Summary of Use during Lactation

No information is available on the amount of hydroflumethiazide in breastmilk. Intense diuresis with large doses may decrease breastmilk production. Other diuretics in low doses are preferred over hydroflumethiazide.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information on hydroflumethiazide was not found as of the revision date. Intense diuresis with thiazides and thiazide-like diuretics, fluid restriction and breast binding have been used to suppress postpartum lactation.[1-3] The added contribution of the diuretic to these measures, which are effective in suppressing lactation, has not been studied. There are no data on the effects of diuretics on established, ongoing lactation.

Alternate Drugs to Consider

Chlorothiazide, Hydrochlorothiazide

References

1.

Healy M. Suppressing lactation with oral diuretics. Lancet. 1961;277:1353–4.

2.

Reiher KH. Zentralbl Gynakol. 1963;85:188–90. [Suppression of lactation by stimulation of diuresis] [PubMed: 13973786]

3.

Stout G. Suppression of lactation. Br Med J 1962;1:1150. Letter. PMC1958377.

Substance Name

Hydroflumethiazide

CAS Registry Number

135-09-1

Drug Class

Breast Feeding

Lactation

Antihypertensive Agents

Thiazide Diuretics