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Relationship between volume of services and quality of treatment outcome for stem cell transplantations – Update on commission V18-021
Institute for Quality and Efficiency in Health Care (IQWiG).
Key statement
Research question:
The objective of this investigation is to update Rapid Report V18-02. Hence, this rapid report aims to answer the same research questions as Rapid Report V18-02:
– present and assess the correlation between volume and quality of treatment outcome in allogeneic stem cell transplantation (SCT) in adults (research question 1a)
– present and assess the correlation between volume and quality of treatment outcome in autologous SCT in adults (research question 1b)
– present and assess studies which investigate the effects of a minimum number of cases of SCT introduced into the healthcare system on the quality of treatment outcomes (research question 2)
Conclusion:
For the investigation of any correlation between volume and quality of treatment outcome in allogeneic SCT (research question 1a) and autologous SCT (research question 1b), the present rapid report was able to include 1 observational study each. Both studies investigated volume solely on the transplantation centre (TC) level and quality of treatment outcome solely for the outcome of all-cause mortality.
Regarding allogeneic SCT, on the basis of 1 study of high informative value of results, the present rapid report derived a correlation between volume and quality of treatment outcome in favour of higher-volume TCs for the outcome of all-cause mortality. This result supports the conclusion of Rapid Report V18-02.
Regarding autologous SCT, the 1 study of low informative value of results did not allow the present rapid report to derive any correlation between TC volume and quality of treatment outcome. This result does not alter the conclusion of Rapid Report V18-02, which derived a correlation.
No studies were found for investigating the effects of specific minimum case numbers implemented in patient care for SCT on the quality of treatment outcomes (research question 2).
Keywords:
Minimum Volume, Stem Cell Transplantation, Systematic ReviewContents
Publishing details
Publisher
Institute for Quality and Efficiency in Health Care
Topic
Relationship between volume of services and quality of treatment outcome for stem cell transplantations – Update on commission V18-02
Commissioning agency
Federal Joint Committee
Commission awarded on
15 April 2021
Internal Commission No.
V21-04
Address of publisher
This report on the update of rapid report V18-02 was prepared without collaboration of external experts.
The responsibility for the contents of the report lies solely with IQWiG.
IQWiG employees
- Eva Höfer
- Lutz Altenhofen
- Corinna Ernsting
- Mandy Kromp
- Jona Lilienthal
- Annika Orland
- Dorothea Sow
- 1
Translation of Chapters 1 to 7 of the rapid report V21-04 Zusammenhang zwischen Leistungsmenge und Qualität des Behandlungsergebnisses bei Stammzelltransplantationen – Aktualisierung zum Auftrag V18-02 (Version 1.0; Status: 2 August 2021 [German original], 20 January 2022 [English translation]). Please note: This document was translated by an external translator and is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding.
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