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Some Industrial Chemicals
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 77
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.
This volume of the IARC Monographs evaluates or re-evaluates the carcinogenic risks to humans posed by exposure to sixteen organic industrial chemicals.
These included some aromatic amines (ortho-toluidine, 4-chloro-ortho-toluidine, and 5-chloro-ortho-toluidine), some ethanolamines (di- and triethanolamine and N-nitrosodiethanolamine), and three esters [di(2-ethylhexyl) phthalate (DEHP), di(2-ethylhexyl) adipate, and cinnamyl anthranilate]. Seven of the sixteen compounds were evaluated in previous IARC Monographs and are reconsidered here in the light of new evidence.
Three chemicals were classified or reclassified as probably carcinogenic to humans: ortho-toluidine, 4-chloro-ortho-toluidine, and glycidol. Four compounds, evaluated here for the first time, namely 2,2-bis(bromomethyl)propane-1,3-diol, 2,3-dibromopropan-1-ol, ethylbenzene, and nitromethane, were classified as possibly carcinogenic to humans. N-Nitrosodiethanolamine, which can readily be formed from either di- or triethanolamine in the presence of inorganic nitrite, remained classified as possibly carcinogenic to humans. For eight compounds, including 5-chloro-ortho-toluidine, coumarin, pyridine, diethanolamine, triethanolamine, di(2-ethylhexyl) adipate, and cinnamyl anthranilate, evidence was judged inadequate to classify these compounds according to their carcinogenicity in humans.
The most extensive monograph is devoted to an evaluation of di(2-ethylhexyl) phthalate (DEHP), which had previously been classified as possibly carcinogenic to humans. Using assessment criteria recently established for compounds that induce peroxisome proliferation in the liver, the evaluation downgraded DEHP to the group of compounds that cannot be classified. Two other compounds that cause peroxisome proliferation, di(2-ethylhexyl) adipate and cinnamyl anthranilate, were also evaluated as not classifiable as to carcinogenicity to humans.
Contents
- NOTE TO THE READER
- LIST OF PARTICIPANTS
- PREAMBLE
- GENERAL REMARKS ON THE SUBSTANCES CONSIDERED
- THE MONOGRAPHS
- SUMMARY OF FINAL EVALUATIONS
Corrigenda to the IARC Monographs are published online at: http://monographs.iarc.fr/ENG/Publications/corrigenda.php
LIBRARY CATALOGUING DATA
This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 15–22 February 2000
Lyon, France - 2000
IARC MONOGRAPHS
In 1969, the International Agency for Research on Cancer (IARC) initiated a programme on the evaluation of the carcinogenic risk of chemicals to humans involving the production of critically evaluated monographs on individual chemicals. The programme was subsequently expanded to include evaluations of carcinogenic risks associated with exposures to complex mixtures, life-style factors and biological and physical agents, as well as those in specific occupations.
The objective of the programme is to elaborate and publish in the form of monographs critical reviews of data on carcinogenicity for agents to which humans are known to be exposed and on specific exposure situations; to evaluate these data in terms of human risk with the help of international working groups of experts in chemical carcinogenesis and related fields; and to indicate where additional research efforts are needed.
The lists of IARC evaluations are regularly updated and are available on Internet: http://www.iarc.fr/, under Publications.
This project was supported by Cooperative Agreement 5 UO1 CA33193 awarded by the United States National Cancer Institute, Department of Health and Human Services. Additional support has been provided since 1986 by the European Commission, since 1993 by the United States National Institute of Environmental Health Sciences and since 1995 by the United States Environmental Protection Agency through Cooperative Agreement Assistance CR 824264.
- ©International Agency for Research on Cancer, 2000
- Distributed by IARCPress (Fax: +33 4 72 73 83 02; E-mail: rf.crai@sserp) and by the World Health Organization Distribution and Sales, CH-1211 Geneva 27 (Fax: +41 22 791 4857; E-mail: tni.ohw)@snoitacilbup)
- Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention.
- All rights reserved. Application for rights of reproduction or translation, in part or in toto, should be made to the International Agency for Research on Cancer.
IARC Library Cataloguing in Publication Data
Some industrial chemicals /
- IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2000 : Lyon, France)
- (IARC monographs on the evaluation of carcinogenic risks to humans ; 77)
- 1. Carcinogens – congresses 2. Occupational Exposure – congresses I. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans II. Series
- ISBN 92 832 1277 0 (NLM Classification: W1)
- ISSN 1017-1606
- PRINTED IN FRANCE
- NLM CatalogRelated NLM Catalog Entries
- The traceability of carcinogenic occupational risks: state of progress in France compared with other European countries.[Med Law. 2010]The traceability of carcinogenic occupational risks: state of progress in France compared with other European countries.Fantoni-Quinton S, Frimat P. Med Law. 2010 Dec; 29(4):467-86.
- Dry cleaning, some solvents used in dry cleaning and other industrial chemicals. IARC meeting, Lyon, 7-14 February 1995.[Scand J Work Environ Health. 1...]Dry cleaning, some solvents used in dry cleaning and other industrial chemicals. IARC meeting, Lyon, 7-14 February 1995.McGregor DB, Heseltine E, Møller H. Scand J Work Environ Health. 1995 Aug; 21(4):310-2.
- Occupational exposures to mists and vapours from strong inorganic acids and other industrial chemicals. Working Group views and expert opinions, Lyon, 15-22 October 1991.[IARC Monogr Eval Carcinog Risk...]Occupational exposures to mists and vapours from strong inorganic acids and other industrial chemicals. Working Group views and expert opinions, Lyon, 15-22 October 1991.. IARC Monogr Eval Carcinog Risks Hum. 1992; 54:1-310.
- Review [Assessment of carcinogenic activity of industrial toxicants in occupational epidemiological surveys].[Vestn Ross Akad Med Nauk. 2009]Review [Assessment of carcinogenic activity of industrial toxicants in occupational epidemiological surveys].Il'icheva SA, Zaridze DG. Vestn Ross Akad Med Nauk. 2009; (6):16-9.
- Review [Recent progress in the evaluation of the dangers of chemical carcinogens].[J Pharm Belg. 1990]Review [Recent progress in the evaluation of the dangers of chemical carcinogens].Truhaut R. J Pharm Belg. 1990 Mar-Apr; 45(2):131-40.
- Some Industrial ChemicalsSome Industrial Chemicals
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