
Drug Class
Breast Feeding
Milk, Human
Anti-Infective Agents, Urinary
Anti-Bacterial Agents
Beta-Lactams
Penicillins
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- LC-MS/MS methods for determination of unstable pivmecillinam and mecillinam in acidified human plasma: Application to a pharmacokinetic study.[J Sep Sci. 2022]LC-MS/MS methods for determination of unstable pivmecillinam and mecillinam in acidified human plasma: Application to a pharmacokinetic study.Sun LN, Zhao Y, Gao HY, Yang YL, Qian XP, Sun SY, Wang Y, Ding L, Wang YQ. J Sep Sci. 2022 Jul; 45(14):2543-2554. Epub 2022 Jun 2.
- Mutational change of CTX-M-15 to CTX-M-127 resulting in mecillinam resistant Escherichia coli during pivmecillinam treatment of a patient.[Microbiologyopen. 2019]Mutational change of CTX-M-15 to CTX-M-127 resulting in mecillinam resistant Escherichia coli during pivmecillinam treatment of a patient.Nielsen KL, Hansen KH, Nielsen JB, Knudsen JD, Schønning K, Frimodt-Møller N, Hertz FB, Jansåker F. Microbiologyopen. 2019 Dec; 8(12):e941. Epub 2019 Oct 1.
- Factors influencing the absorption and disposition of mecillinam and pivmecillinam in man.[Br J Clin Pharmacol. 1976]Factors influencing the absorption and disposition of mecillinam and pivmecillinam in man.Andrews J, Kendall MJ, Mitchard M. Br J Clin Pharmacol. 1976 Aug; 3(4):627-32.
- Amdinocillin - Drugs and Lactation Database (LactMed®)Amdinocillin - Drugs and Lactation Database (LactMed®)
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