Summary of Use during Lactation

No information is available on the clinical use of sugammadex during breastfeeding. Because sugammadex is a large, highly polar molecule with a molecular weight of 2002 Da., the amount in milk is likely to be very low and oral absorption by the infant is unlikely. Sugammadex is acceptable to use during breastfeeding.[1-3]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Neostigmine

References

1.

Reece-Stremtan S, Campos M, Kokajko L, et al. ABM Clinical Protocol #15: Analgesia and anesthesia for the breastfeeding mother, revised 2017. Breastfeed Med. 2017;12:500–6. [PubMed: 29624435]

2.

Richardson MG, Raymond BL. Sugammadex administration in pregnant women and in women of reproductive potential: A narrative review. Anesth Analg. 2020;130:1628–37. [PubMed: 31283616]

3.

Hirsch JG, Chia PA, Jahr JS. Sugammadex: A review of the considerations for women of childbearing age. Am J Ther. 2023;30:e146–e150. [PubMed: 36892560]

Substance Name

Sugammadex

CAS Registry Number

343306-71-8

Drug Class

Breast Feeding

Lactation

Milk, Human

Antidotes

Gamma-Cyclodextrins

Neuromuscular Blockade