Summary of Use during Lactation

Varenicline is a partial nicotine agonist used to assist smoking cessation. One researcher points out that based on animal data on nicotine, varenicline might interfere with normal infant lung development and recommends against its use in nursing mothers.[1] Because no information is available on the use of varenicline during breastfeeding, an alternate drug is preferred, especially while nursing a newborn or preterm infant.[2] If a mother chooses to breastfeed while taking varenicline, she should monitor her infant for seizures and excessive vomiting.[3]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

(Smoking Cessation) Bupropion

References

1.

Maritz GS. Are nicotine replacement therapy, varenicline or bupropion options for pregnant mothers to quit smoking? Effects on the respiratory system of the offspring. Ther Adv Respir Dis 2009;3:193-210. [PubMed: 19706643]

2.

McAllister-Williams RH, Baldwin DS, Cantwell R, et al. British Association for Psychopharmacology consensus guidance on the use of psychotropic medication preconception, in pregnancy and postpartum 2017. J Psychopharmacol 2017;31:519-52. [PubMed: 28440103]

3.

Harris M, Schiff DM, Saia K, et al. Academy of Breastfeeding Medicine Clinical Protocol #21: Breastfeeding in the setting of substance use and substance use disorder (Revised 2023). Breastfeed Med 2023;18:715-733. [PubMed: 37856658]

Substance Name

Varenicline

CAS Registry Number

249296-44-4

Drug Class

Breast Feeding

Lactation

Milk, Human

Nicotinic Agonists