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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 60-80-0
Drug Levels and Effects
Summary of Use during Lactation
Antipyrine is considered unlikely to harm the infant.[1] Because antipyrine is available in the US only in ear drops, it is unlikely to be absorbed by the mother and reach the breastmilk. No special precautions are required during maternal use of antipyrine-containing ear drops.
Drug Levels
Maternal Levels. Antipyrine was given to 7 lactating women who were 2 to 19 months postpartum. Each woman drank a single oral dose of 18 mg/kg of antipyrine in solution. Peak milk levels usually occurred 10 minutes after ingestion and ranged from about 10 to 30 mg/L. The antipyrine half-life in milk averaged 11.6 hours (range 5.7 to 21.7 hours). The authors estimated that a fully breastfed infant would ingest 6.4 mg of antipyrine after this maternal dose or 0.59% of the maternal dose (not weight-adjusted). Two of the women who were studied before and after pregnancy indicated that antipyrine clearance might be increased by about two-fold during lactation.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Berlin CM Jr, Vesell S. Antipyrine disposition in milk and saliva of lactating women. Clin Pharmacol Ther. 1982;31:38–44. [PubMed: 7053302]
Substance Identification
Substance Name
Antipyrine
CAS Registry Number
60-80-0
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- [On the metabolism of antipyrine (phenazone) in man (author's transl)].[Arzneimittelforschung. 1978][On the metabolism of antipyrine (phenazone) in man (author's transl)].Zietz E, Eichelbaum M, Dengler HJ, Spiteller G. Arzneimittelforschung. 1978; 28(2):315-9.
- Antipyrine - Drugs and Lactation Database (LactMed®)Antipyrine - Drugs and Lactation Database (LactMed®)
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