Copyright Notice
Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.
Bookshelf ID: NBK501036PMID: 30000095
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 7416-34-4
Drug Levels and Effects
Summary of Use during Lactation
Because there is no published experience with molindone during breastfeeding, other antipsychotic agents are preferred.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Galactorrhea has been reported with molindone.[1,2] Hyperprolactinemia appears to be the cause of the galactorrhea.[3-5] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[6] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
References
- 1.
- Kahn JL. More on galactorrhea associated with molindone. Am J Psychiatry 1979;136:1617-8. Letter. PMID: 574364. [PubMed: 574364]
- 2.
- Wesp CE Jr, Annitto W, Feinsod R. Galactorrhea associated with molindone. Am J Psychiatry. 1979;136:975. [PubMed: 572143]
- 3.
- Turkington RW. Prolactin secretion in patients treated with various drugs: phenothiazines, tricyclic antidepressants, reserpine, and methyldopa. Arch Intern Med. 1972;130:349–54. [PubMed: 4560178]
- 4.
- Turkington RW. Serum prolactin levels in patients with gynecomastia. J Clin Endocrinol Metab. 1972;34:62–6. [PubMed: 5061776]
- 5.
- Meltzer HY, Fang VS. The effect of neuroleptics on serum prolactin in schizophrenic patients. Arch Gen Psychiatry. 1976;33:279–86. [PubMed: 1259521]
- 6.
- Maguire GA. Prolactin elevation with antipsychotic medications: Mechanisms of action and clinical consequences. J Clin Psychiatry. 2002;63 Suppl 4:56–62. [PubMed: 11913677]
Substance Identification
Substance Name
Molindone
CAS Registry Number
7416-34-4
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
- User and Medical Advice Disclaimer
- Drugs and Lactation Database (LactMed) - Record Format
- LactMed - Database Creation and Peer Review Process
- Fact Sheet. Drugs and Lactation Database (LactMed)
- Drugs and Lactation Database (LactMed) - Glossary
- LactMed Selected References
- Drugs and Lactation Database (LactMed) - About Dietary Supplements
- Breastfeeding Links
- PubChem SubstanceRelated PubChem Substances
- PubMedLinks to PubMed
- Review Mesoridazine.[Drugs and Lactation Database (...]Review Mesoridazine.. Drugs and Lactation Database (LactMed®). 2006
- Review Ropinirole.[Drugs and Lactation Database (...]Review Ropinirole.. Drugs and Lactation Database (LactMed®). 2006
- Review Protriptyline.[Drugs and Lactation Database (...]Review Protriptyline.. Drugs and Lactation Database (LactMed®). 2006
- Review Ziprasidone.[Drugs and Lactation Database (...]Review Ziprasidone.. Drugs and Lactation Database (LactMed®). 2006
- Review Nedocromil.[Drugs and Lactation Database (...]Review Nedocromil.. Drugs and Lactation Database (LactMed®). 2006
- Molindone - Drugs and Lactation Database (LactMed®)Molindone - Drugs and Lactation Database (LactMed®)
Your browsing activity is empty.
Activity recording is turned off.
See more...