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IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide. Lyon (FR): International Agency for Research on Cancer; 1999. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 71.)
| Agent | Degree of evidence of carcinogenicity | Overall evaluation of carcinogenicity to humans | |
|---|---|---|---|
| Human | Animal | ||
| Acetaldehyde | I | S | 2B |
| Acetamide | ND | S | 2B |
| Acrylic acid | ND | ND | 3 |
| Acrylonitrile | I | S | 2B |
| Allyl chloride | I | I | 3 |
| Allyl isovalerate | ND | L | 3 |
| Aziridine | ND | L | 2B* |
| 1,4-Benzoquinone (para-quinone) | ND | I | 3 |
| 1,4-Benzoquinone dioxime | ND | L | 3 |
| Benzoyl peroxide | I | L | 3 |
| Benzyl acetate | ND | L | 3 |
| Bis(2-chloroethyl)ether | I | L | 3 |
| 1,2-Bis(chloromethoxy)ethane | ND | L | 3 |
| 1,4-Bis(chloromethoxymethyl)benzene | ND | L | 3 |
| Bis(2-chloro-1-methylethyl)ether | ND | L | 3 |
| Bis(2,3-epoxycyclopentyl)ether | ND | L | 3 |
| Bisphenol A diglycidyl ether | ND | L | 3 |
| Bromochloroacetonitrile | ND | I | 3 |
| Bromodichloromethane | ND | S | 2B |
| Bromoethane | ND | L | 3 |
| Bromoform | ND | L | 3 |
| 1,3-Butadiene | L | S | 2A |
| 1,2:3,4-Diepoxybutane | S | ||
| n-Butyl acrylate | ND | I | 3 |
| β-Butyrolactone | ND | S | 2B |
| γ-Butyrolactone | I | ESL | 3 |
| Caprolactam | ND | ESL | 4 |
| Carbazole | ND | L | 3 |
| Carbon tetrachloride | I | S | 2B |
| Catechol | ND | S | 2B |
| α-Chlorinated toluenes and benzoyl chloride (combined exposures) | L | 2A | |
| Benzal chloride | L | ||
| Benzotrichloride | S | ||
| Benzyl chloride | S | ||
| Benzoyl chloride | I | ||
| Chloroacetonitrile | ND | I | 3 |
| Chlorodibromomethane | ND | L | 3 |
| Chlorodifluoromethane | I | L | 3 |
| Chloroethane | ND | L | 3 |
| Chlorofluoromethane | ND | L | 3 |
| Chloroprene | I | S | 2B |
| 2-Chloro-1,1,1-trifluoroethane | ND | L | 3 |
| Cyclohexanone | ND | I | 3 |
| Decabromodiphenyl oxide | ND | L | 3 |
| Dibromoacetonitrile | ND | I | 3 |
| 1,2-Dibromo-3-chloropropane | I | S | 2B |
| Dichloroacetonitrile | ND | I | 3 |
| Dichloroacetylene | ND | L | 3 |
| trans-1,4-Dichlorobutene | ND | I | 3 |
| 1,2-Dichloroethane | I | S | 2B |
| Dichloromethane | I | S | 2B |
| 1,2-Dichloropropane | ND | L | 3 |
| 1,3-Dichloropropene (technical-grade) | ND | S | 2B |
| 1,2-Diethylhydrazine | ND | S | 2B |
| Diethyl sulfate | I | S | 2A* |
| Diglycidyl resorcinol ether (technical-grade) | ND | S | 2B |
| Diisopropyl sulfate | I | S | 2B |
| Dimethylcarbamoyl chloride | I | S | 2A* |
| Dimethylformamide | I | ESL | 3 |
| 1,1-Dimethylhydrazine | ND | S | 2B |
| 1,2-Dimethylhydrazine | ND | S | 2A* |
| Dimethyl hydrogen phosphite | ND | L | 3 |
| Dimethyl sulfate | I | S | 2A* |
| 1,4-Dioxane | I | S | 2B |
| Epichlorohydrin | I | S | 2A* |
| 1,2-Epoxybutane | ND | L | 2B* |
| 3,4-Epoxy-6-methylcyclohexylmethyl 3,4-epoxy-6-methylcyclohexane carboxylate | ND | L | 3 |
| cis-9,10-Epoxystearic acid | ND | I | 3 |
| Ethyl acrylate | ND | S | 2B |
| Ethylene dibromide (1,2-dibromoethane) | I | S | 2A* |
| Glycidaldehyde | ND | S | 2B |
| Hexamethylphosphoramide | ND | S | 2B |
| Hydrazine | I | S | 2B |
| Hydrogen peroxide | I | L | 3 |
| Hydroquinone | I | L | 3 |
| Isoprene | ND | S | 2B |
| Isopropanol | I | I | 3 |
| Isopropyl oils | I | I | 3 |
| Lauroyl peroxide | ND | I | 3 |
| Malonaldehyde (malondialdehyde) | ND | L | 3 |
| Methyl acrylate | ND | I | 3 |
| 2-Methylaziridine (propyleneimine) | ND | S | 2B |
| Methyl bromide | I | L | 3 |
| Methyl chloride | I | I | 3 |
| 4,4′-Methylenediphenyl diisocyanate (industrial preparation) | I | 3 | |
| Polymeric 4,4′-methylenediphenyl diisocyanate | I | ||
| Mixture containing monomeric and | L | ||
| polymeric 4,4′-methylenediphenyl diisocyanate | |||
| Methyl iodide | ND | L | 3 |
| Methyl methanesulfonate | ND | S | 2A* |
| Morpholine | ND | I | 3 |
| 1,5-Naphthalene diisocyanate | ND | ND | 3 |
| 2-Nitropropane | I | S | 2B |
| Pentachloroethane | ND | L | 3 |
| Phenol | I | I | 3 |
| Phenyl glycidyl ether | ND | S | 2B |
| Polychlorophenols or their sodium salts (combined exposures) | L | 2B | |
| 2,4-Dichlorophenol | ESL | ||
| 2,4,5-Trichlorophenol | I | ||
| 2,4,6-Trichlorophenol | L | ||
| Pentachlorophenol | S | ||
| Polyvinyl pyrrolidone | ND | L | 3 |
| 1,3-Propane sultone | ND | S | 2B |
| β-Propiolactone | ND | S | 2B |
| Resorcinol | ND | I | 3 |
| 1,1,1,2-Tetrachloroethane | ND | L | 3 |
| 1,1,2,2-Tetrachloroethane | I | L | 3 |
| Tetrafluoroethylene | ND | S | 2B |
| Tetrakis(hydroxymethyl)phosphonium salts | ND | I | 3 |
| Toluene | I | ESL | 3 |
| Toluene diisocyanates | I | S | 2B |
| Trichloroacetonitrile | ND | I | 3 |
| 1,1,1-Trichloroethane | I | I | 3 |
| 1,1,2-Trichloroethane | ND | L | 3 |
| Triethylene glycol diglycidyl ether | ND | I | 3 |
| Tris(2-chloroethyl) phosphate | ND | L | 3 |
| 1,2,3-Tris(chloromethoxy)propane | ND | L | 3 |
| Tris(2,3-dibromopropyl) phosphate | I | S | 2A* |
| Vinyl bromide | ND | S | 2A* |
| Vinylidene chloride | I | L | 3 |
| Vinylidene fluoride | ND | I | 3 |
| N-Vinyl-2-pyrrolidone | ND | L | 3 |
| Xylenes | I | I | 3 |
- *
Other relevant data were taken into account when making the overall evaluation.
ESL, evidence suggesting lack of carcinogenicity; ND, no epidemiological (or animal) data relevant to the carcinogenicity of the compounds were available; I, inadequate evidence of carcinogenicity; L, limited evidence of carcinogenicity; S, sufficient evidence of carcinogenicity; 2A, probably carcinogenic to humans; 2B, possibly carcinogenic to humans; 3, cannot be classified as to its carcinogenicity to humans; 4, probably not carcinogenic to humans
- SUMMARY OF FINAL EVALUATIONS - Re-evaluation of Some Organic Chemicals, Hydrazin...SUMMARY OF FINAL EVALUATIONS - Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide
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