1. Exposure Data

1.1. Chemical and physical data

1.1.1. Nomenclature

• Chem. Abst. Serv. Reg. No.: 141-37-7
• Systematic name: 4-Methyl-7-oxabicyclo[4.1.0]heptane-3-carboxylic acid, 4-methyl-7-oxabicyclo[4.1.0]hept-3-yl methyl ester

1.1.2. Structural and molecular formulae and relative molecular mass

1.1.3. Physical properties (for details, see IARC, 1976)

• (a) Boiling-point: 215°C at 665 Pa
• (b) Conversion factor: mg/m³ = 11.47 × ppm

2. Studies of Cancer in Humans

No data were available to the Working Group.

3. Studies of Cancer in Experimental Animals

3,4-Epoxy-6-methylcyclohexylmethyl 3,4-epoxy-6-methylcyclohexane carboxylate was tested for carcinogenicity in mice by skin application: it produced skin carcinomas (IARC, 1976).

4. Other Data Relevant to an Evaluation of Carcinogenicity and its Mechanisms

No data were available to the Working Group.

5. Evaluation

No epidemiological data relevant to the carcinogenicity of 3,4-epoxy-6-methylcyclohexylmethyl 3,4-epoxy-6-methylcyclohexane carboxylate were available.

There is limited evidence in experimental animals for the carcinogenicity of 3,4-epoxy-6-methylcyclohexylmethyl 3,4-epoxy-6-methylcyclohexane carboxylate.

6. References

• IARC (1976) IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man, Vol. 11, Cadmium, Nickel, Some Epoxides, Miscellaneous Industrial Chemicals and General Considerations on Volatile Anaesthetics, Lyon, pp. 147–151 [PubMed: 992654]
• IARC (1987) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Supplement 7, Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, Lyon, p. 63 [PubMed: 3482203]