1. Exposure Data

1.1. Chemical and physical data

1.1.1. Nomenclature

• Chem. Abst. Serv. Reg. No.: 2443-39-2
• Systematic name: cis-3-Octyl-oxiraneoctanoic acid

1.1.2. Structural and molecular formulae and relative molecular mass

1.1.3. Physical properties (for details, see IARC, 1976)

• (a) Melting-point: 59.5–59.8°C
• (b) Conversion factor: mg/m³ = 12.29 × ppm

2. Studies of Cancer in Humans

No data were available to the working group.

3. Studies of Cancer in Experimental Animals

cis-9,10-Epoxystearic acid was tested for carcinogenicity in mice by skin application and subcutaneous injection, and in rats by subcutaneous injection. No significant increase in the incidence of tumours was associated with treatment (IARC, 1976).

4. Other Data Relevant to an Evaluation of Carcinogenicity and its Mechanisms

4.4. Genetic and related effects

4.4.1. Humans

No data were available to the Working Group.

4.4.2. Experimental data (see Table 1 for references)

Table 1

Genetic and related effects of cis-9,10-epoxystearic acid.

cis-9,10-Epoxystearic acid was not mutagenic in Salmonella typhimurium in the presence or in the absence of exogenous metabolic activation.

5. Evaluation

No epidemiological data relevant to the carcinogenicity of cis-9,10-epoxystearic acid were available.

There is inadequate evidence in experimental animals for the carcinogenicity of cis-9,10-epoxystearic acid.

6. References

• Chu I., Villeneuve D.C., Nestmann E.R., Douglas G., Becking G.C., Lough R., Matula T.I. Subacute toxicity and mutagenicity of cis-9,10-epoxystearic acid. Bull. environ. Contam. Toxicol. 1980;25:400–403. [PubMed: 7426789]
• IARC (1976) IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man, Vol. 11, Cadmium, Nickel, Some Epoxides, Miscellaneous Industrial Chemicals and General Considerations on Volatile Anaesthetics, Lyon, pp. 153–156. [PubMed: 992654]
• IARC (1987) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Supplement 7, Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, Lyon, p. 63. [PubMed: 3482203]
• Laniado-Schwartzman M., Davis K.L., McGiff J.C., Levere R.D., Abraham N.G. Purification and characterization of cytochrome P-450-dependent arachidonic acid epoxygenase from human liver. J. biol. Chem. 1988;263:2536–2542. [PubMed: 3123495]
• Ulsaker G.A., Teien G. Identification of 9,10-epoxyoctadecanoic acid in human urine using gas chromatography-mass spectrometry. Biomed. Chromatogr. 1995;9:183–187. [PubMed: 8520208]