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The aims of this investigation are to
- assess the benefit of treatment with non-drug interventions in comparison with one another, with drug treatment, with sham treatment, or with no treatment in patients with advanced lymphoedema (stage II or above) with regard to patient-relevant outcomes,
- determine the (intervention) costs of treatment with non-drug interventions in comparison with each other, with drug treatment, with sham treatment, or with no treatment in patients with advanced lymphoedema,
- assess the cost effectiveness of treatment with non-drug interventions in comparison with each other, with drug treatment, with sham treatment, or with no treatment in patients with advanced lymphoedema, and
- review ethical, social, legal, and organizational aspects associated with the medical intervention.
Keywords:
Lymphoedema, Elephantiasis, Benefit Assessment, Systematic Review, Technology Assessment – BiomedicalContents
Publishing details
Publisher
Institute for Quality and Efficiency in Health Care (IQWiG)
Topic
Advanced lymphoedema: Can non-drug interventions alleviate symptoms?
HTA No.
HT19-01
Date of project start
14 November 2019
Address of publisher
Authors
- Heike Raatz, Institute for Evidence in Medicine, Faculty of Medicine, University of Freiburg, Freiburg, Germany
- Blin Nagavci, Institute for Evidence in Medicine, Faculty of Medicine, University of Freiburg, Freiburg, Germany
- Klaus Kaier, Institute of Medical Biometry and Statistics, Faculty of Medicine, University of Freiburg, Freiburg, Germany
- Anne Göhner, Centre for Geriatric Medicine and Gerontology, Faculty of Medicine, University of Freiburg, Freiburg, Germany
- Joachim Boldt, Institute for Ethics and History of Medicine, University of Freiburg, Freiburg, Germany
- Susanne Beck, Institute for Forensic Science (Kriminalwissenschaftliches Institut), Leibniz University Hanover, Hanover, Germany
- Valérie Labonté, Institute for Evidence in Medicine, Faculty of Medicine, University of Freiburg, Freiburg, Germany
- Christine Schmucker, Institute for Evidence in Medicine, Faculty of Medicine, University of Freiburg, Freiburg, Germany
- Cordula Braun, Cochrane Germany Foundation and Institute for Evidence in Medicine, Freiburg, Germany
- Jörg Meerpohl, Institute for Evidence in Medicine, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Scientific advisor
- Jochen Karl Rössler, Paediatric Haematology / Oncology, Inselspital, University Cancer Centre, Bern, Switzerland
Reviewer
- Claudia Bollig, Cochrane Germany Foundation and Institute for Evidence in Medicine, Freiburg, Germany
IQWiG coordinated the project and conducted the literature search for the domains “Benefit assessment“ and “Health economic evaluation”.
According to §139b (3) No. 2 of Social Code Book (SGB) V, Statutory Health Insurance, external experts who are involved in the Institute’s research commissions must disclose “all connections to interest groups and contract organizations, particularly in the pharmaceutical and medical devices industries, including details on the type and amount of any remuneration received”. The Institute received the completed Form for disclosure of potential conflicts of interest from each external expert. The information provided was reviewed by a Committee of the Institute specifically established to assess conflicts of interests. The information on conflicts of interest provided by the external experts and external reviewers is presented in Chapter A11 of the full report. No conflicts of interest were detected that could endanger professional independence with regard to the work on the present commission.
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Translation of Chapters 1 to 9 of the HTA report HT19-01 Fortgeschrittenes Lymphödem: Lassen sich durch nicht medikamentöse Verfahren die Symptome lindern? (Version 1.0; Status: 25 April 2022 [German original], 12 August 2022 [English translation]). Please note: This document was translated by an external translator and is provided as a service by IQWiG to English-language readers.
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