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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 53179-11-6
Drug Levels and Effects
Summary of Use during Lactation
Use of loperamide during breastfeeding is unlikely to affect the infant.
Drug Levels
Maternal Levels. Loperamide has not been studied during breastfeeding, but the loperamide prodrug, loperamide oxide, has been studied in a dosage of 2 doses of 4 mg given 12 hours apart to 6 women 18 to 47 hours after delivery. Median loperamide milk concentrations were 0.18 mcg/L at 12 hours after the first dose, 0.27 mcg/L at 6 hours after the second dose, and 0.19 mcg/L at 24 hours after the second dose.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Nikodem VC, Hofmeyr GJ. Secretion of the antidiarrhoeal agent loperamide oxide in breast milk. Eur J Clin Pharmacol. 1992;42:695–6. [PubMed: 1623917]
Substance Identification
Substance Name
Loperamide
CAS Registry Number
53179-11-6
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