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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 608141-41-9
Drug Levels and Effects
Summary of Use during Lactation
No information is available on the clinical use of apremilast during breastfeeding. Although it is not contraindicated, international guidelines and reviews recommend avoiding apremilast during breastfeeding.[1-4] An alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
(Rheumatoid Arthritis) Etanercept, Gold Sodium Thiomalate, Hydroxychloroquine, Infliximab, Methotrexate, Penicillamine, Sulfasalazine
References
- 1.
- Rademaker M, Agnew K, Andrews M, et al. Psoriasis in those planning a family, pregnant or breast-feeding. The Australasian Psoriasis Collaboration. Australas J Dermatol 2018;59:86-100. [PubMed: 28543445]
- 2.
- Puchner A, Grochenig HP, Sautner J, et al. Immunosuppressives and biologics during pregnancy and lactation: A consensus report issued by the Austrian Societies of Gastroenterology and Hepatology and Rheumatology and Rehabilitation. Wien Klin Wochenschr 2019;131:29-44. [PMC free article: PMC6342891] [PubMed: 30643992]
- 3.
- Belinchón I, Velasco M, Ara-Martín M, et al. [Management of psoriasis during preconception, pregnancy, postpartum, and breastfeeding: A consensus statement]. Actas Dermosifiliogr (Engl Ed) 2021;112:225-41. [PubMed: 33065101]
- 4.
- Yaghi M, McMullan P, Truong TM, et al. Safety of dermatologic medications in pregnancy and lactation: An Update - Part II: Lactation. J Am Acad Dermatol 2024. [PubMed: 38280680]
Substance Identification
Substance Name
Apremilast
CAS Registry Number
608141-41-9
Drug Class
Breastfeeding
Milk, Human
Analgesics
Antirheumatic Agents
Enzyme Inhibitors
Phosphodiesterase Inhibitors
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- PubMedLinks to PubMed
- Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor.[J Med Chem. 2009]Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor.Man HW, Schafer P, Wong LM, Patterson RT, Corral LG, Raymon H, Blease K, Leisten J, Shirley MA, Tang Y, et al. J Med Chem. 2009 Mar 26; 52(6):1522-4.
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- Apremilast - Drugs and Lactation Database (LactMed®)Apremilast - Drugs and Lactation Database (LactMed®)
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