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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 50936-59-9
Drug Levels and Effects
Summary of Use during Lactation
No information is available on the clinical use of idursulfase during breastfeeding. Because it is a large protein molecule with a molecular weight of about 76,000 Da, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Substance Identification
Substance Name
Idursulfase
CAS Registry Number
50936-59-9
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Biodistribution of Idursulfase Formulated for Intrathecal Use (Idursulfase-IT) in Cynomolgus Monkeys after Intrathecal Lumbar Administration.[PLoS One. 2016]Biodistribution of Idursulfase Formulated for Intrathecal Use (Idursulfase-IT) in Cynomolgus Monkeys after Intrathecal Lumbar Administration.Chung JK, Brown E, Crooker B, Palmieri KJ, McCauley TG. PLoS One. 2016; 11(10):e0164765. Epub 2016 Oct 20.
- Review Sincalide.[Drugs and Lactation Database (...]Review Sincalide.. Drugs and Lactation Database (LactMed®). 2006
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- alpha-L-iduronidase, beta-D-glucuronidase, and 2-sulfo-L-iduronate 2-sulfatase: preparation and characterization of radioactive substrates from heparin.[Carbohydr Res. 1979]alpha-L-iduronidase, beta-D-glucuronidase, and 2-sulfo-L-iduronate 2-sulfatase: preparation and characterization of radioactive substrates from heparin.Hopwood JJ. Carbohydr Res. 1979 Mar; 69:203-16.
- Pharmacokinetics and bioavailability of a therapeutic enzyme (idursulfase) in cynomolgus monkeys after intrathecal and intravenous administration.[PLoS One. 2015]Pharmacokinetics and bioavailability of a therapeutic enzyme (idursulfase) in cynomolgus monkeys after intrathecal and intravenous administration.Xie H, Chung JK, Mascelli MA, McCauley TG. PLoS One. 2015; 10(4):e0122453. Epub 2015 Apr 2.
- Idursulfase - Drugs and Lactation Database (LactMed®)Idursulfase - Drugs and Lactation Database (LactMed®)
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