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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 1397-89-3
Drug Levels and Effects
Summary of Use during Lactation
Although no information exists on the milk excretion of amphotericin B, it is highly protein bound, has a large molecular weight, is virtually unabsorbed orally and has been use directly in the mouths of infants;[1] therefore, most reviewers consider it acceptable to use in nursing mothers.[2,3]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
(Systemic) Fluconazole; (Topical) Clotrimazole, Miconazole, Nystatin
References
- 1.
- Hoppe JE. Treatment of oropharyngeal candidiasis and candidal diaper dermatitis in neonates and infants: Review and reappraisal. Pediatr Infect Dis J. 1997;16:885–94. [PubMed: 9306485]
- 2.
- Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001;17:160–6. [PubMed: 11847833]
- 3.
- Ilett KF, Kristensen JH. Drug use and breastfeeding. Expert Opin Drug Saf. 2005;4:745–68. [PubMed: 16011452]
Substance Identification
Substance Name
Amphotericin B
CAS Registry Number
1397-89-3
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Isolation, structure elucidation and activity of an unknown impurity of amphotericin B.[J Antibiot (Tokyo). 2007]Isolation, structure elucidation and activity of an unknown impurity of amphotericin B.Li J, Zhu HQ, Li JY, Jin SH, Hu CQ. J Antibiot (Tokyo). 2007 Apr; 60(4):272-6.
- A newly identified derivative of amphotericin B: isolation, structure determination and primary evaluation of the activity and toxicity.[J Antibiot (Tokyo). 2010]A newly identified derivative of amphotericin B: isolation, structure determination and primary evaluation of the activity and toxicity.Wang YH, Zhang JP, Chang Y, Hu CQ. J Antibiot (Tokyo). 2010 Sep; 63(9):553-7. Epub 2010 Jul 7.
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- Amphotericin B - Drugs and Lactation Database (LactMed®)Amphotericin B - Drugs and Lactation Database (LactMed®)
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